HiQScreen Sarl 6 1 article published in JoVE Neuroscience Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission Frédéric Knoflach1, Maria-Clemencia Hernandez1, Daniel Bertrand2 1Discovery Neuroscience, Pharma Research and Early Development, Roche Innovation Center Basel, 2HiQScreen Sàrl 6 Here, we present protocols to discover compounds active at GABAA receptors, from the binding to the physiology and pharmacology.