Andre J. van Wijnen Department of Orthopedic Surgery Mayo Clinic Biography Publications Institution JoVE Articles Andre J. van Wijnen has not added a biography. If you are Andre J. van Wijnen and would like to personalize this page please email our Author Liaison for assistance. Publications Development of an Experimental Animal Model for Lower Back Pain by Percutaneous Injury-Induced Lumbar Facet Joint Osteoarthritis Journal of Cellular Physiology. Apr, 2015 | Pubmed ID: 25858171 Chromatin Modifiers and Histone Modifications in Bone Formation, Regeneration, and Therapeutic Intervention for Bone-related Disease Bone. Mar, 2015 | Pubmed ID: 25836763 The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation Journal of Cellular Physiology. Mar, 2015 | Pubmed ID: 25808524 Runx1 is Associated with Breast Cancer Progression in MMTV-PyMT Transgenic Mice and Its Depletion in Vitro Inhibits Migration and Invasion Journal of Cellular Physiology. Mar, 2015 | Pubmed ID: 25802202 Efficacy of Intervertebral Disc Regeneration with Stem Cells - A Systematic Review and Meta-analysis of Animal Controlled Trials Gene. Mar, 2015 | Pubmed ID: 25796605 Environmental Disruption of Circadian Rhythm Predisposes Mice to Osteoarthritis-Like Changes in Knee Joint Journal of Cellular Physiology. Feb, 2015 | Pubmed ID: 25655021 Targeting of Runx2 by MiR-135 and MiR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease Cancer Research. Apr, 2015 | Pubmed ID: 25634212 Subnuclear Domain Proteins in Cancer Cells Support the Functions of RUNX2 in the DNA Damage Response Journal of Cell Science. Feb, 2015 | Pubmed ID: 25609707 Intra-renal Delivery of Mesenchymal Stem Cells Attenuates Myocardial Injury After Reversal of Hypertension in Porcine Renovascular Disease Stem Cell Research & Therapy. Jan, 2015 | Pubmed ID: 25599803 Osteoporosis and Osteoarthritis. Preface Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25493310 Acute-phase Protein Serum Amyloid A3 is a Novel Paracrine Coupling Factor That Controls Bone Homeostasis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2015 | Pubmed ID: 25491310 Biological Strategies for Improved Osseointegration and Osteoinduction of Porous Metal Orthopedic Implants Tissue Engineering. Part B, Reviews. Apr, 2015 | Pubmed ID: 25348836 MicroRNA-146a Reduces IL-1 Dependent Inflammatory Responses in the Intervertebral Disc Gene. Jan, 2015 | Pubmed ID: 25311550 Planar Cell Polarity Aligns Osteoblast Division in Response to Substrate Strain Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Mar, 2015 | Pubmed ID: 25264362 Histone Deacetylase Inhibition Destabilizes the Multi-potent State of Uncommitted Adipose-derived Mesenchymal Stromal Cells Journal of Cellular Physiology. Jan, 2015 | Pubmed ID: 24912092 MicroRNA-mediated Survivin Control of Pluripotency Journal of Cellular Physiology. Jan, 2015 | Pubmed ID: 24891298 Intra-renal Delivery of Mesenchymal Stem Cells and Endothelial Progenitor Cells Attenuates Hypertensive Cardiomyopathy in Experimental Renovascular Hypertension Cell Transplantation. Nov, 2014 | Pubmed ID: 25420012 A Conserved Interaction That is Essential for the Biogenesis of Histone Locus Bodies The Journal of Biological Chemistry. Dec, 2014 | Pubmed ID: 25339177 MicroRNA and MRNA Cargo of Extracellular Vesicles from Porcine Adipose Tissue-derived Mesenchymal Stem Cells Gene. Nov, 2014 | Pubmed ID: 25158130 Hsa-mir-30c Promotes the Invasive Phenotype of Metastatic Breast Cancer Cells by Targeting NOV/CCN3 Cancer Cell International. 2014 | Pubmed ID: 25120384 The Bone-specific Runx2-P1 Promoter Displays Conserved Three-dimensional Chromatin Structure with the Syntenic Supt3h Promoter Nucleic Acids Research. 2014 | Pubmed ID: 25120271 CBFβ and the Leukemogenic Fusion Protein CBFβ-SMMHC Associate with Mitotic Chromosomes to Epigenetically Regulate Ribosomal Genes Journal of Cellular Biochemistry. Dec, 2014 | Pubmed ID: 25079347 Runx1 Activities in Superficial Zone Chondrocytes, Osteoarthritic Chondrocyte Clones and Response to Mechanical Loading Journal of Cellular Physiology. Jul, 2014 | Pubmed ID: 25078095 Runx2 is Required for Early Stages of Endochondral Bone Formation but Delays Final Stages of Bone Repair in Axin2-deficient Mice Bone. Sep, 2014 | Pubmed ID: 24973690 High-resolution Molecular Validation of Self-renewal and Spontaneous Differentiation in Clinical-grade Adipose-tissue Derived Human Mesenchymal Stem Cells Journal of Cellular Biochemistry. Oct, 2014 | Pubmed ID: 24905804 Epigenetic Landscape During Osteoblastogenesis Defines a