Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Puncak Alam 1 article published in JoVE Neuroscience Locomotor Assessment of 6-Hydroxydopamine-induced Adult Zebrafish-based Parkinson's Disease Model Naemah Md Hamzah1, Siong Meng Lim1, Yuganthini Vijayanathan1,2, Fei Tieng Lim1, Abu Bakar Abdul Majeed1, Maw Pin Tan2, Kalavathy Ramasamy1 1Collaborative Drug Discovery Research (CDDR) Group and Brain Degeneration and Therapeutics Group, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Puncak Alam, 2Department of Medicine, Faculty of Medicine, Universiti Malaya The present protocol describes the intracerebroventricular (ICV) injection of adult zebrafish with neurotoxic 6-hydroxydopamine (6-OHDA) at the ventral diencephalon (Dn) and the assessment of the impairment and subsequent recovery of swimming behavior postlesion by using the open tank test, which is accompanied by analysis using a video tracking software.
