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Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
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Genetics
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JoVE Journal Genetics
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

DOI:
10.3791/63115-v

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08:03 min

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December 07, 2021

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, ,
1Department of Computer Science and Engineering,University of Nebraska-Lincoln, 2Department of Food Science and Technology,University of Nebraska-Lincoln, 3Nebraska Food for Health Center,University of Nebraska-Lincoln

Chapters

  • 00:04Introduction
  • 02:23Conduct Analyses and Generate Visualizations
  • 05:17Results: Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Salmonella enterica
  • 06:58Conclusion

Summary

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This analytical computational platform provides practical guidance for microbiologists, ecologists, and epidemiologists interested in bacterial population genomics. Specifically, the work presented here demonstrated how to perform: i) phylogeny-guided mapping of hierarchical genotypes; ii) frequency-based analysis of genotypes; iii) kinship and clonality analyses; iv) identification of lineage differentiating accessory loci.

Tags

Heuristic MiningHierarchical GenotypesAccessory Genome LociBacterial PopulationsProkEvoComputational PlatformScalable AnalysisPan-genomic ContentGenotype MappingPathogenic LineagesPublic Health SurveillanceBacterial Population GenomicsGigi TreePhylogenetic TreeData Aggregation

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