Differentiation-dependent Runx2 Promoter Region Gene. Oct, 2014 | Pubmed ID: 24881813 Epigenetic Modifications and Canonical Wingless/int-1 Class (WNT) Signaling Enable Trans-differentiation of Nonosteogenic Cells into Osteoblasts The Journal of Biological Chemistry. Jul, 2014 | Pubmed ID: 24867947 Osteoblasts Protect AML Cells from SDF-1-induced Apoptosis Journal of Cellular Biochemistry. Jun, 2014 | Pubmed ID: 24851270 Digital Expression Profiling Identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 As Potential Predictive Biomarkers for Neo-adjuvant Chemotherapy Response in Paediatric Osteosarcoma PloS One. 2014 | Pubmed ID: 24835790 RUNX3 Facilitates Growth of Ewing Sarcoma Cells Journal of Cellular Physiology. Dec, 2014 | Pubmed ID: 24812032 Fidelity of Histone Gene Regulation is Obligatory for Genome Replication and Stability Molecular and Cellular Biology. Jul, 2014 | Pubmed ID: 24797072 Genomic Occupancy of Runx2 with Global Expression Profiling Identifies a Novel Dimension to Control of Osteoblastogenesis Genome Biology. 2014 | Pubmed ID: 24655370 Core Binding Factor β (CBFβ) is Retained in the Midbody During Cytokinesis Journal of Cellular Physiology. Oct, 2014 | Pubmed ID: 24648201 A Functional N-terminal Domain in C/EBPβ-LAP* is Required for Interacting with SWI/SNF and to Repress Ric-8B Gene Transcription in Osteoblasts Journal of Cellular Physiology. Oct, 2014 | Pubmed ID: 24585571 Bookmarking Target Genes in Mitosis: a Shared Epigenetic Trait of Phenotypic Transcription Factors and Oncogenes? Cancer Research. Jan, 2014 | Pubmed ID: 24408924 Heparan Sulfate Proteoglycans and Human Breast Cancer Epithelial Cell Tumorigenicity Journal of Cellular Biochemistry. May, 2014 | Pubmed ID: 24357546 Pain Assessment in Animal Models of Osteoarthritis Gene. Mar, 2014 | Pubmed ID: 24333346 The Dynamic Architectural and Epigenetic Nuclear Landscape: Developing the Genomic Almanac of Biology and Disease Journal of Cellular Physiology. Jun, 2014 | Pubmed ID: 24242872 Gene Wiki Reviews: Marrying Crowdsourcing with Traditional Peer Review Gene. Dec, 2013 | Pubmed ID: 24012870 Histone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone H4 Epigenome and Reduces Akt Phosphorylation The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 23940046 FGFR1 Signaling Stimulates Proliferation of Human Mesenchymal Stem Cells by Inhibiting the Cyclin-dependent Kinase Inhibitors P21(Waf1) and P27(Kip1) Stem Cells (Dayton, Ohio). Dec, 2013 | Pubmed ID: 23939995 The Influence of Collagen and Hyaluronan Matrices on the Delivery and Bioactivity of Bone Morphogenetic Protein-2 and Ectopic Bone Formation Acta Biomaterialia. Nov, 2013 | Pubmed ID: 23871940 A Current Review of Molecular Mechanisms Regarding Osteoarthritis and Pain Gene. Sep, 2013 | Pubmed ID: 23830938 A Germline Point Mutation in Runx1 Uncouples Its Role in Definitive Hematopoiesis from Differentiation Experimental Hematology. Nov, 2013 | Pubmed ID: 23823022 Altered Spinal MicroRNA-146a and the MicroRNA-183 Cluster Contribute to Osteoarthritic Pain in Knee Joints Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2013 | Pubmed ID: 23744481 MicroRNA-34c Inversely Couples the Biological Functions of the Runt-related Transcription Factor RUNX2 and the Tumor Suppressor P53 in Osteosarcoma The Journal of Biological Chemistry. Jul, 2013 | Pubmed ID: 23720736 MicroRNA Functions in Osteogenesis and Dysfunctions in Osteoporosis Current Osteoporosis Reports. Jun, 2013 | Pubmed ID: 23605904 Targeting Deregulated Epigenetic Control in Cancer Journal of Cellular Physiology. Nov, 2013 | Pubmed ID: 23589100 Lactoferricin Mediates Anti-inflammatory and Anti-catabolic Effects Via Inhibition of IL-1 and LPS Activity in the Intervertebral Disc Journal of Cellular Physiology. Sep, 2013 | Pubmed ID: 23460134 Oncogenic Cooperation Between PI3K/Akt Signaling and Transcription Factor Runx2 Promotes the Invasive Properties of Metastatic Breast Cancer Cells Journal of Cellular Physiology. Aug, 2013 | Pubmed ID: 23389849 Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt Antagonist Sost is Mediated by Estrogen Receptor β The Journal of Biological Chemistry. Mar, 2013 | Pubmed ID: 23362266 Bovine Lactoferricin Induces TIMP-3 Via the ERK1/2-Sp1 Axis in Human Articular Chondrocytes Gene. Mar, 2013 | Pubmed ID: 23313877 Runx2 Protein Represses Axin2 Expression in Osteoblasts and is Required for Craniosynostosis in Axin2-deficient Mice The Journal of Biological Chemistry. Feb, 2013 | Pubmed ID: 23300083 The Cancer-related Transcription Factor Runx2 