Torrey Pines Institute for Molecular Studies 1 article published in JoVE Bioengineering A Novel Three-dimensional Flow Chamber Device to Study Chemokine-directed Extravasation of Cells Circulating under Physiological Flow Conditions Valentina Goncharova1, Sophia K. Khaldoyanidi1,2 1Torrey Pines Institute for Molecular Studies, 2Cascade LifeSciences Inc. The three-dimensional flow chamber device is a novel in vitro technology for the quantitative and step-wise evaluation of the extravasation cascade of cells circulating under conditions of physiological shear stress. The device therefore fills a critical need for basic, preclinical, and clinical studies of cell migration.
