Universidade São Judas Tadeu View Institution's Website 1 article published in JoVE Neuroscience Rapid Determination of the Thermal Nociceptive Threshold in Diabetic Rats Saeed Alshahrani1, Filipe Fernandez-Conti2, Amanda Araujo2, Mauricio DiFulvio1 1Department of Pharmacology and Toxicology, Wright State University, 2Human Movement Laboratory, Universidade São Judas Tadeu Here, we describe a rapid reliable and simple procedure to determine the lowest temperature at which rats or mice show nocifensive behavior, i.e. the thermal nociceptive threshold (TNT). This method applies a slowly increasing thermal stimulus allowing precise and reproducible estimation of TNTs with minimum, if any, stress to the animals.