Modulates Cell Proliferation in Human Osteosarcoma Cell Lines Journal of Cellular Physiology. Apr, 2013 | Pubmed ID: 22949168 Genomic Occupancy of HLH, AP1 and Runx2 Motifs Within a Nuclease Sensitive Site of the Runx2 Gene Journal of Cellular Physiology. Feb, 2013 | Pubmed ID: 22886425 Bovine Lactoferricin is Anti-inflammatory and Anti-catabolic in Human Articular Cartilage and Synovium Journal of Cellular Physiology. Feb, 2013 | Pubmed ID: 22740381 MiR-218 Directs a Wnt Signaling Circuit to Promote Differentiation of Osteoblasts and Osteomimicry of Metastatic Cancer Cells The Journal of Biological Chemistry. Dec, 2012 | Pubmed ID: 23060446 Epigenetic Mechanisms in Leukemia Advances in Biological Regulation. Sep, 2012 | Pubmed ID: 22884030 Epigenetic Control of Cell Cycle-dependent Histone Gene Expression is a Principal Component of the Abbreviated Pluripotent Cell Cycle Molecular and Cellular Biology. Oct, 2012 | Pubmed ID: 22826438 Toll-like Receptor Adaptor Signaling Molecule MyD88 on Intervertebral Disk Homeostasis: in Vitro, Ex Vivo Studies Gene. Sep, 2012 | Pubmed ID: 22692007 Hyaluronic Acid-based Hydrogels Functionalized with Heparin That Support Controlled Release of Bioactive BMP-2 Biomaterials. Sep, 2012 | Pubmed ID: 22687758 Control of Mesenchymal Lineage Progression by MicroRNAs Targeting Skeletal Gene Regulators Trps1 and Runx2 The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22544738 Species-specific Biological Effects of FGF-2 in Articular Cartilage: Implication for Distinct Roles Within the FGF Receptor Family Journal of Cellular Biochemistry. Jul, 2012 | Pubmed ID: 22415882 A RUNX2-HDAC1 Co-repressor Complex Regulates RRNA Gene Expression by Modulating UBF Acetylation Journal of Cell Science. Jun, 2012 | Pubmed ID: 22393235 MicroRNA Control of Bone Formation and Homeostasis Nature Reviews. Endocrinology. Apr, 2012 | Pubmed ID: 22290358 Biological Effects of the Plant-derived Polyphenol Resveratrol in Human Articular Cartilage and Chondrosarcoma Cells Journal of Cellular Physiology. Oct, 2012 | Pubmed ID: 22252971 Bone Marrow-derived Heparan Sulfate Potentiates the Osteogenic Activity of Bone Morphogenetic Protein-2 (BMP-2) Bone. Apr, 2012 | Pubmed ID: 22227436 Genomic Promoter Occupancy of Runt-related Transcription Factor RUNX2 in Osteosarcoma Cells Identifies Genes Involved in Cell Adhesion and Motility The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22158627 Heparan Sulfate Enhances the Self-renewal and Therapeutic Potential of Mesenchymal Stem Cells from Human Adult Bone Marrow Stem Cells and Development. Jul, 2012 | Pubmed ID: 22066689 Identification of RUNX3 As a Component of the MST/Hpo Signaling Pathway Journal of Cellular Physiology. Feb, 2012 | Pubmed ID: 21678419 Lactoferricin Mediates Anabolic and Anti-catabolic Effects in the Intervertebral Disc Journal of Cellular Physiology. Apr, 2012 | Pubmed ID: 21678402 The Rat Intervertebral Disk Degeneration Pain Model: Relationships Between Biological and Structural Alterations and Pain Arthritis Research & Therapy. 2011 | Pubmed ID: 21996269 Characterization of a New Animal Model for Evaluation and Treatment of Back Pain Due to Lumbar Facet Joint Osteoarthritis Arthritis and Rheumatism. Oct, 2011 | Pubmed ID: 21953085 The Polypyrimidine/polypurine Motif in the Mouse Mu Opioid Receptor Gene Promoter is a Supercoiling-regulatory Element Gene. Nov, 2011 | Pubmed ID: 21839154 Fibroblast Growth Factor Receptor 1 is Principally Responsible for Fibroblast Growth Factor 2-induced Catabolic Activities in Human Articular Chondrocytes Arthritis Research & Therapy. 2011 | Pubmed ID: 21835001 Runx2 Protein Expression Utilizes the Runx2 P1 Promoter to Establish Osteoprogenitor Cell Number for Normal Bone Formation The Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21676869 A Program of MicroRNAs Controls Osteogenic Lineage Progression by Targeting Transcription Factor Runx2 Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011 | Pubmed ID: 21628588 Functional Coupling of Transcription Factor HiNF-P and Histone H4 Gene Expression During Pre- and Post-natal Mouse Development Gene. Sep, 2011 | Pubmed ID: 21605641 Epigenetic Regulation of Early Osteogenesis and Mineralized Tissue Formation by a HOXA10-PBX1-associated Complex Cells, Tissues, Organs. 