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In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves
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In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves

Article DOI: 10.3791/51181-v • 11:07 min • April 13th, 2014
April 13th, 2014 •
1, 2, 1, 3
1Leibniz Institute for Age Research, Fritz Lipmann Institute, 2Friedrich Schiller University Jena, 3Institute of Molecular Cell Biology & Center for Sepsis Control and Care (CSCC) Jena University Hospital, Friedrich Schiller University Jena

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Summary
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Measurements of nerve conduction properties in vivo exemplify a powerful tool to characterize various animal models of neuromuscular diseases. Here, we present an easy and reliable protocol by which electrophysiological analysis on sciatic nerves of anesthetized mice can be performed.

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In Vivo Electrophysiological Measurements Mouse Sciatic Nerves Electrophysiological Studies Neuromuscular Diseases Pathophysiology Mouse Sciatic Nerves Anesthesia Isoflurane Analgesia Body Temperature Heating Plate Rectal Thermo Probe Electrocardiogram (ECG) Peripheral Nervous System (PNS) Motoric Fiber Tracts Sensory Fiber Tracts Needle Electrodes Nerve Stimulations Transmitted Potentials Data Processing
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