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A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
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JoVE Journal Medicine
A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

DOI:
10.3791/62080-v

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06:44 min

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February 28, 2021

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, , , , ,
1Department of Surgery,Medical University of South Carolina, 2Ralph H. Johnson Veterans Affairs Medical Center

Chapters

  • 00:04Introduction
  • 00:52Mouse Monitoring and Surgery
  • 04:03Results: Representative Effect of Bile Duct TNBS Infusion in a Mouse Chronic Pancreatitis Model
  • 05:48Conclusion

Summary

Automatic Translation

Automatic Translation

Chronic pancreatitis (CP) is a disease characterized by inflammation and fibrosis of the pancreas, often associated with intractable abdominal pain. This article focuses on refining the technique to generate a mouse model of CP via bile duct infusion with 2,4,6 -trinitrobenzene sulfonic acid (TNBS).

Tags

Mouse ModelChronic PancreatitisBile DuctTNBS InfusionNeuropathic PainVon Frey MonofilamentsTNBS SolutionPancreatic DuctAbdominal PainFibrosisInflammation

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