2011 | Pubmed ID: 21597276 TIEG1/KLF10 Modulates Runx2 Expression and Activity in Osteoblasts PloS One. 2011 | Pubmed ID: 21559363 Bookmarking the Genome: Maintenance of Epigenetic Information The Journal of Biological Chemistry. May, 2011 | Pubmed ID: 21454629 MicroRNA-146a is Linked to Pain-related Pathophysiology of Osteoarthritis Gene. Jul, 2011 | Pubmed ID: 21397669 Osteoarthritic Tissues Modulate Functional Properties of Sensory Neurons Associated with Symptomatic OA Pain Molecular Biology Reports. Nov, 2011 | Pubmed ID: 21327824 Genome-wide Screening in Human Growth Plates During Puberty in One Patient Suggests a Role for RUNX2 in Epiphyseal Maturation The Journal of Endocrinology. May, 2011 | Pubmed ID: 21307122 C/EBPβ Binds the P1 Promoter of the Runx2 Gene and Up-regulates Runx2 Transcription in Osteoblastic Cells Journal of Cellular Physiology. Nov, 2011 | Pubmed ID: 21302301 An Architectural Genetic and Epigenetic Perspective Integrative Biology : Quantitative Biosciences from Nano to Macro. Apr, 2011 | Pubmed ID: 21184003 Reprogramming the Pluripotent Cell Cycle: Restoration of an Abbreviated G1 Phase in Human Induced Pluripotent Stem (iPS) Cells Journal of Cellular Physiology. May, 2011 | Pubmed ID: 20945438 Live Cell Imaging of the Cancer-related Transcription Factor RUNX2 During Mitotic Progression Journal of Cellular Physiology. May, 2011 | Pubmed ID: 20945391 The Histone Deacetylase Inhibitor, Vorinostat, Reduces Tumor Growth at the Metastatic Bone Site and Associated Osteolysis, but Promotes Normal Bone Loss Molecular Cancer Therapeutics. Dec, 2010 | Pubmed ID: 21159607 Architectural Genetic and Epigenetic Control of Regulatory Networks: Compartmentalizing Machinery for Transcription and Chromatin Remodeling in Nuclear Microenvironments Critical Reviews in Eukaryotic Gene Expression. 2010 | Pubmed ID: 21133844 Cancer-related Ectopic Expression of the Bone-related Transcription Factor RUNX2 in Non-osseous Metastatic Tumor Cells is Linked to Cell Proliferation and Motility Breast Cancer Research : BCR. 2010 | Pubmed ID: 21029421 A Network Connecting Runx2, SATB2, and the MiR-23a~27a~24-2 Cluster Regulates the Osteoblast Differentiation Program Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 20980664 Insulin-like Growth Factor 1 Synergizes with Bone Morphogenetic Protein 7-mediated Anabolism in Bovine Intervertebral Disc Cells Arthritis and Rheumatism. Dec, 2010 | Pubmed ID: 20812336 Architectural Epigenetics: Mitotic Retention of Mammalian Transcriptional Regulatory Information Molecular and Cellular Biology. Oct, 2010 | Pubmed ID: 20696837 Subnuclear Localization and Intranuclear Trafficking of Transcription Factors Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20694661 Mitotic Bookmarking of Genes: a Novel Dimension to Epigenetic Control Nature Reviews. Genetics. Aug, 2010 | Pubmed ID: 20628351 Ribonucleoprotein Immunoprecipitation (RNP-IP): a Direct in Vivo Analysis of MicroRNA-targets Journal of Cellular Biochemistry. Jul, 2010 | Pubmed ID: 20564179 Alteration of Sensory Neurons and Spinal Response to an Experimental Osteoarthritis Pain Model Arthritis and Rheumatism. Oct, 2010 | Pubmed ID: 20556813 Synergism Between Wnt3a and Heparin Enhances Osteogenesis Via a Phosphoinositide 3-kinase/Akt/RUNX2 Pathway The Journal of Biological Chemistry. Aug, 2010 | Pubmed ID: 20547765 The Human SWI/SNF Complex Associates with RUNX1 to Control Transcription of Hematopoietic Target Genes Journal of Cellular Physiology. Nov, 2010 | Pubmed ID: 20506188 Pbx1 Represses Osteoblastogenesis by Blocking Hoxa10-mediated Recruitment of Chromatin Remodeling Factors Molecular and Cellular Biology. Jul, 2010 | Pubmed ID: 20439491 The Gene for Aromatase, a Rate-limiting Enzyme for Local Estrogen Biosynthesis, is a Downstream Target Gene of Runx2 in Skeletal Tissues Molecular and Cellular Biology. May, 2010 | Pubmed ID: 20231365 The Cleidocranial Dysplasia-related R131G Mutation in the Runt-related Transcription Factor RUNX2 Disrupts Binding to DNA but Not CBF-beta Journal of Cellular Biochemistry. May, 2010 | Pubmed ID: 20225274 Transcriptional Corepressor TLE1 Functions with Runx2 in Epigenetic Repression of Ribosomal RNA Genes Proceedings of the National Academy of Sciences of the United States of America. Mar, 2010 | Pubmed ID: 20160071 Glycosaminoglycans Modulate RANKL-induced Osteoclastogenesis Journal of Cellular Biochemistry. Apr, 2010 | Pubmed ID: 20135643 The Cancer-related Runx2 Protein Enhances Cell Growth and Responses to Androgen and TGFbeta in Prostate Cancer Cells Journal of Cellular Biochemistry. Mar, 2010 | Pubmed ID: 20082326 Dicer Inactivation in Osteoprogenitor Cells Compromises Fetal Survival and Bone Formation, While Excision in Differentiated Osteoblasts Increases Bone Mass in the Adult Mouse Developmental Biology. Apr, 2010 | Pubmed ID: 20079730 Definitive Hematopoiesis Requires Runx1 C-terminal-mediated Subnuclear Targeting and Transactivation Human Molecular Genetics. Mar, 2010 | Pubmed ID: 20035012 Transcription Factor-mediated Epigenetic Regulation of Cell Growth and Phenotype for Biological Control and Cancer Advances in Enzyme Regulation. 