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Journal / Developmental Biology / Precise Cellular Ablation Approach for Modeling…
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Developmental Biology

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JoVE Journal Developmental Biology
Precise Cellular Ablation Approach for Modeling Acute Kidney Injury in Developing Zebrafish
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Precise Cellular Ablation Approach for Modeling Acute Kidney Injury in Developing Zebrafish

Article DOI: 10.3791/55606-v • 09:53 min • June 3rd, 2017
June 3rd, 2017 •
1, 1, 2, 1, 1, 1
1Department of Biomedical Sciences, NYITCOM, 2Department of Basic Sciences, NYITCOM-A-State

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Summary
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This work presents a new in vivo model of segmental kidney injury using kidney GFP transgenic zebrafish. The model allows for the induction of the targeted ablation of kidney epithelial cells to show the cellular mechanisms of nephron injury and repair.

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Cellular Ablation Acute Kidney Injury Zebrafish Modeling Nephron Injury Kidney Regeneration Spatial Temporal Control Injury Level Adjustment Therapy Diagnosis GFP Fluorescent Zebrafish Live Imaging Low Melting Agarose Trigaine Solution
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