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Journal / Developmental Biology / 静脉畸形的患者衍生异种移植模型
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Developmental Biology

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静脉畸形的患者衍生异种移植模型
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静脉畸形的患者衍生异种移植模型

Article DOI: 10.3791/61501-v • 06:51 min • June 15th, 2020
June 15th, 2020 •
*1, *1, 1,2
1Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, 2Department of Pediatrics, University of Cincinnati College of Medicine
* These authors contributed equally

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我们提出了一个详细的协议，以生成静脉畸形的杂音异种模型。该模型基于患者衍生的内皮细胞的皮下注射，这些内皮细胞含有超激活的 TIE2 和/或 PIK3CA 基因突变。异种移植病变密切回顾VM患者组织组织组织病理学特征。

Tags

发育生物学， 问题 160， 静脉畸形， 异种移植， 内皮细胞， TIE2， PIK3CA， 血管病变
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