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JoVE Journal Developmental Biology
En pasientavledet Xenograft-modell for venøs misdannelse
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En pasientavledet Xenograft-modell for venøs misdannelse

Article DOI: 10.3791/61501-v • 06:51 min • June 15th, 2020
June 15th, 2020 •
*1, *1, 1,2
1Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, 2Department of Pediatrics, University of Cincinnati College of Medicine
* These authors contributed equally

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Vi presenterer en detaljert protokoll for å generere en murine xenograft modell av venøs misdannelse. Denne modellen er basert på subkutan injeksjon av pasientavledede endotelceller som inneholder hyperaktiverende TIE2- og/eller PIK3CA-genmutasjoner. Xenograft lesjoner nøye rekatolere histopatologiske trekk ved VM pasientvev.

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Utviklingsbiologi Utgave 160 Venøs misdannelse xenograft endotelceller TIE2 PIK3CA vaskulær lesjon
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