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Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
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Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation

DOI:
10.3791/63094-v

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08:56 min

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September 24, 2021

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, , , , , , , , , , ,
1Laboratory of Physiopharmacology,University of Antwerp, 2Department of Cardiac Surgery,University Hospital Antwerp, 3Department of Animal Welfare,University of Antwerp, 4Comparative Perinatal Development,University of Antwerp, 5Department of Cardiology,University Hospital Antwerp, 6Department of Cardiology,ZNA Middelheim Hospital, 7Research Group Cardiovascular Diseases, GENCOR,University of Antwerp

Chapters

  • 00:05Introduction
  • 00:57Arterial Line Placement
  • 01:40Surgical Placement of a Permanent Central Venous Catheter
  • 02:33Sternotomy
  • 03:15Pacemaker Lead Placement
  • 04:49Induction of Sterile Pericarditis
  • 05:29Atrial Tachypacing for Induction of AF
  • 06:41Results: Analysis of Evolution of Electrophysiology Parameters Over Time and Comparison of Interstitial/Perivascular Fibrosis in the Sterile Pericarditis Animals and Shams
  • 08:05Conclusion

Summary

Automatic Translation

Automatic Translation

We describe a sterile pericarditis model in minipigs to study atrial myopathy and atrial fibrillation (AF). We present surgical and anesthetic techniques, strategies for vascular access, and a protocol to study the inducibility of AF.

Tags

Sterile PericarditisAachener MinipigsAtrial MyopathyAtrial FibrillationLarge Animal ModelPathogenesisElectrophysiology StudiesAnatomyPhysiologyPre-clinical Drug DiscoveryPressure Conducting SystemFemoral ArteryInternal Jugular VeinCatheterizationSternotomy

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