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JoVE Journal Neuroscience
Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
 

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

Article DOI: 10.3791/50716-v • 11:45 min • November 14th, 2013
November 14th, 2013 •
1,2, 2, 3, 3, 4, 2,5
1Division of Biology, California Institute of Technology, 2Solomon H. Snyder Department of Neuroscience, Neurology, and Ophthalamology, Johns Hopkins University School of Medicine, 3Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 4Department of Radiation Oncology, University Of Washington Medical Center, 5Institute for Cell Engineering and High-Throughput Biology Center, Johns Hopkins University School of Medicine

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Summary
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The function of adult-born mammalian neurons remains an active area of investigation. Ionizing radiation inhibits the birth of new neurons. Using computer tomography-guided focal irradiation (CFIR), three-dimensional anatomical targeting of specific neural progenitor populations can now be used to assess the functional role of adult neurogenesis.

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Keywords: Adult Neurogenesis Hypothalamus Median Eminence Focal Irradiation Radiological Inhibition Computer Tomography-guided Focal Irradiation (CFIR) Functional Characterization Small Animal Models
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