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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
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Chapters
- 00:04Title
- 00:46Establishment of Resiniferatoxin (RTX) Neuropathy
- 01:45Behavioral Testing: Hot Plate and von Frey Hair
- 03:55Skin Biopsy Preparation and Evaluation of IENFs Innervation
- 06:18DRG Section Preparation and Evaluation of Injured Small-Diameter Neurons
- 07:25Results: Comparing RTX Doses
- 08:35Conclusion
This study establishes an experimental model of pure small fiber neuropathy with resiniferatoxin (RTX). A unique dose of RTX (50 µg/kg) is optimal for developing a small fiber neuropathy model that mimics patient characteristics and could help investigate the nociceptive molecular significance underlying neuropathic pain.
