Alexander Klibanov Department of Medicine University of Virginia Biography Publications Institution JoVE Articles Alexander Klibanov has not added a biography. If you are Alexander Klibanov and would like to personalize this page please email our Author Liaison for assistance. Publications From Anatomy to Functional and Molecular Biomarker Imaging and Therapy: Ultrasound Is Safe, Ultrafast, Portable, and Inexpensive Investigative Radiology. Sep, 2020 | Pubmed ID: 32776766 Ultrasound Molecular Imaging of Cancer: Design and Formulation Strategies of Targeted Contrast Agents Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer. 2020 | Pubmed ID: 32594391 Targeted Ultrasound Contrast Imaging of Tumor Vasculature With Positively Charged Microbubbles Investigative Radiology. Jun, 2020 | Pubmed ID: 32569011 Augmentation of Brain Tumor Interstitial Flow Via Focused Ultrasound Promotes Brain-penetrating Nanoparticle Dispersion and Transfection Science Advances. May, 2020 | Pubmed ID: 32494662 Closed-loop Feedback Control of Microbubble Diameter from a Flow-focusing Microfluidic Device Biomicrofluidics. May, 2020 | Pubmed ID: 32454925 Sonoselective Transfection of Cerebral Vasculature Without Blood-brain Barrier Disruption Proceedings of the National Academy of Sciences of the United States of America. 03, 2020 | Pubmed ID: 32123081 Liposomal Delivery of PPARα/γ Dual Agonist Tesaglitazar in a Model of Obesity Enriches Macrophage Targeting and Limits Liver and Kidney Drug Effects Theranostics. 2020 | Pubmed ID: 31903139 Pulsed Ultrasound Attenuates the Hyperglycemic Exacerbation of Myocardial Ischemia-reperfusion Injury The Journal of Thoracic and Cardiovascular Surgery. Nov, 2019 | Pubmed ID: 31839230 Importance of Thorough Tissue and Cellular Level Characterization of Targeted Drugs in the Evaluation of Pharmacodynamic Effects PloS One. 2019 | Pubmed ID: 31725756 Monitoring Oxygenation Levels Deep in the Tumor Core: Noninvasive Imaging of Hypoxia, Now in Real-Time 3D Cancer Research. Sep, 2019 | Pubmed ID: 31519775 Validation of Normalized Singular Spectrum Area As a Classifier for Molecularly Targeted Microbubble Adherence Ultrasound in Medicine & Biology. 09, 2019 | Pubmed ID: 31227262 Correction: A Flow Focusing Microfluidic Device with an Integrated Coulter Particle Counter for Production, Counting and Size Characterization of Monodisperse Microbubbles Lab on a Chip. 05, 2019 | Pubmed ID: 31026008 Moving Toward Noninvasive, Focused Ultrasound Therapeutic Delivery of Drugs in the Brain: Prolonged Opening of Blood-Brain Barrier May Not Be Needed Radiology. May, 2019 | Pubmed ID: 30917292 Efficacy of Sonothrombolysis Using Microbubbles Produced by a Catheter-Based Microfluidic Device in a Rat Model of Ischemic Stroke Annals of Biomedical Engineering. Apr, 2019 | Pubmed ID: 30689066 Formation of Microbubbles for Targeted Ultrasound Contrast Imaging: Practical Translation Considerations Langmuir : the ACS Journal of Surfaces and Colloids. 08, 2019 | Pubmed ID: 30509068 Ultrasound Molecular Imaging for Differentiation of Benign and Malignant Tumors in Patients Quantitative Imaging in Medicine and Surgery. Dec, 2018 | Pubmed ID: 30701161 Changes in Cell Fate Determine the Regenerative and Functional Capacity of the Developing Kidney Before and After Release of Obstruction Clinical Science (London, England : 1979). 