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Journal / Bioengineering / Retroductal Nanoparticle Injection to the Murine…
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Bioengineering

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JoVE Journal Bioengineering
Retroductal Nanoparticle Injection to the Murine Submandibular Gland
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Retroductal Nanoparticle Injection to the Murine Submandibular Gland

Article DOI: 10.3791/57521-v • 07:45 min • May 3rd, 2018
May 3rd, 2018 •
1, 2, 1, 1, 2, 3, 1
1Department of Biomedical Engineering, University of Rochester, 2Department of Otolaryngology Head and Neck Surgery, University of Rochester Medical Center, 3Center for Oral Biology, University of Rochester Medical Center

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Summary
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Local drug delivery to the submandibular glands is of interest in understanding salivary gland biology and for the development of novel therapeutics. We present an updated and detailed retroductal injection protocol, designed to improve delivery accuracy and experimental reproducibility. The application presented herein is the delivery of polymeric nanoparticles.

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Retroductal Nanoparticle Injection Murine Submandibular Gland Direct Delivery Systemic Circulation Bypass Salivary Gland Dysfunction Radiation Treatment Head And Neck Malignancy Locating Submandibular Duct Cannulating Submandibular Duct Sedated Animal Intracranial Catheter Tubing Beveled End Wire Inset PSMA Nanoparticle Solution Hamilton Syringe Burrow Trauma Injection Solution Inspection Ductal Obstruction Prevention Atropine Solution Visualization Prone Position
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