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Journal / Bioengineering / Transport Properties of Ibuprofen Encapsulated in …
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Bioengineering

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JoVE Journal Bioengineering
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Article DOI: 10.3791/53769-v • 10:10 min • August 15th, 2016
August 15th, 2016 •
*1, *1, 1, 1,2, 3, 4, 5, 1
1Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, 2Università degli studi e-Campus, 3ICRM, CNR - Consiglio Nazionale delle Ricerche, 4Elettra Sincrotrone Trieste, 5Department of Chemistry, University of Torino
* These authors contributed equally

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Summary
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The motion regimes of ibuprofen encapsulated in β-cyclodextrin nanosponges polymer network are investigated using pulsed-field-gradient spin-echo (PGSE) NMR technique. Synthesis, purification, drug loading, implementation of the NMR pulse sequence and data analysis to work out the mean square displacement of the drug at several observation times are described in detail.

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Transport Properties Ibuprofen Cyclodextrin Nanosponge Hydrogels Proton HR-MAS NMR Spectroscopy Drug-loaded Hydrogels Diffusivity High-resolution Magic Angle Spinning NMR Spectroscopy Drug Delivery Synthesis Step-growth Polymerization CDs EDTA DNA Dried Network Of CD Units Formic CD Units Organic And Inorganic Species Absorption And Release Polymeric Host Drug Trapped In Polymeric Hydrogen Metrics Beta Cyclodextrin DMSO Triethylamine
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