12, 2018 | Pubmed ID: 30442812 A Flow Focusing Microfluidic Device with an Integrated Coulter Particle Counter for Production, Counting and Size Characterization of Monodisperse Microbubbles Lab on a Chip. 08, 2018 | Pubmed ID: 30070301 Plectin-targeted Liposomes Enhance the Therapeutic Efficacy of a PARP Inhibitor in the Treatment of Ovarian Cancer Theranostics. 2018 | Pubmed ID: 29774075 Klf4 Has an Unexpected Protective Role in Perivascular Cells Within the Microvasculature American Journal of Physiology. Heart and Circulatory Physiology. 08, 2018 | Pubmed ID: 29631369 Targeting of Microbubbles: Contrast Agents for Ultrasound Molecular Imaging Journal of Drug Targeting. Jun - Jul, 2018 | Pubmed ID: 29258335 In Vitro Sonothrombolysis Enhancement by Transiently Stable Microbubbles Produced by a Flow-Focusing Microfluidic Device Annals of Biomedical Engineering. Feb, 2018 | Pubmed ID: 29192346 Muscle-derived Extracellular Superoxide Dismutase Inhibits Endothelial Activation and Protects Against Multiple Organ Dysfunction Syndrome in Mice Free Radical Biology & Medicine. 12, 2017 | Pubmed ID: 28982599 Evaluation of Pharmacokinetic and Pharmacodynamic Profiles of Liposomes for the Cell Type-specific Delivery of Small Molecule Drugs Nanomedicine : Nanotechnology, Biology, and Medicine. Nov, 2017 | Pubmed ID: 28754465 Focal Areas of Increased Lipid Concentration on the Coating of Microbubbles During Short Tone-burst Ultrasound Insonification PloS One. 2017 | Pubmed ID: 28686673 Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model Nano Letters. 06, 2017 | Pubmed ID: 28511006 Ultrasound Molecular Imaging of Inflammation in Mouse Abdominal Aorta Investigative Radiology. 09, 2017 | Pubmed ID: 28430714 Renal Collectrin Protects Against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II Journal of the American Society of Nephrology : JASN. Jun, 2017 | Pubmed ID: 28062568 The Use of Acoustic Radiation Force Decorrelation-Weighted Pulse Inversion for Enhanced Ultrasound Contrast Imaging Investigative Radiology. 02, 2017 | Pubmed ID: 27495188 Macrophages Redirect Phagocytosis by Non-professional Phagocytes and Influence Inflammation Nature. 11, 2016 | Pubmed ID: 27820945 Ultra-Low-Dose Ultrasound Molecular Imaging for the Detection of Angiogenesis in a Mouse Murine Tumor Model: How Little Can We See? Investigative Radiology. 12, 2016 | Pubmed ID: 27654582 Non-Invasive, Focal Disconnection of Brain Circuitry Using Magnetic Resonance-Guided Low-Intensity Focused Ultrasound to Deliver a Neurotoxin Ultrasound in Medicine & Biology. 09, 2016 | Pubmed ID: 27260243 Histamine Induces Microglia Activation and Dopaminergic Neuronal Toxicity Via H1 Receptor Activation Journal of Neuroinflammation. 06, 2016 | Pubmed ID: 27260166 Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2016 | Pubmed ID: 26961944 Targeted Gene Transfer to the Brain Via the Delivery of Brain-penetrating DNA Nanoparticles with Focused Ultrasound Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2016 | Pubmed ID: 26732553 Synthesis and Testing of Modular Dual-Modality Nanoparticles for Magnetic Resonance and Multispectral Photoacoustic Imaging Bioconjugate Chemistry. Feb, 2016 | Pubmed ID: 26603129 Co-administration of Microbubbles and Drugs in Ultrasound-Assisted Drug Delivery: Comparison with Drug-Carrying Particles Advances in Experimental Medicine and Biology. 