2010 | Pubmed ID: 19896493 Cyclin D2 and the CDK Substrate P220(NPAT) Are Required for Self-renewal of Human Embryonic Stem Cells Journal of Cellular Physiology. Feb, 2010 | Pubmed ID: 19890848 1alpha,25-dihydroxy Vitamin D(3) Induces Nuclear Matrix Association of the 1alpha,25-dihydroxy Vitamin D(3) Receptor in Osteoblasts Independently of Its Ability to Bind DNA Journal of Cellular Physiology. Feb, 2010 | Pubmed ID: 19885846 Human Embryonic Stem Cells Are Pre-mitotically Committed to Self-renewal and Acquire a Lengthened G1 Phase Upon Lineage Programming Journal of Cellular Physiology. Jan, 2010 | Pubmed ID: 19774559 Bioactive Lipids Lysophosphatidic Acid and Sphingosine 1-phosphate Mediate Breast Cancer Cell Biological Functions Through Distinct Mechanisms Oncology Research. 2009 | Pubmed ID: 20112503 Altered Runx1 Subnuclear Targeting Enhances Myeloid Cell Proliferation and Blocks Differentiation by Activating a MiR-24/MKP-7/MAPK Network Cancer Research. Nov, 2009 | Pubmed ID: 19826043 Runt-related Transcription Factor RUNX3 is a Target of MDM2-mediated Ubiquitination Cancer Research. Oct, 2009 | Pubmed ID: 19808967 Runx2, P53, and PRB Status As Diagnostic Parameters for Deregulation of Osteoblast Growth and Differentiation in a New Pre-chemotherapeutic Osteosarcoma Cell Line (OS1) Journal of Cellular Physiology. Dec, 2009 | Pubmed ID: 19746444 Impaired Cell Cycle Regulation of the Osteoblast-related Heterodimeric Transcription Factor Runx2-Cbfbeta in Osteosarcoma Cells Journal of Cellular Physiology. Dec, 2009 | Pubmed ID: 19739101 Ectopic Runx2 Expression in Mammary Epithelial Cells Disrupts Formation of Normal Acini Structure: Implications for Breast Cancer Progression Cancer Research. Sep, 2009 | Pubmed ID: 19690135 The Notch-responsive Transcription Factor Hes-1 Attenuates Osteocalcin Promoter Activity in Osteoblastic Cells Journal of Cellular Biochemistry. Oct, 2009 | Pubmed ID: 19670267 Positive Association Between Nuclear Runx2 and Oestrogen-progesterone Receptor Gene Expression Characterises a Biological Subtype of Breast Cancer European Journal of Cancer (Oxford, England : 1990). Sep, 2009 | Pubmed ID: 19632824 The Histone Gene Activator HINFP is a Nonredundant Cyclin E/CDK2 Effector During Early Embryonic Cell Cycles Proceedings of the National Academy of Sciences of the United States of America. Jul, 2009 | Pubmed ID: 19590016 SWI/SNF-independent Nuclease Hypersensitivity and an Increased Level of Histone Acetylation at the P1 Promoter Accompany Active Transcription of the Bone Master Gene Runx2 Biochemistry. Aug, 2009 | Pubmed ID: 19545172 Prostate Cancer Regulatory Networks Journal of Cellular Biochemistry. Aug, 2009 | Pubmed ID: 19492418 The Heparan Sulfate Proteoglycan (HSPG) Glypican-3 Mediates Commitment of MC3T3-E1 Cells Toward Osteogenesis Journal of Cellular Physiology. Sep, 2009 | Pubmed ID: 19479939 Survival Responses of Human Embryonic Stem Cells to DNA Damage Journal of Cellular Physiology. Sep, 2009 | Pubmed ID: 19373864 The Osteogenic Transcription Factor Runx2 Controls Genes Involved in Sterol/steroid Metabolism, Including CYP11A1 in Osteoblasts Molecular Endocrinology (Baltimore, Md.). Jun, 2009 | Pubmed ID: 19342447 Biological Functions of MiR-29b Contribute to Positive Regulation of Osteoblast Differentiation The Journal of Biological Chemistry. Jun, 2009 | Pubmed ID: 19342382 The Subnuclear Organization of Histone Gene Regulatory Proteins and 3' End Processing Factors of Normal Somatic and Embryonic Stem Cells is Compromised in Selected Human Cancer Cell Types Journal of Cellular Physiology. Jul, 2009 | Pubmed ID: 19277982 The Osteogenic Transcription Factor Runx2 Regulates Components of the Fibroblast Growth Factor/proteoglycan Signaling Axis in Osteoblasts Journal of Cellular Biochemistry. May, 2009 | Pubmed ID: 19259985 Organization, Integration, and Assembly of Genetic and Epigenetic Regulatory Machinery in Nuclear Microenvironments: Implications for Biological Control in Cancer Annals of the New York Academy of Sciences. Feb, 2009 | Pubmed ID: 19250187 Transcription-factor-mediated Epigenetic Control of Cell Fate and Lineage Commitment Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. Feb, 