University of Colima View Institution's Website 1 article published in JoVE Neuroscience Targeting of Deep Brain Structures with Microinjections for Delivery of Drugs, Viral Vectors, or Cell Transplants Oscar Gonzalez-Perez1, Hugo Guerrero-Cazares2, Alfredo Quiñones-Hinojosa2 1 Neuroscience Lab/ Fac. Psicologia, University of Colima, 2Department of Neurosurgery, Johns Hopkins University In this article, we show a method to make glass capillary needles with a 50-μm lumen. This technique significantly reduces the brain damage, minimizes passive diffusion of drugs and allows a precise targeting into the rodent brain.