2016 | Pubmed ID: 26486340 Size Exclusion HPLC Detection of Small-Size Impurities As a Complementary Means for Quality Analysis of Extracellular Vesicles Journal of Circulating Biomarkers. Jan-Dec, 2015 | Pubmed ID: 28936242 Regulation of L-selectin-dependent Hydrodynamic Shear Thresholding by Leukocyte Deformability and Shear Dependent Bond Number Biorheology. 2015 | Pubmed ID: 26600268 Ultrasound in Radiology: From Anatomic, Functional, Molecular Imaging to Drug Delivery and Image-Guided Therapy Investigative Radiology. Sep, 2015 | Pubmed ID: 26200224 Optical Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels With In Vivo Results Investigative Radiology. Nov, 2015 | Pubmed ID: 26135018 Development of Target-specific Liposomes for Delivering Small Molecule Drugs After Reperfused Myocardial Infarction Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2015 | Pubmed ID: 26122651 Therapy of Prostate Cancer Using a Novel Cancer Terminator Virus and a Small Molecule BH-3 Mimetic Oncotarget. May, 2015 | Pubmed ID: 25926554 Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli Immunity. Apr, 2015 | Pubmed ID: 25902482 Reducing Neointima Formation in a Swine Model with IVUS and Sirolimus Microbubbles Annals of Biomedical Engineering. Nov, 2015 | Pubmed ID: 25893508 Oscillatory Dynamics and In Vivo Photoacoustic Imaging Performance of Plasmonic Nanoparticle-Coated Microbubbles Small (Weinheim an Der Bergstrasse, Germany). Jul, 2015 | Pubmed ID: 25703465 In Vivo Imaging of Microfluidic-produced Microbubbles Biomedical Microdevices. Feb, 2015 | Pubmed ID: 25663444 Ultrasound-based Measurement of Molecular Marker Concentration in Large Blood Vessels: a Feasibility Study Ultrasound in Medicine & Biology. Jan, 2015 | Pubmed ID: 25308943 The Local Effects of Ovarian Diathermy in an Ovine Model of Polycystic Ovary Syndrome PloS One. 2014 | Pubmed ID: 25343339 Localized in Vivo Model Drug Delivery with Intravascular Ultrasound and Microbubbles Ultrasound in Medicine & Biology. Oct, 2014 | Pubmed ID: 25130449 Non-invasive Delivery of Stealth, Brain-penetrating Nanoparticles Across the Blood-brain Barrier Using MRI-guided Focused Ultrasound Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2014 | Pubmed ID: 24979210 Imaging Flow Cytometry Elucidates Limitations of Microparticle Analysis by Conventional Flow Cytometry Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Sep, 2014 | Pubmed ID: 24903900 Nucleic Acid Delivery with Microbubbles and Ultrasound Advanced Drug Delivery Reviews. Jun, 2014 | Pubmed ID: 24486388 Binding Dynamics of Targeted Microbubbles in Response to Modulated Acoustic Radiation Force Physics in Medicine and Biology. Jan, 2014 | Pubmed ID: 24374866 Synthesis and Characterization of Transiently Stable Albumin-coated Microbubbles Via a Flow-focusing Microfluidic Device Ultrasound in Medicine & Biology. Feb, 2014 | Pubmed ID: 24342914 Shear Forces from Flow Are Responsible for a Distinct Statistical Signature of Adherent Microbubbles in Large Vessels Molecular Imaging. Sep, 2013 | Pubmed ID: 23981785 MR-guided Focused Ultrasound Surgery, Present and Future Medical Physics. Aug, 2013 | Pubmed ID: 23927296 Ultrasound Contrast Materials in Cardiovascular Medicine: from Perfusion Assessment to Molecular Imaging Journal of Cardiovascular Translational Research. Oct, 2013 | Pubmed ID: 23913363 Ultrasound Prevents