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Bioengineering

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JoVE Journal Bioengineering
Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing
A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces
Journal (Bioengineering)
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Journal (Bioengineering)
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Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing

Article DOI: 10.3791/50288-v • 11:09 min • March 19th, 2013
March 19th, 2013 •
1, 1,2
1Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, 2Harvard Stem Cell Institute

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Summary
Automatic Translation

The generation of aligned myocardial tissue is a key requirement for adapting the recent advances in stem cell biology to clinically useful purposes. Herein we describe a microcontact printing approach for the precise control of cell shape and function. Using highly purified populations of embryonic stem cell derived cardiac progenitors, we then generate anisotropic functional myocardial tissue.

Tags

Generation Aligned Functional Myocardial Tissue Microcontact Printing Heart Failure Viable Cardiac Muscle Cells Drug Therapy Mortality Morbidity Cellular Assays Human Myocardial Physiology Regenerative Cardiac Biology Patient-specific Cardiac Progenitors Functional Tissue Native Heart Tissue Architecture Micropatterned Protein Shapes Geometric Cues Cell Adhesion Spatially Isolation Of Myocardial Cells Pluripotent Stem Cells Differentiation Cell Growth Surfaces Extracellular Matrix Proteins Stem Cell-derived Cardiac Muscle Cells Anisotropic Myocardial Tissue
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