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Journal / Bioengineering / The Multi-organ Chip - A Microfluidic Platform…
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Bioengineering

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JoVE Journal Bioengineering
The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
 

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Article DOI: 10.3791/52526-v • 10:05 min • April 28th, 2015
April 28th, 2015 •
*1, *1,2, 1, 1,2, 1, 3, 3, 1, 1,2
1Medical Biotechnology, Technische Universität Berlin, 2TissUse GmbH, 3Fraunhofer IWS
* These authors contributed equally

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Summary
Automatic Translation

Here, we present a protocol to coculture primary cells, tissue models and punch biopsies in a microfluidic multi-organ chip for up to 28 days. Human dermal microvascular endothelial cells, liver aggregates and skin biopsies were successfully combined in a common media circulation.

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Keywords: Multi-organ Chip Microfluidic Platform Long-term Multi-tissue Coculture Drug Testing In Vitro Models Organ-on-a-chip Bioreactor HepaRG Cells Human Hepatic Stellate Cells Human Skin Air-liquid Interface Physiological Fluid Flow Vascularization Microfluidic Channel Repeated Substance Exposure
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