Renal Ischemia-reperfusion Injury by Stimulating the Splenic Cholinergic Anti-inflammatory Pathway Journal of the American Society of Nephrology : JASN. Sep, 2013 | Pubmed ID: 23907510 Phosphatidylserine Receptor BAI1 and Apoptotic Cells As New Promoters of Myoblast Fusion Nature. May, 2013 | Pubmed ID: 23615608 Ultrasound-based Molecular Imaging and Specific Gene Delivery to Mesenteric Vasculature by Endothelial Adhesion Molecule Targeted Microbubbles in a Mouse Model of Crohn's Disease Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2013 | Pubmed ID: 23142578 Ultrasound-mediated Vascular Gene Transfection by Cavitation of Endothelial-targeted Cationic Microbubbles JACC. Cardiovascular Imaging. Dec, 2012 | Pubmed ID: 23236976 Intravascular Ultrasound Catheter to Enhance Microbubble-based Drug Delivery Via Acoustic Radiation Force IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. Oct, 2012 | Pubmed ID: 23143566 Microbubbles As Ultrasound Contrast Agents for Molecular Imaging: Preparation and Application AJR. American Journal of Roentgenology. Aug, 2012 | Pubmed ID: 22826389 Markedly Enhanced Skeletal Muscle Transfection Achieved by the Ultrasound-targeted Delivery of Non-viral Gene Nanocarriers with Microbubbles Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2012 | Pubmed ID: 22800583 Monocyte And/or Macrophage Infiltration of Heart After Myocardial Infarction: MR Imaging by Using T1-shortening Liposomes Radiology. Aug, 2012 | Pubmed ID: 22723500 Nanobody-coupled Microbubbles As Novel Molecular Tracer Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2012 | Pubmed ID: 22197777 Inhibitor of Differentiation-3 Mediates High Fat Diet-induced Visceral Fat Expansion Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2012 | Pubmed ID: 22075252 Focused Ultrasound-mediated Drug Delivery from Microbubbles Reduces Drug Dose Necessary for Therapeutic Effect on Neointima Formation--brief Report Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2011 | Pubmed ID: 21960561 Microglial Cells Contribute to Endogenous Brain Defenses After Acute Neonatal Focal Stroke The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2011 | Pubmed ID: 21900578 Phagocytic Activity of Neuronal Progenitors Regulates Adult Neurogenesis Nature Cell Biology. Jul, 2011 | Pubmed ID: 21804544 Localized Ultrasound Enhances Delivery of Rapamycin from Microbubbles to Prevent Smooth Muscle Proliferation Journal of Controlled Release : Official Journal of the Controlled Release Society. Aug, 2011 | Pubmed ID: 21549778 Real-time Technique for Improving Molecular Imaging and Guiding Drug Delivery in Large Blood Vessels: in Vitro and Ex Vivo Results Molecular Imaging. Aug, 2011 | Pubmed ID: 21521555 皮下使用在模型中无重大采暖低税循环超声微泡造影剂激活脑胶质瘤生长的抑制作用。 Journal of Neurosurgery. Jun, 2011 | Pubmed ID: 21214331 An Ultrasound Contrast Agent Targeted to P-selectin Detects Activated Platelets at Supra-arterial Shear Flow Conditions Investigative Radiology. Oct, 2010 | Pubmed ID: 20808239 Analysis of in Vitro Transfection by Sonoporation Using Cationic and Neutral Microbubbles Ultrasound in Medicine & Biology. Nov, 2010 | Pubmed ID: 20800945 Targeted Gene Transfection from Microbubbles into Vascular Smooth Muscle Cells Using Focused, Ultrasound-mediated Delivery Ultrasound in Medicine & Biology. Sep, 2010 | Pubmed ID: 20800174 Ultrasound-triggered Release of Materials Entrapped in Microbubble-liposome Constructs: a Tool for Targeted Drug Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2010 | Pubmed ID: 20691227 Molecular Imaging of Atherosclerotic Plaques Targeted to Oxidized LDL Receptor LOX-1 by SPECT/CT and Magnetic Resonance Circulation. Cardiovascular Imaging. Jul, 2010 | Pubmed ID: 20442371 Focused in Vivo Delivery of Plasmid DNA to the Porcine Vascular Wall Via Intravascular Ultrasound Destruction of Microbubbles Journal of Vascular Research. 