Engelhardt Institute of Molecular Biology 1 article published in JoVE Medicine Murine Model of Intestinal Ischemia-reperfusion Injury Ekaterina O. Gubernatorova1,2, Ernesto Perez-Chanona3, Ekaterina P. Koroleva1, Christian Jobin3, Alexei V. Tumanov1,2 1Trudeau Institute, 2Engelhardt Institute of Molecular Biology, 3Departments of Medicine and Infectious Diseases and Pathology, University of Florida Here we describe the detailed procedure of intestinal ischemia-reperfusion in mice which results in reproducible injury without mortality to encourage the standardization of this technique across the field. This model of intestinal ischemia-reperfusion injury can be utilized to study the cellular and molecular mechanisms of injury and regeneration.
