CHU Clermont-Ferrand 1 article published in JoVE Medicine Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device Raiko Blondonnet1,2, Bertille Paquette1,2, Jules Audard1,2, Ridvan Guler1,2, François-Xavier Roman1,2, Ruoyang Zhai2, Corinne Belville2, Loïc Blanchon2, Thomas Godet1, Emmanuel Futier1,2, Jean-Etienne Bazin1, Jean-Michel Constantin3, Vincent Sapin2,4, Matthieu Jabaudon1,2,5 1Department of Perioperative Medicine, CHU Clermont-Ferrand, 2GReD, CNRS, INSERM, Université Clermont Auvergne, 3GRC 29, AP-HP, DMU DREAM, Department of Anesthesiology and Critical Care, Pitié-Salpêtrière Hospital, Sorbonne University, 4Department of Biochemistry and Molecular Genetics, CHU Clermont-Ferrand, 5Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center We describe a model of hydrochloric acid-induced acute respiratory distress syndrome (ARDS) in piglets receiving sedation with halogenated agents, isoflurane and sevoflurane, through a device used for inhaled intensive care sedation. This model can be used to investigate the biological mechanisms of halogenated agents on lung injury and repair.
