Adolfo Saiardi Medical Research Council, Laboratory for Molecular Cell Biology University College London Biography Publications Institution JoVE Articles Adolfo Saiardi has not added a biography. If you are Adolfo Saiardi and would like to personalize this page please email our Author Liaison for assistance. Publications ITPK1 is an InsP/ADP Phosphotransferase That Controls Phosphate Signaling in Arabidopsis Molecular Plant. Jul, 2021 | Pubmed ID: 34274522 A Stable Immature Lattice Packages IP for HIV Capsid Maturation Science Advances. Mar, 2021 | Pubmed ID: 33692109 Cytoplasmic Cleavage of IMPA1 3' UTR is Necessary for Maintaining Axon Integrity Cell Reports. Feb, 2021 | Pubmed ID: 33626357 IP6K3 and IPMK Variations in LOAD and Longevity: Evidence for a Multifaceted Signaling Network at the Crossroad Between Neurodegeneration and Survival Mechanisms of Ageing and Development. 04, 2021 | Pubmed ID: 33497757 Inositol Phosphate Kinases in the Eukaryote Landscape Advances in Biological Regulation. 01, 2021 | Pubmed ID: 33422459 Phytocannabinoid-dependent MTORC1 Regulation is Dependent Upon Inositol Polyphosphate Multikinase Activity British Journal of Pharmacology. 03, 2021 | Pubmed ID: 33347604 MINPP1 Prevents Intracellular Accumulation of the Chelator Inositol Hexakisphosphate and is Mutated in Pontocerebellar Hypoplasia Nature Communications. 11, 2020 | Pubmed ID: 33257696 Analysis of Inositol Phosphate Metabolism by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry Nature Communications. 11, 2020 | Pubmed ID: 33247133 IP-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery MBio. 10, 2020 | Pubmed ID: 33082258 Effects of the Putative Lithium Mimetic Ebselen on Pilocarpine-induced Neural Activity European Journal of Pharmacology. Sep, 2020 | Pubmed ID: 32687920 Interplay Between Primary Familial Brain Calcification-associated SLC20A2 and XPR1 Phosphate Transporters Requires Inositol Polyphosphates for Control of Cellular Phosphate Homeostasis The Journal of Biological Chemistry. 07, 2020 | Pubmed ID: 32393577 Inorganic Polyphosphate in Mammals: Where's Wally? Biochemical Society Transactions. 02, 2020 | Pubmed ID: 32049314 Development of a Yeast Model to Study the Contribution of Vacuolar Polyphosphate Metabolism to Lysine Polyphosphorylation The Journal of Biological Chemistry. 02, 2020 | Pubmed ID: 31844018 Dictyostelium Discoideum As a Model to Study Inositol Polyphosphates and Inorganic Polyphosphate Methods in Molecular Biology (Clifton, N.J.). 2020 | Pubmed ID: 31773570 Cellular IP Levels Limit HIV Production While Viruses That Cannot Efficiently Package IP Are Attenuated for Infection and Replication Cell Reports. 12, 2019 | Pubmed ID: 31851928 ITPK1 Mediates the Lipid-independent Synthesis of Inositol Phosphates Controlled by Metabolism Proceedings of the National Academy of Sciences of the United States of America. 12, 2019 | Pubmed ID: 31754032 ITPK1 and ITPK2 Have an Evolutionarily Conserved Phytic Acid Kinase Activity ACS Chemical Biology. 10, 2019 | Pubmed ID: 31525024 Fungal Kinases With a Sweet Tooth: Pleiotropic Roles of Their Phosphorylated Inositol Sugar Products in the Pathogenicity of Present Novel Drug Targeting Opportunities Frontiers in Cellular and Infection Microbiology. 2019 | Pubmed ID: 31380293 Harnessing C-labeled -inositol to Interrogate Inositol Phosphate Messengers by NMR Chemical Science. May, 2019 | Pubmed ID: 31191882 The Inositol Hexakisphosphate Kinases IP6K1 and -2 Regulate Human Cellular Phosphate Homeostasis, Including XPR1-mediated Phosphate Export The Journal of Biological Chemistry. 07, 2019 | Pubmed ID: 31186349 Inositol Polyphosphate Multikinase (), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity Genes. 