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JoVE Journal Cancer Research
Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Article DOI: 10.3791/58291-v • 15:04 min • January 19th, 2019
January 19th, 2019 •
*1, *1, *1,2, *1, *1,3, *1,3
1Centre de Recherche en Cancérologie et Immunologie Nantes Angers (CRCINA), Institut national de la santé et de la recherche médicale (INSERM), Université d'Angers, Université de Nantes, Nantes, France, 2Service de chirurgie pédiatrique, Centre hospitalier universitaire (CHU) de Nantes, Nantes, France, 3Unité de Formation et Recherche (UFR) des Sciences Pharmaceutiques et Biologiques, Université de Nantes, Nantes, France
* These authors contributed equally

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Summary
Automatic Translation

This protocol describes how to assess synergism between an anticancer antibody and antineoplastic drugs in preclinical models by using the combination index equation of Chou and Talalay.

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Potentiation Anticancer Antibody Antineoplastic Drugs Antibody-drug Synergism Combination Index Equation Immunotherapy Chemotherapy Therapeutic Effects Dose Reduction Toxicity Reduction Drug Resistance Clinical Trials Preclinical Combination Studies In Vitro In Animals Quantification Of Synergism Monoclonal Antibody 8B6 O-Acetyl-GD2 Ganglioside Neuroblastoma Antigen Topotecan Neuroblastoma Cells Effective Dose 50 Values IMO-5 Neuroblastoma Cell Line Combination Index Values Computer Simulation In Vivo Tumor Xenograft Model
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