Lancaster University 1 article published in JoVE Biology High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health Irtiqa Ali*1, Jack Martin*1, Alejandra Zárate-Potes1, Alexandre Benedetto1 1Division of Biomedical and Life Sciences, Lancaster University Gut microbes may positively or negatively impact the health of their host via specific or conserved mechanisms. Caenorhabditis elegans is a convenient platform to screen for such microbes. The present protocol describes high-throughput screening of 48 bacterial isolates for impact on nematode stress resistance, used as a proxy for worm health.