University Heart Center Hamburg View Institution's Website 6 articles published in JoVE Medicine A Cryoinjury Model to Study Myocardial Infarction in the Mouse Dong Wang*1,2, Grigol Tediashvili*1,2, Xiaomeng Hu1,2, Alessia Gravina2, Sivan G. Marcus1,2, Hao Zhang4, Jeffrey E Olgin4, Tobias Deuse1,2,5, Sonja Schrepfer1,2,3,5 1Transplant and Stem Cell Immunobiology Lab, University Heart Center, 2Department of Surgery, Transplant and Stem Cell Immunobiology Lab, University of California San Francisco, 3Cardiovascular Research Center (CVRC) and DZHK German Center for Cardiovascular Research, 4Division of Cardiology, Cardiovascular Research Institute, University of California San Francisco, 5Cardiovascular Surgery, University Heart Center This article demonstrates a model to study cardiac remodeling after myocardial cryoinjury in mice. Medicine Implantation of hiPSC-derived Cardiac-muscle Patches after Myocardial Injury in a Guinea Pig Model Liesa Castro1,2, Birgit Geertz3, Marina Reinsch2,3, Bülent Aksehirlioglu3, Arne Hansen2,3, Thomas Eschenhagen2,3, Hermann Reichenspurner1,2, Florian Weinberger*2,3, Simon Pecha*1,2 1Department of Cardiovascular Surgery, University Heart Center Hamburg, 2partner site Hamburg/Kiel/Lübeck, German Centre for Cardiovascular Research (DZHK), 3Department of Experimental Pharmacology and Toxicology, Cardiovascular ResearchCenter, University Medical Center Hamburg-Eppendorf Here we present a protocol for the induction of left ventricular cryoinjury followed by the implantation of a cardiac muscle patch, derived from human iPS-cell cardiomyocytes in a guinea pig model. Medicine Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta Grigol Tediashvili1,2,3, Dong Wang1,2,3,4, Hermann Reichenspurner4, Tobias Deuse1,2,3,4, Sonja Schrepfer1,2,3,4 1Transplant and Stem Cell Immunobiology Lab, University Heart Center, 2Department of Surgery, Transplant and Stem Cell Immunobiology Lab, University of California San Francisco (UCSF), 3Cardiovascular Research Center (CVRC) and DZHK German Center for Cardiovascular Research, 4Cardiovascular Surgery, University Heart Center This article demonstrates a murine model to study the development of myointimal hyperplasia (MH) after aortic balloon injury. Medicine Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency Dong Wang1,2,3,4, Grigol Tediashvili1,2,3, Simon Pecha4, Hermann Reichenspurner4, Tobias Deuse1,2,3,4, Sonja Schrepfer1,2,3,4 1Transplant and Stem Cell Immunobiology Lab, University Heart Center Hamburg, 2Department of Surgery, Transplant and Stem Cell Immunobiology Lab, University of California San Francisco (UCSF), 3Cardiovascular Research Center (CVRC) and DZHK German Center for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck, 4Cardiovascular Surgery, University Heart Center Hamburg This video demonstrates a model to study the development of myointimal hyperplasia after venous interposition surgery in rats. Medicine Inducing Myointimal Hyperplasia Versus Atherosclerosis in Mice: An Introduction of Two Valid Models Mandy Stubbendorff*1,2, Xiaoqin Hua*1,2, Tobias Deuse1,2,3, Ziad Ali4,5, Hermann Reichenspurner2,3, Lars Maegdefessel6, Robert C. Robbins7, Sonja Schrepfer1,2,3,4 1Transplant and Stem Cell Immunobiology Lab, Cardiovascular Research Center, University Hospital Hamburg, 2Cardiovascular Research Center (CVRC) and DZHK University Hamburg, 3Department of Cardiovascular Surgery, University Heart Center Hamburg, 4Center for Interventional Vascular Therapy, Division of Cardiology, Columbia University, 5Cardiovascular Research Foundation, New York, 6Karolinska Institute, Stockholm, 7Department of Cardiothoracic Surgery, Stanford University School of Medicine, Falk Cardiovascular Research Center This video shows two models of intimal plaque development in murine arteries and emphasizes the differences in myointimal hyperplasia and atherosclerosis. Medicine Human Internal Mammary Artery (IMA) Transplantation and Stenting: A Human Model to Study the Development of In-Stent Restenosis Xiaoqin Hua1,2, Tobias Deuse1,2, Evangelos D. Michelakis3, Alois Haromy3, Phil S. Tsao4, Lars Maegdefessel4, Reinhold G. Erben5, Claudia Bergow5, Boris B. Behnisch6, Hermann Reichenspurner1,2, Robert C. Robbins7, Sonja Schrepfer1,2,7 1University Heart Center Hamburg, TSI-Lab, Germany, 2Cardiovascular Research Center, University of Hamburg, 3Department of Medicine, Cardiology Division, Pulmonary Hypertension Program, University of Alberta, 4Department of Medicine, Stanford University School of Medicine, 5Department of Biomedical Sciences, Institute of Physiology, Pathophysiology, and Biophysics, University of Veterinary Medicine, Vienna, 6Translumina GmbH, Hechingen, 7Department of Cardiothoracic Surgery, Stanford University School of Medicine This video shows a model to study the development of intimal hyperplasia after stent deployment using a human vessel (IMA) in an immunodeficient rat model.