02, 2019 | Pubmed ID: 30744060 Crosstalk Between Ras and Inositol Phosphate Signaling Revealed by Lithium Action on Inositol Monophosphatase in Schizophyllum Commune Advances in Biological Regulation. 05, 2019 | Pubmed ID: 30639095 Hydrophilic Interaction Liquid Chromatography-tandem Mass Spectrometry for the Quantitative Analysis of Mammalian-derived Inositol Poly/pyrophosphates Journal of Chromatography. A. Oct, 2018 | Pubmed ID: 30220429 Lithium and Fluoxetine Regulate the Rate of Phosphoinositide Synthesis in Neurons: a New View of Their Mechanisms of Action in Bipolar Disorder Translational Psychiatry. 08, 2018 | Pubmed ID: 30171184 Rab4A Organizes Endosomal Domains for Sorting Cargo to Lysosome-related Organelles Journal of Cell Science. 09, 2018 | Pubmed ID: 30154210 Inositol Phosphates Purification Using Titanium Dioxide Beads Bio-protocol. Aug, 2018 | Pubmed ID: 30148188 Screening a Protein Array with Synthetic Biotinylated Inorganic Polyphosphate To Define the Human PolyP-ome ACS Chemical Biology. 08, 2018 | Pubmed ID: 29924597 IP6 is an HIV Pocket Factor That Prevents Capsid Collapse and Promotes DNA Synthesis ELife. 05, 2018 | Pubmed ID: 29848441 Asp1 Bifunctional Activity Modulates Spindle Function Via Controlling Cellular Inositol Pyrophosphate Levels in Schizosaccharomyces Pombe Molecular and Cellular Biology. 05, 2018 | Pubmed ID: 29440310 Microbial Inositol Polyphosphate Metabolic Pathway As Drug Development Target Advances in Biological Regulation. 01, 2018 | Pubmed ID: 28964726 IP3-4 Kinase Arg1 Regulates Cell Wall Homeostasis and Surface Architecture to Promote Clearance of Cryptococcus Neoformans Infection in a Mouse Model Virulence. Oct, 2017 | Pubmed ID: 28976803 The Inositol Pyrophosphate Synthesis Pathway in Trypanosoma Brucei is Linked to Polyphosphate Synthesis in Acidocalcisomes Molecular Microbiology. Oct, 2017 | Pubmed ID: 28792096 Has Inositol Played Any Role in the Origin of Life? Life (Basel, Switzerland). Jun, 2017 | Pubmed ID: 28587245 Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling Topics in Current Chemistry (Cham). Feb, 2017 | Pubmed ID: 28101851 Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective Trends in Biochemical Sciences. 03, 2017 | Pubmed ID: 27876550 Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery Journal of Fungi (Basel, Switzerland). Sep, 2016 | Pubmed ID: 29376941 Protein Pyrophosphorylation: Moving Forward The Biochemical Journal. 11, 2016 | Pubmed ID: 27789744 Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels PloS One. 2016 | Pubmed ID: 27788189 Identification of a Major IP5 Kinase in Cryptococcus Neoformans Confirms That PP-IP5/IP7, Not IP6, is Essential for Virulence Scientific Reports. Apr, 2016 | Pubmed ID: 27033523 Phosphate, Inositol and Polyphosphates Biochemical Society Transactions. Feb, 2016 | Pubmed ID: 26862212 The New World of Inorganic Polyphosphates Biochemical Society Transactions. Feb, 2016 | Pubmed ID: 26862182 Developmental Accumulation of Inorganic Polyphosphate Affects Germination and Energetic Metabolism in Dictyostelium Discoideum Proceedings of the National Academy of Sciences of the United States of America. Jan, 2016 | Pubmed ID: 26755590 Why Always Lysine? The Ongoing Tale of One of the Most Modified Amino Acids Advances in Biological Regulation. Jan, 2016 | Pubmed ID: 26482291 There is No 'Conundrum' of InsP6 Open Biology. Nov, 2015 | Pubmed ID: 26581573 Fungal Inositol Pyrophosphate IP7 Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity MBio. Jun, 2015 | Pubmed ID: 26037119 Prometabolites of 5-Diphospho-myo-inositol Pentakisphosphate Angewandte Chemie (International Ed. in English). Aug, 2015 | Pubmed ID: 26014370 VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in Arabidopsis The Plant Cell. Apr, 2015 | Pubmed ID: 25901085 A Novel Method for