Andrew L. Kung Division of Pediatric Hematology/Oncology/Stem Cell Transplantation Columbia University Medical Center Biography Publications Institution JoVE Articles Andrew L. Kung has not added a biography. If you are Andrew L. Kung and would like to personalize this page please email our Author Liaison for assistance. Publications Differential Disruption of EWS-FLI1 Binding by DNA-Binding Agents PloS One. 2013 | Pubmed ID: 23894528 Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase As a Target in LKB1-Mutant Lung Cancer Cancer Discovery. Aug, 2013 | Pubmed ID: 23715154 Selective HDAC1/HDAC2 Inhibitors Induce Neuroblastoma Differentiation Chemistry & Biology. May, 2013 | Pubmed ID: 23706636 AML1-ETO Mediates Hematopoietic Self-renewal and Leukemogenesis Through a COX/β-catenin Signaling Pathway Blood. Jun, 2013 | Pubmed ID: 23645839 High-throughput Tyrosine Kinase Activity Profiling Identifies FAK As a Candidate Therapeutic Target in Ewing Sarcoma Cancer Research. May, 2013 | Pubmed ID: 23536552 Oncogenic BRAF Regulates Oxidative Metabolism Via PGC1α and MITF Cancer Cell. Mar, 2013 | Pubmed ID: 23477830 Complementary Genomic Screens Identify SERCA As a Therapeutic Target in NOTCH1 Mutated Cancer Cancer Cell. Mar, 2013 | Pubmed ID: 23434461 Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition Cancer Discovery. Mar, 2013 | Pubmed ID: 23430699 Shikonin, a Natural Product from the Root of Lithospermum Erythrorhizon, is a Cytotoxic DNA-binding Agent European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Feb, 2013 | Pubmed ID: 23422689 KPT-330 Inhibitor of CRM1 (XPO1)-mediated Nuclear Export Has Selective Anti-leukaemic Activity in Preclinical Models of T-cell Acute Lymphoblastic Leukaemia and Acute Myeloid Leukaemia British Journal of Haematology. Apr, 2013 | Pubmed ID: 23373539 Vascular Endothelial Growth Factor C is Increased in Endometrium and Promotes Endothelial Functions, Vascular Permeability and Angiogenesis and Growth of Endometriosis Angiogenesis. Jan, 2013 | Pubmed ID: 23334337 The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations Genes & Cancer. Jul, 2012 | Pubmed ID: 23264850 In Vivo Fluorescent Labeling of Tumor Cells with the HaloTag® Technology Current Chemical Genomics. 2012 | Pubmed ID: 23115613 The Requirement for Cyclin D Function in Tumor Maintenance Cancer Cell. Oct, 2012 | Pubmed ID: 23079655 In Vivo Imaging of Inflammatory Phagocytes Chemistry & Biology. Sep, 2012 | Pubmed ID: 22999887 Integrative Analysis Reveals an Outcome-associated and Targetable Pattern of P53 and Cell Cycle Deregulation in Diffuse Large B Cell Lymphoma Cancer Cell. Sep, 2012 | Pubmed ID: 22975378 Targeted Disruption of the BCL9/β-catenin Complex Inhibits Oncogenic Wnt Signaling Science Translational Medicine. Aug, 2012 | Pubmed ID: 22914623 BET Bromodomain Inhibition Targets Both C-Myc and IL7R in High-risk Acute Lymphoblastic Leukemia Blood. Oct, 2012 | Pubmed ID: 22904298 Autocrine Activation of the MET Receptor Tyrosine Kinase in Acute Myeloid Leukemia Nature Medicine. Jul, 2012 | Pubmed ID: 22683780 A Stapled BIM Peptide Overcomes Apoptotic Resistance in Hematologic Cancers The Journal of Clinical Investigation. Jun, 2012 | Pubmed ID: 22622039 Chemical Genomics Identifies Small-molecule MCL1 Repressors and BCL-xL As a Predictor of MCL1 Dependency Cancer Cell. Apr, 2012 | Pubmed ID: 22516262 A Murine Lung Cancer Co-clinical Trial Identifies Genetic Modifiers of Therapeutic Response Nature. Mar, 2012 | Pubmed ID: 22425996 Hypoxia Promotes Dissemination of Multiple