Renz Research, Inc. 1 article published in JoVE Biochemistry On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature Linta M. Biju*1, Cong Wang*1, Weijia Kang1, Irin P. Tom1, Indika Kumarapperuma1, Xiaojing Yang1,2, Zhong Ren1,3 1Department of Chemistry, University of Illinois at Chicago, 2Department of Ophthalmology and Vision Sciences, University of Illinois at Chicago, 3Renz Research, Inc. This contribution describes how to set up protein crystallization on crystal-on-crystal devices and how to perform automated serial data collection at room temperature using the on-chip crystallization platform.