Cluster of Excellence CellNetworks

1 article published in JoVE

• Bioengineering

  
  Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus (AAV) Capsid Variants Kleopatra Rapti^1,2, Olena Maiakovska^1,2, Jonas Becker^1,2, Joanna Szumska^1,2, Margarita Zayas^1,2, Felix Bubeck^1,2, Jixin Liu^1,2, Emma Gerstmann^1,2, Chiara Krämer^1,2, Ellen Wiedtke^1,2, Dirk Grimm^{1,2,3,4,5 1}Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, University of Heidelberg, ²BioQuant Center, BQ0030, University of Heidelberg, ³Cluster of Excellence CellNetworks, ⁴German Center for Infection Research (DZIF), ⁵German Center for Cardiovascular Research (DZHK) AAV peptide display library generation and subsequent validation through the barcoding of candidates with novel properties for the creation of next-generation AAVs.