the Purification of Inositol Phosphates from Biological Samples Reveals That No Phytate is Present in Human Plasma or Urine Open Biology. Mar, 2015 | Pubmed ID: 25808508 Protein Polyphosphorylation of Lysine Residues by Inorganic Polyphosphate Molecular Cell. Apr, 2015 | Pubmed ID: 25773596 Raman Spectroscopy Detection of Phytic Acid in Plant Seeds Reveals the Absence of Inorganic Polyphosphate Molecular Plant. May, 2015 | Pubmed ID: 25620771 Inositol Phosphates Induce DAPI Fluorescence Shift The Biochemical Journal. Jun, 2014 | Pubmed ID: 24670057 Functions of Inorganic Polyphosphates in Eukaryotic Cells: a Coat of Many Colours Biochemical Society Transactions. Feb, 2014 | Pubmed ID: 24450634 Analysis of Dictyostelium Discoideum Inositol Pyrophosphate Metabolism by Gel Electrophoresis PloS One. 2014 | Pubmed ID: 24416420 Inositol Pyrophosphates Regulate JMJD2C-dependent Histone Demethylation Proceedings of the National Academy of Sciences of the United States of America. Nov, 2013 | Pubmed ID: 24191012 Modulation of Inositol Polyphosphate Levels Regulates Neuronal Differentiation Molecular Biology of the Cell. Sep, 2013 | Pubmed ID: 23864704 Inositol Pyrophosphates: Between Signalling and Metabolism The Biochemical Journal. Jun, 2013 | Pubmed ID: 23725456 Arginine Transcriptional Response Does Not Require Inositol Phosphate Synthesis The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 22992733 How Inositol Pyrophosphates Control Cellular Phosphate Homeostasis? Advances in Biological Regulation. May, 2012 | Pubmed ID: 22781748 Cell Signalling by Inositol Pyrophosphates Sub-cellular Biochemistry. 2012 | Pubmed ID: 22374099 Influence of Inositol Pyrophosphates on Cellular Energy Dynamics Science (New York, N.Y.). Nov, 2011 | Pubmed ID: 22076377 Identification of an Evolutionarily Conserved Family of Inorganic Polyphosphate Endopolyphosphatases The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21775424 Inositol Hexakisphosphate Kinases Induce Cell Death in Huntington Disease The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21652713 IP6K Gene Identification in Plant Genomes by Tag Searching BMC Proceedings. 2011 | Pubmed ID: 21554757 Inositol Polyphosphate Multikinase is a Physiologic PI3-kinase That Activates Akt/PKB Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21220345 The Signaling Role of Inositol Hexakisphosphate Kinases (IP6Ks) Advances in Enzyme Regulation. 2011 | Pubmed ID: 21035498 Inositol Hexakisphosphate Kinases Promote Autophagy The International Journal of Biochemistry & Cell Biology. Dec, 2010 | Pubmed ID: 20883817 Synthesis of InsP7 by the Inositol Hexakisphosphate Kinase 1 (IP6K1) Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20645182 An NGF-responsive Element Targets Myo-inositol Monophosphatase-1 MRNA to Sympathetic Neuron Axons Nature Neuroscience. Mar, 2010 | Pubmed ID: 20118926 Inositol Pyrophosphate Mediated Pyrophosphorylation of AP3B1 Regulates HIV-1 Gag Release Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 19934039 Inositol Pyrophosphates Modulate Hydrogen Peroxide Signalling The Biochemical Journal. Oct, 2009 | Pubmed ID: 19614566 Inositol Pyrophosphates and Their Unique Metabolic Complexity: Analysis by Gel Electrophoresis PloS One. 2009 | Pubmed ID: 19440344 Are Inositol Pyrophosphates Signalling Molecules? Journal of Cellular Physiology. Jul, 2009 | Pubmed ID: 19326391 Inositol Hexakisphosphate Kinase Products Contain Diphosphate and Triphosphate Groups Chemistry & Biology. Mar, 2008 | Pubmed ID: 18355727 The Mood Stabilizer Valproate Inhibits Both Inositol- and Diacylglycerol-signaling Pathways in Caenorhabditis Elegans Molecular Biology of the Cell. May, 2008 | Pubmed ID: 18287529 Human ITPK1: a Reversible Inositol Phosphate Kinase/phosphatase That Links Receptor-dependent Phospholipase C to Ca2+-activated Chloride Channels Science Signaling. 