2009 | Pubmed ID: 19234518 Prostaglandin E2 and Its Cognate EP Receptors Control Human Adult Articular Cartilage Homeostasis and Are Linked to the Pathophysiology of Osteoarthritis Arthritis and Rheumatism. Feb, 2009 | Pubmed ID: 19180509 CDK Inhibitors Selectively Diminish Cell Cycle Controlled Activation of the Histone H4 Gene Promoter by P220NPAT and HiNF-P Journal of Cellular Physiology. May, 2009 | Pubmed ID: 19170105 A Runx2 Threshold for the Cleidocranial Dysplasia Phenotype Human Molecular Genetics. Feb, 2009 | Pubmed ID: 19028669 Co-stimulation of the Bone-related Runx2 P1 Promoter in Mesenchymal Cells by SP1 and ETS Transcription Factors at Polymorphic Purine-rich DNA Sequences (Y-repeats) The Journal of Biological Chemistry. Jan, 2009 | Pubmed ID: 19017640 Subnuclear Targeting of the Runx3 Tumor Suppressor and Its Epigenetic Association with Mitotic Chromosomes Journal of Cellular Physiology. Mar, 2009 | Pubmed ID: 19006109 Elevated Expression of Runx2 As a Key Parameter in the Etiology of Osteosarcoma Molecular Biology Reports. Jan, 2009 | Pubmed ID: 18931939 Specific Residues of RUNX2 Are Obligatory for Formation of BMP2-induced RUNX2-SMAD Complex to Promote Osteoblast Differentiation Cells, Tissues, Organs. 2009 | Pubmed ID: 18728344 Molecular Switches Involving Homeodomain Proteins, HOXA10 and RUNX2 Regulate Osteoblastogenesis Cells, Tissues, Organs. 2009 | Pubmed ID: 18701816 The Leukemogenic T(8;21) Fusion Protein AML1-ETO Controls RRNA Genes and Associates with Nucleolar-organizing Regions at Mitotic Chromosomes Journal of Cell Science. Dec, 2008 | Pubmed ID: 19001502 Staged Assembly of Histone Gene Expression Machinery at Subnuclear Foci in the Abbreviated Cell Cycle of Human Embryonic Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Nov, 2008 | Pubmed ID: 18957539 The Histone Gene Cell Cycle Regulator HiNF-P is a Unique Zinc Finger Transcription Factor with a Novel Conserved Auxiliary DNA-binding Motif Biochemistry. Nov, 2008 | Pubmed ID: 18850719 Runx2 Transcriptional Activation of Indian Hedgehog and a Downstream Bone Metastatic Pathway in Breast Cancer Cells Cancer Research. Oct, 2008 | Pubmed ID: 18829534 A MicroRNA Signature for a BMP2-induced Osteoblast Lineage Commitment Program Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18784367 Intricate Gene Regulatory Networks of Helix-loop-helix (HLH) Proteins Support Regulation of Bone-tissue Related Genes During Osteoblast Differentiation Journal of Cellular Biochemistry. Oct, 2008 | Pubmed ID: 18655182 Expression of Runx2 Transcription Factor in Non-skeletal Tissues, Sperm and Brain Journal of Cellular Physiology. Nov, 2008 | Pubmed ID: 18636555 Runx2 Regulates G Protein-coupled Signaling Pathways to Control Growth of Osteoblast Progenitors The Journal of Biological Chemistry. Oct, 2008 | Pubmed ID: 18625716 Genetic and Epigenetic Regulation in Nuclear Microenvironments for Biological Control in Cancer Journal of Cellular Biochemistry. Aug, 2008 | Pubmed ID: 18615590 In Situ Nuclear Organization of Regulatory Machinery Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18463823 Chromatin Immunoprecipitation Assays: Application of ChIP-on-chip for Defining Dynamic Transcriptional Mechanisms in Bone Cells Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18463819 Phenotypic Transcription Factors Epigenetically Mediate Cell Growth Control Proceedings of the National Academy of Sciences of the United States of America. May, 2008 | Pubmed ID: 18445650 MicroRNAs 221 and 222 Bypass Quiescence and Compromise Cell Survival Cancer Research. Apr, 2008 | Pubmed ID: 18413744 Vitamin D Control of Gene Expression: Temporal and Spatial Parameters for Organization of the Regulatory Machinery Critical Reviews in Eukaryotic Gene Expression. 2008 | Pubmed ID: 18304030 Structural Coupling of Smad and Runx2 for Execution of the BMP2 Osteogenic Signal The Journal of Biological Chemistry. Mar, 2008 | Pubmed ID: 18204048 P68 (Ddx5) Interacts with Runx2 and Regulates Osteoblast Differentiation Journal of Cellular Biochemistry. Apr, 2008 | Pubmed ID: 17960593 1alpha,25-dihydroxy Vitamin D3-enhanced Expression of the Osteocalcin Gene Involves Increased Promoter Occupancy of Basal Transcription Regulators and Gradual Recruitment of the 1alpha,25-dihydroxy Vitamin D3 Receptor-SRC-1 Coactivator Complex Journal of Cellular Physiology. Mar, 2008 | Pubmed ID: 17786964 Runx2 Deficiency and Defective Subnuclear Targeting Bypass Senescence to Promote Immortalization and Tumorigenic