Oncomedic 1 article published in JoVE Biology CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion Orlando Santillán1, Miguel A. Ramírez-Romero2, Guillermo Dávila3 1Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, 2Oncomedic Incorporation, Ciudad de México, 3Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México Here, we present chimera assembly by plasmid recovery and restriction enzyme site insertion (CAPRRESI), a protocol based on the insertion of restriction enzyme sites into synonym DNA sequences and functional plasmid recovery. This protocol is a fast and low-cost method for fusing protein-coding genes.