2008 | Pubmed ID: 18272466 Polyunsaturated Fatty Acids Influence Synaptojanin Localization to Regulate Synaptic Vesicle Recycling Molecular Biology of the Cell. Mar, 2008 | Pubmed ID: 18094048 Inositol Polyphosphate Multikinase: Metabolic Architect of Nuclear Inositides Frontiers in Bioscience : a Journal and Virtual Library. 2008 | Pubmed ID: 17981594 Requirement of Inositol Pyrophosphates for Full Exocytotic Capacity in Pancreatic Beta Cells Science (New York, N.Y.). Nov, 2007 | Pubmed ID: 18033884 Protein Pyrophosphorylation by Inositol Pyrophosphates is a Posttranslational Event Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007 | Pubmed ID: 17873058 Inositol Pyrophosphates Get the Vip1 Treatment Cell. May, 2007 | Pubmed ID: 17512396 Extraction and Analysis of Soluble Inositol Polyphosphates from Yeast Nature Protocols. 2006 | Pubmed ID: 17406485 Inhibition of the Phosphatidylinositol 3-kinase/Akt Pathway by Inositol Pentakisphosphate Results in Antiangiogenic and Antitumor Effects Cancer Research. Sep, 2005 | Pubmed ID: 16166311 Inositol Polyphosphate Multikinase is a Nuclear PI3-kinase with Transcriptional Regulatory Activity Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005 | Pubmed ID: 16123124 Inositol Pyrophosphates Regulate Cell Death and Telomere Length Through Phosphoinositide 3-kinase-related Protein Kinases Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15665079 Inositol Hexakisphosphate Kinase-2, a Physiologic Mediator of Cell Death The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15533939 Phosphorylation of Proteins by Inositol Pyrophosphates Science (New York, N.Y.). Dec, 2004 | Pubmed ID: 15604408 Simultaneous Absence of Dopamine D1 and D2 Receptor-mediated Signaling is Lethal in Mice Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15272078 Inositol Pyrophosphates Mediate Chemotaxis in Dictyostelium Via Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Interactions Cell. Sep, 2003 | Pubmed ID: 13678580 Inositol Pyrophosphates Regulate Endocytic Trafficking Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12391334 Role of Dopamine D2-like Receptors in Cocaine Self-administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor Antagonists The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2002 | Pubmed ID: 11923462 Inositol Pyrophosphates Are Required for DNA Hyperrecombination in Protein Kinase C1 Mutant Yeast Biochemistry. Feb, 2002 | Pubmed ID: 11851397 केशिका वैद्युतकणसंचलन इलेक्ट्रोस्प्रे आयनीकरण मास स्पेक्ट्रोमेट्री द्वारा इनोसिटोल पाइरोफॉस्फेट्स की पूर्ण मात्रा Danye Qiu1, Verena B. Eisenbeis1, Adolfo Saiardi2, Henning J. Jessen1 1Institute of Organic Chemistry, University of Freiburg, 2Medical Research Council, Laboratory for Molecular Cell Biology, University College London JoVE 62847 Biochemistry गुणवत्ता Inositol Pyrophosphates की तैयारी Omar Loss1, Cristina Azevedo1, Zsolt Szijgyarto1, Daniel Bosch1, Adolfo Saiardi1 1Medical Research Council (MRC), Cell Biology Unit and Laboratory for Molecular Cell Biology, University College London JoVE 3027 Biology
केशिका वैद्युतकणसंचलन इलेक्ट्रोस्प्रे आयनीकरण मास स्पेक्ट्रोमेट्री द्वारा इनोसिटोल पाइरोफॉस्फेट्स की पूर्ण मात्रा Danye Qiu1, Verena B. Eisenbeis1, Adolfo Saiardi2, Henning J. Jessen1 1Institute of Organic Chemistry, University of Freiburg, 2Medical Research Council, Laboratory for Molecular Cell Biology, University College London JoVE 62847 Biochemistry
गुणवत्ता Inositol Pyrophosphates की तैयारी Omar Loss1, Cristina Azevedo1, Zsolt Szijgyarto1, Daniel Bosch1, Adolfo Saiardi1 1Medical Research Council (MRC), Cell Biology Unit and Laboratory for Molecular Cell Biology, University College London JoVE 3027 Biology