Potential Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007 | Pubmed ID: 18077419 The HiNF-P/p220NPAT Cell Cycle Signaling Pathway Controls Nonhistone Target Genes Cancer Research. Nov, 2007 | Pubmed ID: 17974976 Cell Cycle Related Modulations in Runx2 Protein Levels Are Independent of Lymphocyte Enhancer-binding Factor 1 (Lef1) in Proliferating Osteoblasts Journal of Molecular Histology. Oct, 2007 | Pubmed ID: 17885813 Transcriptional Activation of the Histone Nuclear Factor P (HiNF-P) Gene by HiNF-P and Its Cyclin E/CDK2 Responsive Co-factor P220NPAT Defines a Novel Autoregulatory Loop at the G1/S Phase Transition Gene. Nov, 2007 | Pubmed ID: 17826007 Basic Fibroblast Growth Factor Activates the MAPK and NFkappaB Pathways That Converge on Elk-1 to Control Production of Matrix Metalloproteinase-13 by Human Adult Articular Chondrocytes The Journal of Biological Chemistry. Oct, 2007 | Pubmed ID: 17724016 Nucleosome Organization and Targeting of SWI/SNF Chromatin-remodeling Complexes: Contributions of the DNA Sequence Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. Aug, 2007 | Pubmed ID: 17713577 The Interactome of the Histone Gene Regulatory Factor HiNF-P Suggests Novel Cell Cycle Related Roles in Transcriptional Control and RNA Processing Journal of Cellular Biochemistry. Sep, 2007 | Pubmed ID: 17577209 Cell Cycle Dependent Phosphorylation and Subnuclear Organization of the Histone Gene Regulator P220(NPAT) in Human Embryonic Stem Cells Journal of Cellular Physiology. Oct, 2007 | Pubmed ID: 17520687 Cooperation Between P27 and P107 During Endochondral Ossification Suggests a Genetic Pathway Controlled by P27 and P130 Molecular and Cellular Biology. Jul, 2007 | Pubmed ID: 17502351 Organization of Transcriptional Regulatory Machinery in Nuclear Microenvironments: Implications for Biological Control and Cancer Advances in Enzyme Regulation. 2007 | Pubmed ID: 17363043 Mitotic Retention of Gene Expression Patterns by the Cell Fate-determining Transcription Factor Runx2 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2007 | Pubmed ID: 17360627 HOXA10 Controls Osteoblastogenesis by Directly Activating Bone Regulatory and Phenotypic Genes Molecular and Cellular Biology. May, 2007 | Pubmed ID: 17325044 Basic Fibroblast Growth Factor Stimulates Matrix Metalloproteinase-13 Via the Molecular Cross-talk Between the Mitogen-activated Protein Kinases and Protein Kinase Cdelta Pathways in Human Adult Articular Chondrocytes The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17311929 An Architectural Perspective of Vitamin D Responsiveness Archives of Biochemistry and Biophysics. Apr, 2007 | Pubmed ID: 17288986 Chromatin Remodeling by SWI/SNF Results in Nucleosome Mobilization to Preferential Positions in the Rat Osteocalcin Gene Promoter The Journal of Biological Chemistry. Mar, 2007 | Pubmed ID: 17272279 Mitotic Occupancy and Lineage-specific Transcriptional Control of RRNA Genes by Runx2 Nature. Jan, 2007 | Pubmed ID: 17251981 The 1alpha,25-dihydroxy Vitamin D3 Receptor Preferentially Recruits the Coactivator SRC-1 During Up-regulation of the Osteocalcin Gene The Journal of Steroid Biochemistry and Molecular Biology. Mar, 2007 | Pubmed ID: 17218095 Mitotic Control of RUNX2 Phosphorylation by Both CDK1/cyclin B Kinase and PP1/PP2A Phosphatase in Osteoblastic Cells Journal of Cellular Biochemistry. Apr, 2007 | Pubmed ID: 17171635 HiNF-P is a Bifunctional Regulator of Cell Cycle Controlled Histone H4 Gene Transcription Journal of Cellular Biochemistry. May, 2007 | Pubmed ID: 17163457 Establishment of Histone Gene Regulation and Cell Cycle Checkpoint Control in Human Embryonic Stem Cells Journal of Cellular Physiology. Feb, 2007 | Pubmed ID: 17096384 Heparan Sulfate Regulates the Anabolic Activity of MC3T3-E1 Preosteoblast Cells by Induction of Runx2 Journal of Cellular Physiology. Jan, 2007 | Pubmed ID: 17051597 Reconstitution of Runx2/Cbfa1-null Cells Identifies a Requirement for BMP2 Signaling Through a Runx2 Functional Domain During Osteoblast Differentiation Journal of Cellular Biochemistry. Feb, 2007 | Pubmed ID: 16927309 The Histone Gene Transcription Factor HiNF-P Stabilizes Its Cell Cycle Regulatory Co-activator P220NPAT Biochemistry. Dec, 2006 | Pubmed ID: 17176114 BMP2 Commitment to the Osteogenic Lineage Involves Activation of Runx2 by DLX3 and a Homeodomain Transcriptional Network The Journal of Biological Chemistry. Dec, 2006 | Pubmed ID: 17060321 Networks and Hubs for the Transcriptional Control of Osteoblastogenesis Reviews in Endocrine & Metabolic Disorders. Jun, 2006 | Pubmed ID: 