Aix-Marseille Universite 1 article published in JoVE Cancer Research Flexible Organic Electronic Devices for Pulsed Electric Field Therapy of Glioblastoma Marie C. Lefevre1, Attila Kaszas1, Gerwin Dijk1,2, Martin Baca1, Olivier Baudino2, Bastien Marchiori2, Loig Kergoat2, David Moreau1, Franck Debarbieux3,4,5, Rodney P. O'Connor1 1Centre CMP, Bioelectronics Department, Mines Saint-Etienne, 2Panaxium SAS, 3Institut Universitaire de France, 4Institut des Neurosciences de la Timone (UMR7289), CNRS, Aix-Marseille Université, 5Centre Européen de Recherche en Imagerie Médicale, Aix-Marseille Université This work describes the development of flexible interdigitated electrodes for implementation in 3D brain tumor models, namely, in vitro culture, in ovo model, and in vivo murine model. The proposed method can be used to evaluate the effects of pulsed electric fields on tumors at different levels of complexity.
