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Electrophysiological Motor Unit Number Estimation (MUNE) Measuring Compound Muscle Action Potential (CMAP) in Mouse Hindlimb Muscles
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Electrophysiological Motor Unit Number Estimation (MUNE) Measuring Compound Muscle Action Potential (CMAP) in Mouse Hindlimb Muscles

Article DOI: 10.3791/52899-v • 09:07 min • September 25th, 2015
September 25th, 2015 •
1,2,3, 1, 4, 1,3, 1,3,4, 1,3,4
1Department of Neurology, The Ohio State University Wexner Medical Center, 2Department of Physical Medicine and Rehabilitation, The Ohio State University, 3Department of Neuroscience, The Ohio State University Wexner Medical Center, 4Department of Biochemistry and Pharmacology, The Ohio State University Wexner Medical Center

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Summary
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We present refined protocols that allow in vivo monitoring of motor unit function in the mouse. Techniques to measure compound muscle action potential (CMAP) and motor unit number estimation (MUNE) in the mouse hind limb muscles innervated by the sciatic nerve are described.

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Electrophysiological Motor Unit Number Estimation (MUNE) Compound Muscle Action Potential (CMAP) Mouse Hindlimb Muscles Functional Status Motor Unit Pool Neuromuscular System Translational Potential Diagnostic Clinical Human Studies Sciatic Nerve Function Supramaximal Stimulation Peripheral Nerve Motor Neurons Axons Muscle Control Input Surface Recording Electrodes Incremental MUNE Technique Single Motor Unit Potential (SMUP) CMAP Amplitude
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