Niigata University of Pharmacy and Applied Life Sciences 1 article published in JoVE Medicine TRUE Gene Silencing: Screening of a Heptamer-type Small Guide RNA Library for Potential Cancer Therapeutic Agents Arisa Haino*1, Tatsuya Ishikawa*1, Mineaki Seki1, Masayuki Nashimoto1 1Research Institute for Healthy Living, Niigata University of Pharmacy and Applied Life Sciences Here we present a protocol for screening of a heptamer-type sgRNA library for potential therapeutic drugs against blood cancers.