Seoul National University College of Medicine, Seoul National University Bundang Hospital 3 articles published in JoVE Bioengineering Isokinetic Robotic Device to Improve Test-Retest and Inter-Rater Reliability for Stretch Reflex Measurements in Stroke Patients with Spasticity Minki Sin*1, Won-Seok Kim*2, Kyujin Cho3, Nam-Jong Paik2 1Department of Medical Assistant Robot, Daegu Research Center, Korea Institute of Machinery & Materials, 2Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 3School of Mechanical and Aerospace Engineering, Seoul National University/IAMD Using a robotic isokinetic device with electromyography (EMG) measurements, this protocol illustrates that isokinetic motion itself can improve inter-rater reliability for the angle of catch measurements in stroke patients with mild elbow flexor spasticity. Behavior Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain Jaewon Beom1,2, Jung Chan Lee2,3,4, Jin Chul Paeng5, Tai Ryoon Han6, Moon Suk Bang7, Byung-Mo Oh7 1Department of Rehabilitation Medicine, Chungnam National University Hospital, Daejeon, 2Department of Biomedical Engineering, Seoul National University College of Medicine, 3Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, 4Department of Biomedical Engineering, Seoul National University Hospital, 5Department of Nuclear Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 6Department of Rehabilitation Medicine, Gangwon Do Rehabilitation Hospital, 7Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul National University College of Medicine We applied repetitive transcranial magnetic stimulation (rTMS) to the unilateral hemisphere of rat brain, by placing a 25-mm figure-8 coil 1 cm lateral to the vertex on the biauricular line and angulating the coil by 45°. An in-house water cooling system was used for rTMS for more than 20 min. Behavior Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia Woo-Jin Kim1, Soo Jung Hahn2, Won-Seok Kim2, Nam-Jong Paik2 1Department of Rehabilitation Medicine, Inje University of Medicine, Haeundae Paik Hospital, 2Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital This study is designed to test the hypothesis that neuronavigational system-guided transcranial magnetic stimulation has higher accuracy for targeting the intended target as demonstrated by eliciting a greater degree of virtual aphasia in healthy subjects, measured by delay in reaction time to picture naming.