Applied Medical 1 article published in JoVE Medicine Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats John R. Wagner1, Takashi Taguchi1, Jane Y. Cho2, Chandrashekhar Charavaryamath3, Dominique J. Griffon1 1College of Veterinary Medicine, Western University of Health Sciences, 2Applied Medical, 3College of Veterinary Medicine, Iowa State University This paper describes the preparation and evaluation of umbilical cord matrix-derived mesenchymal stem cells spheroids with a bilateral patellar tendon defect model in a rat. This model was associated with an acceptable morbidity and was found to detect differences between untreated and treated tendons, and between the two treatments tested.