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JoVE Journal Biology
En modifisert teknikk for tverrgående aortainnsnevring hos mus
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En modifisert teknikk for tverrgående aortainnsnevring hos mus

Article DOI: 10.3791/64386-v • 04:52 min • August 18th, 2022
August 18th, 2022 •
*1,2, *1,2, *1,2, 1,2
1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 2Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
* These authors contributed equally

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Den foreliggende protokollen beskriver en modifisert og forenklet teknikk med en minimalt invasiv transvers aortakonstriksjon (TAC) prosedyre ved bruk av en selvfremstilt retractor. Denne prosedyren kan utføres uten ventilator eller mikroskop og introduserer trykkoverbelastning, noe som til slutt fører til hjertehypertrofi eller hjertesvikt.

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