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Measuring Respiratory Function in Mice Using Unrestrained Whole-body Plethysmography
JoVE Journal
Biology
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JoVE Journal Biology
Measuring Respiratory Function in Mice Using Unrestrained Whole-body Plethysmography
DOI:

08:51 min

August 12, 2014

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Chapters

  • 00:05Title
  • 01:20Initial Setup
  • 02:04Bridge Amplifier Calibration
  • 03:53Recording Lung Function
  • 05:03Plethysmography Analysis
  • 07:14Results: Unrestrained Whole-body Plethysmography (UWBP)
  • 08:07Conclusion

Summary

Automatic Translation

The assessment of respiratory physiology has traditionally relied upon techniques, which require restraint or sedation of the animal. Unrestrained whole-body plethysmography, however, provides precise, non-invasive, quantitative analysis of respiratory physiology in animal models. In addition, the technique allows repeated respiratory assessment of mice allowing for longitudinal studies.

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