Friedman Brain Institute at Mount Sinai 1 article published in JoVE Neuroscience Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease Camille Goldman*1,2,3,4,5, Natalie Suhy*1,2,3,4,5, Jessica E. Schwarz1,2,3,4,5, Emily Ruth Sartori1,2,3,4,5, Rikki B. Rooklin1,2,3,4,5, Braxton R. Schuldt1,2,3,4,5, Louise A. Mesentier-Louro1,2,3,4,5, Joel W. Blanchard1,2,3,4,5 1Icahn School of Medicine at Mount Sinai, 2Black Family Stem Cell Institute at Mount Sinai, 3Ronald M. Loeb Center for Alzheimer’s Disease at Mount Sinai, 4Friedman Brain Institute at Mount Sinai, 5Nash Family Department of Neuroscience at Mount Sinai The blood-brain barrier (BBB) has a crucial role in sustaining a stable and healthy brain environment. BBB dysfunction is associated with many neurological diseases. We have developed a 3D, stem-cell-derived model of the BBB to investigate cerebrovascular pathology, BBB integrity, and how the BBB is altered by genetics and disease.
