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JoVE Journal Medicine
Murine Left Anterior Descending (LAD) Coronary Artery Ligation
Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter
Journal (Medicine)
Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter
A Tissue Displacement-based Contusive Spinal Cord Injury Model in Mice
Journal (Medicine)
A Tissue Displacement-based Contusive Spinal Cord Injury Model in Mice
 

Murine Left Anterior Descending (LAD) Coronary Artery Ligation: An Improved and Simplified Model for Myocardial Infarction

Article DOI: 10.3791/55353-v • 10:39 min • April 2nd, 2017
April 2nd, 2017 •
*1, *1, 1, 1, 1, 1
1Cardiothoracic Surgery Division, Rhode Island Hospital, Brown University Warren Alpert Medical School
* These authors contributed equally

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Summary
Automatic Translation

We provide a reliable method for left anterior descending artery (LAD) ligation in a mouse model. This method is comparatively less invasive than other methods, involving endotracheal intubation, a left-sided thoracotomy approach, and thoracentesis. This method can be used as a model for both acute and chronic myocardial infarction (MI).

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Murine Left Anterior Descending (LAD) Coronary Artery Ligation Myocardial Infarction Cardiovascular Field Overexpression Knock Out Genes Recovery Of The Heart Invasive Recovery Time Complications Endotracheal Intubation LAD Artery Visual Demonstration Sedating The Animal Bead Sterilizer Sedated Mouse Breathing Rate Styrofoam Board Oropharynx Toe Pinch Elastic Band
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