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Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
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JoVE Journal Neuroscience
Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

DOI:
10.3791/57570-v

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06:04 min

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September 02, 2020

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, ,
1Laboratory of Clinical Pharmacy and Pharmacology,Musashino University, 2Research Institute of Pharmaceutical Sciences,Musashino University

Chapters

  • 00:05Title
  • 00:36Subcutaneous or Intracerebroventricular Injection of RTX
  • 02:02RTX Test
  • 03:11Tail Pressure Test
  • 04:22Results: Nociceptive Responses of Mice that Were Pretreated Subcutaneously or Intracerebroventricularly with RTX
  • 05:37Conclusion

Summary

Automatic Translation

Automatic Translation

The transient receptor potential vanilloid type 1 (TRPV1) in the supraspinal region has been suggested to play some roles in the brain function. Described here is a protocol for intracerebroventricular injection of resiniferatoxin for supraspinal TRPV1 desensitization in mice. Procedures for some pain tests are also presented.

Tags

IntracerebroventricularResiniferatoxinTRPV1 DesensitizationAnesthesiaSubcutaneous InjectionPaw WithdrawalTail Pressure TestNociceptionMouse ModelNeuropharmalogical Research

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