Myeloma Through Acquisition of Epithelial to Mesenchymal Transition-like Features Blood. Jun, 2012 | Pubmed ID: 22394600 Anti-inflammatory Properties of Histone Deacetylase Inhibitors: a Mechanistic Study The Journal of Trauma and Acute Care Surgery. Feb, 2012 | Pubmed ID: 22327976 The Intersection of Genetic and Chemical Genomic Screens Identifies GSK-3α As a Target in Human Acute Myeloid Leukemia The Journal of Clinical Investigation. Mar, 2012 | Pubmed ID: 22326953 Incongruity of Imaging Using Fluorescent 2-DG Conjugates Compared to 18F-FDG in Preclinical Cancer Models Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Oct, 2012 | Pubmed ID: 22302178 Genetic Resistance to JAK2 Enzymatic Inhibitors is Overcome by HSP90 Inhibition The Journal of Experimental Medicine. Feb, 2012 | Pubmed ID: 22271575 Preclinical Activity, Pharmacodynamic, and Pharmacokinetic Properties of a Selective HDAC6 Inhibitor, ACY-1215, in Combination with Bortezomib in Multiple Myeloma Blood. Mar, 2012 | Pubmed ID: 22262760 Molecular and Cellular Effects of NEDD8-activating Enzyme Inhibition in Myeloma Molecular Cancer Therapeutics. Apr, 2012 | Pubmed ID: 22246439 P-selectin Glycoprotein Ligand Regulates the Interaction of Multiple Myeloma Cells with the Bone Marrow Microenvironment Blood. Feb, 2012 | Pubmed ID: 22096244 Mice Heterozygous for CREB Binding Protein Are Hypersensitive to γ-radiation and Invariably Develop Myelodysplastic/myeloproliferative Neoplasm Experimental Hematology. Dec, 2011 | Pubmed ID: 22198154 Hypoxia-induced Transcriptional Repression of the Melanoma-associated Oncogene MITF Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21949374 Inactivation of a Single Copy of Crebbp Selectively Alters Pre-mRNA Processing in Mouse Hematopoietic Stem Cells PloS One. 2011 | Pubmed ID: 21901164 BET Bromodomain Inhibition As a Therapeutic Strategy to Target C-Myc Cell. Sep, 2011 | Pubmed ID: 21889194 Green Tea Epigallocatechin-3-gallate Inhibits Angiogenesis and Suppresses Vascular Endothelial Growth Factor C/vascular Endothelial Growth Factor Receptor 2 Expression and Signaling in Experimental Endometriosis in Vivo Fertility and Sterility. Oct, 2011 | Pubmed ID: 21821246 High-level IGF1R Expression is Required for Leukemia-initiating Cell Activity in T-ALL and is Supported by Notch Signaling The Journal of Experimental Medicine. Aug, 2011 | Pubmed ID: 21807868 A Class of Human Proteins That Deliver Functional Proteins into Mammalian Cells in Vitro and in Vivo Chemistry & Biology. Jul, 2011 | Pubmed ID: 21802004 Microenvironmental Influence on Pre-clinical Activity of Polo-like Kinase Inhibition in Multiple Myeloma: Implications for Clinical Translation PloS One. 2011 | Pubmed ID: 21750699 MLL-rearranged Leukemia is Dependent on Aberrant H3K79 Methylation by DOT1L Cancer Cell. Jul, 2011 | Pubmed ID: 21741597 Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-molecule DOT1L Inhibitor Cancer Cell. Jul, 2011 | Pubmed ID: 21741596 A Small-molecule IAP Inhibitor Overcomes Resistance to Cytotoxic Therapies in Malignant Gliomas in Vitro and in Vivo Neuro-oncology. Aug, 2011 | Pubmed ID: 21724651 Crebbp Haploinsufficiency in Mice Alters the Bone Marrow Microenvironment, Leading to Loss of Stem Cells and Excessive Myelopoiesis Blood. Jul, 2011 | Pubmed ID: 21555743 Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming Cancer Research. Apr, 2011 | Pubmed ID: 21447744 SCF(FBW7) Regulates Cellular Apoptosis by Targeting MCL1 for Ubiquitylation and Destruction Nature. Mar, 2011 | Pubmed ID: 21368833 