17051438 An Architectural Perspective of Cell-cycle Control at the G1/S Phase Cell-cycle Transition Journal of Cellular Physiology. Dec, 2006 | Pubmed ID: 17001681 Alterations in Intranuclear Localization of Runx2 Affect Biological Activity Journal of Cellular Physiology. Dec, 2006 | Pubmed ID: 16972259 Self-renewal of Human Embryonic Stem Cells is Supported by a Shortened G1 Cell Cycle Phase Journal of Cellular Physiology. Dec, 2006 | Pubmed ID: 16972248 Sulfated Glycosaminoglycans Mediate the Effects of FGF2 on the Osteogenic Potential of Rat Calvarial Osteoprogenitor Cells Journal of Cellular Physiology. Dec, 2006 | Pubmed ID: 16972247 Chromatin Remodeling and Transcriptional Activity of the Bone-specific Osteocalcin Gene Require CCAAT/enhancer-binding Protein Beta-dependent Recruitment of SWI/SNF Activity The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16772287 VRK1 Signaling Pathway in the Context of the Proliferation Phenotype in Head and Neck Squamous Cell Carcinoma Molecular Cancer Research : MCR. Mar, 2006 | Pubmed ID: 16547155 The Bone-related Zn Finger Transcription Factor Osterix Promotes Proliferation of Mesenchymal Cells Gene. Jan, 2006 | Pubmed ID: 16314050 Four Novel RUNX2 Mutations Including a Splice Donor Site Result in the Cleidocranial Dysplasia Phenotype Journal of Cellular Physiology. Apr, 2006 | Pubmed ID: 16270353 Lymphocyte Enhancer-binding Factor 1 (Lef1) Inhibits Terminal Differentiation of Osteoblasts Journal of Cellular Biochemistry. Apr, 2006 | Pubmed ID: 16267835 Microtubule-dependent Nuclear-cytoplasmic Shuttling of Runx2 Journal of Cellular Physiology. Feb, 2006 | Pubmed ID: 16110492 Brg1, the ATPase Subunit of the SWI/SNF Chromatin Remodeling Complex, is Required for Myeloid Differentiation to Granulocytes Journal of Cellular Physiology. Jan, 2006 | Pubmed ID: 15965950 The Runx2 Osteogenic Transcription Factor Regulates Matrix Metalloproteinase 9 in Bone Metastatic Cancer Cells and Controls Cell Invasion Molecular and Cellular Biology. Oct, 2005 | Pubmed ID: 16166639 Subnuclear Targeting of Runx1 is Required for Synergistic Activation of the Myeloid Specific M-CSF Receptor Promoter by PU.1 Journal of Cellular Biochemistry. Nov, 2005 | Pubmed ID: 16149049 Combinatorial Organization of the Transcriptional Regulatory Machinery in Biological Control and Cancer Advances in Enzyme Regulation. 2005 | Pubmed ID: 16135382 Coordinate Control and Selective Expression of the Full Complement of Replication-dependent Histone H4 Genes in Normal and Cancer Cells The Journal of Biological Chemistry. Nov, 2005 | Pubmed ID: 16131487 Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression The Journal of Biological Chemistry. Sep, 2005 | Pubmed ID: 16043491 HiNF-P Directly Links the Cyclin E/CDK2/p220NPAT Pathway to Histone H4 Gene Regulation at the G1/S Phase Cell Cycle Transition Molecular and Cellular Biology. Jul, 2005 | Pubmed ID: 15988025 Point Mutation in AML1 Disrupts Subnuclear Targeting, Prevents Myeloid Differentiation, and Effects a Transformation-like Phenotype Proceedings of the National Academy of Sciences of the United States of America. May, 2005 | Pubmed ID: 15870195 Organization of Transcriptional Regulatory Machinery in Osteoclast Nuclei: Compartmentalization of Runx1 Journal of Cellular Physiology. Sep, 2005 | Pubmed ID: 15828028 אדם Dupuytren של Sofia Karkampouna1, Peter Kloen2, Miryam C. Obdeijn3, Scott M. Riester4, Andre J. van Wijnen4,5, Marianna Kruithof-de Julio1,6 1Department of Molecular Cell Biology, Cancer Genomics Centre and Centre for Biomedical Genetics, Leiden University Medical Center, 2Department of Orthopedic Surgery, Academic Medical Center, 3Department of Plastic, Reconstructive and Hand Surgery, Academic Medical Center, 4Department of Orthopedic Surgery, Mayo Clinic, 5Department of Biochemistry and Molecular Biology, Mayo Clinic, 6Department of Dermatology, Leiden University Medical Center JoVE 52534 Medicine
אדם Dupuytren של Sofia Karkampouna1, Peter Kloen2, Miryam C. Obdeijn3, Scott M. Riester4, Andre J. van Wijnen4,5, Marianna Kruithof-de Julio1,6 1Department of Molecular Cell Biology, Cancer Genomics Centre and Centre for Biomedical Genetics, Leiden University Medical Center, 2Department of Orthopedic Surgery, Academic Medical Center, 3Department of Plastic, Reconstructive and Hand Surgery, Academic Medical Center, 4Department of Orthopedic Surgery, Mayo Clinic, 5Department of Biochemistry and Molecular Biology, Mayo Clinic, 6Department of Dermatology, Leiden University Medical Center JoVE 52534 Medicine