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Bioluminescent Orthotopic Model of Pancreatic Cancer Progression

Article DOI: 10.3791/50395-v • 09:25 min • June 28th, 2013
June 28th, 2013 •
1, 1,2, 2, 1,3
1Monash Institute of Pharmaceutical Sciences, Monash University, 2Department of Visceral Surgery and Medicine, University of Bern, 3Cousins Center for Neuroimmunology, University of California Los Angeles

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Summary
Automatic Translation

Improved understanding of pancreatic cancer biology is critically needed to enable the development of better therapeutic options to treat pancreatic cancer. To address this need, we demonstrate an orthotopic model of pancreatic cancer that permits non-invasive monitoring of cancer progression using in vivo bioluminescence imaging.

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Bioluminescent Orthotopic Model Pancreatic Cancer Progression Survival Rate Therapeutic Options Pancreatic Cancer Biology Cancer Cells Pancreatic Microenvironment Non-invasive Monitoring Orthotopic Model Luciferase-tagged Cells Matrigel Laparotomy Primary Tumor Growth Metastasis Luciferin Substrate In Vivo Imaging Bioluminescence Emission Primary Tumor Recurrence Resection Syngeneic Models Xenograft Models Pre-clinical Trials Anti-cancer Therapeutics
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