Optical Techniques for Tracking Multiple Myeloma Engraftment, Growth, and Response to Therapy Journal of Biomedical Optics. Jan-Feb, 2011 | Pubmed ID: 21280893 Lonafarnib (SCH66336) Improves the Activity of Temozolomide and Radiation for Orthotopic Malignant Gliomas Journal of Neuro-oncology. Aug, 2011 | Pubmed ID: 21246394 A Stapled P53 Helix Overcomes HDMX-mediated Suppression of P53 Cancer Cell. Nov, 2010 | Pubmed ID: 21075307 Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene Cancer Research. Dec, 2010 | Pubmed ID: 20952506 Selective Inhibition of BET Bromodomains Nature. Dec, 2010 | Pubmed ID: 20871596 Discovery and Characterization of Novel Mutant FLT3 Kinase Inhibitors Molecular Cancer Therapeutics. Sep, 2010 | Pubmed ID: 20807780 Discovery of a Small-molecule Type II Inhibitor of Wild-type and Gatekeeper Mutants of BCR-ABL, PDGFRalpha, Kit, and Src Kinases: Novel Type II Inhibitor of Gatekeeper Mutants Blood. May, 2010 | Pubmed ID: 20299508 Tumor Cell-specific Bioluminescence Platform to Identify Stroma-induced Changes to Anticancer Drug Activity Nature Medicine. Apr, 2010 | Pubmed ID: 20228816 An Activated ErbB3/NRG1 Autocrine Loop Supports in Vivo Proliferation in Ovarian Cancer Cells Cancer Cell. Mar, 2010 | Pubmed ID: 20227043 Direct Inhibition of the NOTCH Transcription Factor Complex Nature. Nov, 2009 | Pubmed ID: 19907488 Preferential Binding of HIF-1 to Transcriptionally Active Loci Determines Cell-type Specific Response to Hypoxia Genome Biology. 2009 | Pubmed ID: 19828020 Systematic in Vivo Structure-function Analysis of P300 in Hematopoiesis Blood. Nov, 2009 | Pubmed ID: 19822904 CBP and P300 Are Cytoplasmic E4 Polyubiquitin Ligases for P53 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009 | Pubmed ID: 19805293 Proteomic and Genetic Approaches Identify Syk As an AML Target Cancer Cell. Oct, 2009 | Pubmed ID: 19800574 In Vivo Pharmacodynamic Imaging of Proteasome Inhibition Molecular Imaging. May-Jun, 2009 | Pubmed ID: 19723471 HIF2alpha Cooperates with RAS to Promote Lung Tumorigenesis in Mice The Journal of Clinical Investigation. Aug, 2009 | Pubmed ID: 19662677 Identification of AML1-ETO Modulators by Chemical Genomics Blood. Jun, 2009 | Pubmed ID: 19377049 Fatty Acid Synthase: a Metabolic Enzyme and Candidate Oncogene in Prostate Cancer Journal of the National Cancer Institute. Apr, 2009 | Pubmed ID: 19318631 The F-box Protein Beta-TrCp1/Fbw1a Interacts with P300 to Enhance Beta-catenin Transcriptional Activity The Journal of Biological Chemistry. May, 2009 | Pubmed ID: 19297328 Integrative Analysis of HIF Binding and Transactivation Reveals Its Role in Maintaining Histone Methylation Homeostasis Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19255431 Lipocalin 2 Promotes Breast Cancer Progression Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19237579 CXCR4 Inhibitor AMD3100 Disrupts the Interaction of Multiple Myeloma Cells with the Bone Marrow Microenvironment and Enhances Their Sensitivity to Therapy Blood. Apr, 2009 | Pubmed ID: 19139079 Glioblastoma Inhibition by Cell Surface Immunoglobulin Protein EWI-2, in Vitro and in Vivo Neoplasia (New York, N.Y.). Jan, 2009 | Pubmed ID: 19107234 Bead-based Profiling of Tyrosine Kinase Phosphorylation Identifies SRC As a Potential Target for Glioblastoma Therapy Nature Biotechnology. Jan, 2009 | Pubmed ID: 19098899 HOXA9 is Required for Survival in Human MLL-rearranged Acute Leukemias Blood. Mar, 2009 | Pubmed ID: 19056693 Desferroxamine Infusion Increases Cerebral Blood Flow: a Potential Association