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Journal / Cancer Research / Kvantifiering av antikroppsberoende cellulär…
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Cancer Research
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JoVE Journal Cancer Research
Kvantifiering av antikroppsberoende cellulär cytotoxicitet i en tumörsfäroidmodell
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Kvantifiering av antikroppsberoende cellulär cytotoxicitet i en tumörsfäroidmodell: Ansökan om läkemedelsutveckling

Article DOI: 10.3791/65922-v • 13:19 min • April 26th, 2024
April 26th, 2024 •
1,2, 1,3, 1,3, 1, 1,4, 1,4
1Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 2Doctoral School of Molecular Medicine, University of Debrecen, 3National Academy of Scientist Education, 4HUN-REN-DE Cell Biology and Signaling Research Group

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Här presenterar vi en metod för att identifiera substanser som modulerar ADCC-mekanismen, en viktig cancercellsdödande mekanism för antitumörantikroppar. Den cytotoxiska effekten av NK-celler mäts i sfäroider av bröstcancerceller i närvaro av Trastuzumab. Bildanalys identifierar levande och döda mördar- och målceller i sfäroider.

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Cancer Research nummer 206
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