2010 | Pubmed ID: 19923850 Dual Frequency Method for Simultaneous Translation and Real-time Imaging of Ultrasound Contrast Agents Within Large Blood Vessels Ultrasound in Medicine & Biology. Dec, 2009 | Pubmed ID: 19828229 Muscle Contraction, but Not Insulin, Increases Microvascular Blood Volume in the Presence of Free Fatty Acid-induced Insulin Resistance Diabetes. Nov, 2009 | Pubmed ID: 19675134 Action at a Distance: Lengthening Adhesion Bonds with Poly(ethylene Glycol) Spacers Enhances Mechanically Stressed Affinity for Improved Vascular Targeting of Microparticles Langmuir : the ACS Journal of Surfaces and Colloids. Sep, 2009 | Pubmed ID: 19621909 Preparation of Targeted Microbubbles: Ultrasound Contrast Agents for Molecular Imaging Medical & Biological Engineering & Computing. Aug, 2009 | Pubmed ID: 19517153 纳米粒子的治疗 Arteriogenesis 的超声微泡破坏轴承碱性成纤维细胞生长因子-2 的有针对性地的开展。 Small (Weinheim an Der Bergstrasse, Germany). Oct, 2008 | Pubmed ID: 18720443 Microbubbles in Ultrasound-triggered Drug and Gene Delivery Advanced Drug Delivery Reviews. Jun, 2008 | Pubmed ID: 18486268 通过对比剂泡在浅表组织的声衰减显著减少了 Petechiae 在深部组织的生物学效应。 Investigative Radiology. May, 2008 | Pubmed ID: 18424953 超声微泡造影剂刺激治疗 Arteriogenesis 通过骨髓来源细胞 CD18 依赖招募。 Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2008 | Pubmed ID: 18403725 Ultrasound Molecular Imaging with Targeted Microbubble Contrast Agents Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology. Nov-Dec, 2007 | Pubmed ID: 18022115 BAI1 is an Engulfment Receptor for Apoptotic Cells Upstream of the ELMO/Dock180/Rac Module Nature. Nov, 2007 | Pubmed ID: 17960134 增强靶向超声造影剂使用声辐射力。 Ultrasound in Medicine & Biology. Jul, 2007 | Pubmed ID: 17445966 Microparticle Adhesive Dynamics and Rolling Mediated by Selectin-specific Antibodies Under Flow Biotechnology and Bioengineering. Feb, 2007 | Pubmed ID: 16917925 Targeted Ultrasound Contrast Agent for Molecular Imaging of Inflammation in High-shear Flow Contrast Media & Molecular Imaging. Nov-Dec, 2006 | Pubmed ID: 17191766 Effect of Microbubble Ligation to Cells on Ultrasound Signal Enhancement: Implications for Targeted Imaging Investigative Radiology. Oct, 2006 | Pubmed ID: 16971795 针对 P-选择素的变形充有气体的气泡。 Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2006 | Pubmed ID: 16887229 3D Perfusion Mapping in Post-infarct Mice Using Myocardial Contrast Echocardiography Ultrasound in Medicine & Biology. Jun, 2006 | Pubmed ID: 16785003 Microbubble Contrast Agents: Targeted Ultrasound Imaging and Ultrasound-assisted Drug-delivery Applications Investigative Radiology. Mar, 2006 | Pubmed ID: 16481920 针对黏膜汉语细胞粘附分子 (MAdCAM)-1,通过图像实验克罗恩病。 Gastroenterology. Jan, 2006 | Pubmed ID: 16401463 超声辐照微泡造影剂对新生小鼠骨骼肌中。 