with Hypoxia-inducible Factor-1 Clinical Science (London, England : 1979). May, 2009 | Pubmed ID: 19014354 H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias Cancer Cell. Nov, 2008 | Pubmed ID: 18977325 Antileukemic Effects of the Novel, Mutant FLT3 Inhibitor NVP-AST487: Effects on PKC412-sensitive and -resistant FLT3-expressing Cells Blood. Dec, 2008 | Pubmed ID: 18820131 Resistance of Human Glioblastoma Multiforme Cells to Growth Factor Inhibitors is Overcome by Blockade of Inhibitor of Apoptosis Proteins The Journal of Clinical Investigation. Sep, 2008 | Pubmed ID: 18677408 Pharmacologic Suppression of MITF Expression Via HDAC Inhibitors in the Melanocyte Lineage Pigment Cell & Melanoma Research. Aug, 2008 | Pubmed ID: 18627530 Expression-based Screening Identifies the Combination of Histone Deacetylase Inhibitors and Retinoids for Neuroblastoma Differentiation Proceedings of the National Academy of Sciences of the United States of America. Jul, 2008 | Pubmed ID: 18607002 Stromal-mediated Protection of Tyrosine Kinase Inhibitor-treated BCR-ABL-expressing Leukemia Cells Molecular Cancer Therapeutics. May, 2008 | Pubmed ID: 18445657 Monoallele Deletion of CBP Leads to Pericentromeric Heterochromatin Condensation Through ESET Expression and Histone H3 (K9) Methylation Human Molecular Genetics. Jun, 2008 | Pubmed ID: 18319327 Anti-apoptosis Mechanisms in Malignant Gliomas Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jan, 2008 | Pubmed ID: 18202424 Potentiation of Antileukemic Therapies by the Dual PI3K/PDK-1 Inhibitor, BAG956: Effects on BCR-ABL- and Mutant FLT3-expressing Cells Blood. Apr, 2008 | Pubmed ID: 18184863 Therapeutic Targeting of Apoptosis Pathways in Cancer Current Opinion in Oncology. Jan, 2008 | Pubmed ID: 18043263 Potentiation of Antileukemic Therapies by Smac Mimetic, LBW242: Effects on Mutant FLT3-expressing Cells Molecular Cancer Therapeutics. Jul, 2007 | Pubmed ID: 17620426 Signature-based Small Molecule Screening Identifies Cytosine Arabinoside As an EWS/FLI Modulator in Ewing Sarcoma PLoS Medicine. Apr, 2007 | Pubmed ID: 17425403 Practices and Pitfalls of Mouse Cancer Models in Drug Discovery Advances in Cancer Research. 2007 | Pubmed ID: 17161681 Mechanisms of Regulation of CXCR4/SDF-1 (CXCL12)-dependent Migration and Homing in Multiple Myeloma Blood. Apr, 2007 | Pubmed ID: 17119115 Beneficial Effects of Combining Nilotinib and Imatinib in Preclinical Models of BCR-ABL+ Leukemias Blood. Mar, 2007 | Pubmed ID: 17068153 Targeting the AIB1 Oncogene Through Mammalian Target of Rapamycin Inhibition in the Mammary Gland Cancer Research. Dec, 2006 | Pubmed ID: 17145884 CXCR4 Inhibition Synergizes with Cytotoxic Chemotherapy in Gliomas Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2006 | Pubmed ID: 17121897 Effects of PKC412, Nilotinib, and Imatinib Against GIST-associated PDGFRA Mutants with Differential Imatinib Sensitivity Gastroenterology. Dec, 2006 | Pubmed ID: 17087936 Oncogenic MITF Dysregulation in Clear Cell Sarcoma: Defining the MiT Family of Human Cancers Cancer Cell. Jun, 2006 | Pubmed ID: 16766266 A Novel Noninvasive Model of Endometriosis for Monitoring the Efficacy of Antiangiogenic Therapy The American Journal of Pathology. Jun, 2006 | Pubmed ID: 16723720 Prolonged Dormancy of Human Liposarcoma is Associated with Impaired Tumor Angiogenesis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2006 | Pubmed ID: 16638967 Noninvasive Bioluminescence Imaging of Luciferase Expressing Intracranial U87 Xenografts: Correlation with Magnetic