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An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules
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An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules

An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules

DOI:
10.3791/64670-v

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05:59 min

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November 04, 2022

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, , , , , ,
1School of Pharmacy,Chengdu University of Traditional Chinese Medicine, 2School of Ethnic Medicine,Chengdu University of Traditional Chinese Medicine, 3Tibet Rhodiola Pharmaceutical Holding Co. Ltd

Chapters

  • 00:04Introduction
  • 00:48Solution Preparation and Chromatographic Condition
  • 02:30System Adaptability Test
  • 03:47In Vitro Dissolution Test
  • 04:45Results: Characterizing the Dissolution Behavior of the Index Components in Rhodiola Granules In Vitro
  • 05:26Conclusion

Summary

Automatic Translation

Automatic Translation

Here, we test the dissolution of Rhodiola granules (RG) in vitro, draw dissolution curves of salidroside, gallic acid, and ethyl gallate in ultrapure water, and fit the curves to different mathematical models. This protocol provides information and guidance for in vivo bioequivalence and in vivo-in vitro correlation studies of RG.

Tags

In Vitro DissolutionTibetan MedicineRhodiola GranulesMulti-index ComponentSalidrocideGallic AcidEthyl Gallic AcidReference SubstanceTest SampleHPLCChromatographic ConditionsLinear RelationshipStandard Curve

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