Ultrasound in Medicine & Biology. Oct, 2005 | Pubmed ID: 16223645 Assessment of Endogenous and Therapeutic Arteriogenesis by Contrast Ultrasound Molecular Imaging of Integrin Expression Circulation. Jun, 2005 | Pubmed ID: 15956135 Simultaneous Integrin Alphavbeta3 and Glycoprotein IIb/IIIa Inhibition Causes Reduction in Infarct Size in a Model of Acute Coronary Thrombosis and Primary Angioplasty Cardiovascular Research. Jun, 2005 | Pubmed ID: 15914120 Acoustic Radiation Force Enhances Targeted Delivery of Ultrasound Contrast Microbubbles: in Vitro Verification IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. Mar, 2005 | Pubmed ID: 15857050 Ligand-carrying Gas-filled Microbubbles: Ultrasound Contrast Agents for Targeted Molecular Imaging Bioconjugate Chemistry. Jan-Feb, 2005 | Pubmed ID: 15656569 Molecular Imaging with Targeted Ultrasound Contrast Microbubbles Ernst Schering Research Foundation Workshop. 2005 | Pubmed ID: 15524217 Microvascular Recruitment is an Early Insulin Effect That Regulates Skeletal Muscle Glucose Uptake in Vivo Diabetes. Jun, 2004 | Pubmed ID: 15161743 绑定和脱离动态微泡的针对 P-选择素控制的剪切流动下。 Journal of Controlled Release : Official Journal of the Controlled Release Society. May, 2004 | Pubmed ID: 15120903 Detection of Individual Microbubbles of Ultrasound Contrast Agents: Imaging of Free-floating and Targeted Bubbles Investigative Radiology. Mar, 2004 | Pubmed ID: 15076011 Targeted Tissue Transfection with Ultrasound Destruction of Plasmid-bearing Cationic Microbubbles Ultrasound in Medicine & Biology. Dec, 2003 | Pubmed ID: 14698343 Imaging Tumor Angiogenesis with Contrast Ultrasound and Microbubbles Targeted to Alpha(v)beta3 Circulation. Jul, 2003 | Pubmed ID: 12835208 Noninvasive Assessment of Angiogenesis by Ultrasound and Microbubbles Targeted to Alpha(v)-integrins Circulation. Jan, 2003 | Pubmed ID: 12551871 Influence of Microbubble Surface Charge on Capillary Transit and Myocardial Contrast Enhancement Journal of the American College of Cardiology. Aug, 2002 | Pubmed ID: 12204515 Detection of Individual Microbubbles of an Ultrasound Contrast Agent: Fundamental and Pulse Inversion Imaging Academic Radiology. Aug, 2002 | Pubmed ID: 12188248 Noninvasive Imaging of Myocardial Reperfusion Injury Using Leukocyte-targeted Contrast Echocardiography Circulation. Apr, 2002 | Pubmed ID: 11956115 脑回路非侵入性断开的靶向神经元损伤 Wilson Wang*1, Yanrong Zhang*2, Matthew J. Anzivino1, Edward H. Bertram3, James Woznak1,4, Alexander Klibanov5, Erik Dumont6, Max Wintermark*2, Kevin S. Lee*1,7,8 1Department of Neuroscience, University of Virginia, 2Department of Radiology, Stanford University, 3Department of Neurology, University of Virginia, 4Global Internship Program, Focused Ultrasound Foundation, 5Department of Medicine, University of Virginia, 6Image Guided Therapy, 7Department of Neurosurgery, University of Virginia, 8Center for Brain, Immunology, and Glia, University of Virginia JoVE 61271 Neuroscience
脑回路非侵入性断开的靶向神经元损伤 Wilson Wang*1, Yanrong Zhang*2, Matthew J. Anzivino1, Edward H. Bertram3, James Woznak1,4, Alexander Klibanov5, Erik Dumont6, Max Wintermark*2, Kevin S. Lee*1,7,8 1Department of Neuroscience, University of Virginia, 2Department of Radiology, Stanford University, 3Department of Neurology, University of Virginia, 4Global Internship Program, Focused Ultrasound Foundation, 5Department of Medicine, University of Virginia, 6Image Guided Therapy, 7Department of Neurosurgery, University of Virginia, 8Center for Brain, Immunology, and Glia, University of Virginia JoVE 61271 Neuroscience