Resonance Imaging Determined Tumor Volume and Longitudinal Use in Assessing Tumor Growth and Antiangiogenic Treatment Effect Neurosurgery. Feb, 2006 | Pubmed ID: 16462491 Antimyeloma Activity of Heat Shock Protein-90 Inhibition Blood. Feb, 2006 | Pubmed ID: 16234364 Widespread CXCR4 Activation in Astrocytomas Revealed by Phospho-CXCR4-specific Antibodies Cancer Research. Dec, 2005 | Pubmed ID: 16357147 In Vivo Assessment of RAS-dependent Maintenance of Tumor Angiogenesis by Real-time Magnetic Resonance Imaging Cancer Research. Sep, 2005 | Pubmed ID: 16166309 A HIF1alpha Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas PLoS Genetics. Jul, 2005 | Pubmed ID: 16103922 Cyclin D1 Represses P300 Transactivation Through a Cyclin-dependent Kinase-independent Mechanism The Journal of Biological Chemistry. Aug, 2005 | Pubmed ID: 15951563 Dicer-deficient Mouse Embryonic Stem Cells Are Defective in Differentiation and Centromeric Silencing Genes & Development. Feb, 2005 | Pubmed ID: 15713842 Characterization of AMN107, a Selective Inhibitor of Native and Mutant Bcr-Abl Cancer Cell. Feb, 2005 | Pubmed ID: 15710326 Activation of Apoptosis in Vivo by a Hydrocarbon-stapled BH3 Helix Science (New York, N.Y.). Sep, 2004 | Pubmed ID: 15353804 Small Molecule Blockade of Transcriptional Coactivation of the Hypoxia-inducible Factor Pathway Cancer Cell. Jul, 2004 | Pubmed ID: 15261140 P53 Targets Simian Virus 40 Large T Antigen for Acetylation by CBP Journal of Virology. Aug, 2004 | Pubmed ID: 15254196 Inhibition of the Insulin-like Growth Factor Receptor-1 Tyrosine Kinase Activity As a Therapeutic Strategy for Multiple Myeloma, Other Hematologic Malignancies, and Solid Tumors Cancer Cell. Mar, 2004 | Pubmed ID: 15050914 Mouse Reporter Strain for Noninvasive Bioluminescent Imaging of Cells That Have Undergone Cre-mediated Recombination Molecular Imaging. Oct, 2003 | Pubmed ID: 14717328 A Small-molecule Antagonist of CXCR4 Inhibits Intracranial Growth of Primary Brain Tumors Proceedings of the National Academy of Sciences of the United States of America. Nov, 2003 | Pubmed ID: 14595012 Structural Basis for Negative Regulation of Hypoxia-inducible Factor-1alpha by CITED2 Nature Structural Biology. Jul, 2003 | Pubmed ID: 12778114 Polyubiquitination of P53 by a Ubiquitin Ligase Activity of P300 Science (New York, N.Y.). Apr, 2003 | Pubmed ID: 12690203 Inhibition of FLT3 in MLL. Validation of a Therapeutic Target Identified by Gene Expression Based Classification Cancer Cell. Feb, 2003 | Pubmed ID: 12620411 Distinct Roles for CREB-binding Protein and P300 in Hematopoietic Stem Cell Self-renewal Proceedings of the National Academy of Sciences of the United States of America. Nov, 2002 | Pubmed ID: 12397173 Structural Basis for Recruitment of CBP/p300 by Hypoxia-inducible Factor-1 Alpha Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002 | Pubmed ID: 11959990 In vivo Imaging Method to Distinguish Acute and Chronic Inflammation Jen-Chieh Tseng1, Andrew L. Kung2 1Lurie Family Imaging Center, Dana-Farber Cancer Institute, Harvard Medical School, 2Division of Pediatric Hematology/Oncology/Stem Cell Transplantation, Columbia University Medical Center JoVE 50690 Immunology and Infection
In vivo Imaging Method to Distinguish Acute and Chronic Inflammation Jen-Chieh Tseng1, Andrew L. Kung2 1Lurie Family Imaging Center, Dana-Farber Cancer Institute, Harvard Medical School, 2Division of Pediatric Hematology/Oncology/Stem Cell Transplantation, Columbia University Medical Center JoVE 50690 Immunology and Infection