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Surgical Procedures and Methodology for a Preclinical Murine Model of De Novo Mammary Cancer Metastasis
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Chapters
- 00:00Title
- 00:30Introduction
- 01:20Sterilization of Surgical Site
- 02:06Primary Tumor Exposure
- 03:15Removal of Primary Tumor
- 06:06Wound Closure
- 07:35Representative Results
- 07:55Conclusion
Pre-clinical models evaluating adjuvant therapy targeting breast cancer metastasis are lacking. To address this, we developed a murine model of de novo pulmonary mammary adenocarcinoma metastasis, wherein therapies administered in the adjuvant setting (post surgical resection of primary tumors) can be evaluated for efficacy in impacting previously seeded pulmonary metastases.
