Merck 1 article published in JoVE Biochemistry An Open-Source Framework for Mass Calculation of Antibody-Based Therapeutic Molecules Thomas Harkins1,2, Li Cao1, Kshitij Khatri1,3 1GlaxoSmithKline, 2Merck, 3Moderna This article describes the use of a software application, mAbScale, for the calculation of masses for monoclonal antibody-based protein therapeutics.