Andrew Tsourkas Department of Bioengineering University of Pennsylvania Biography Publications Institution JoVE Articles Andrew Tsourkas has not added a biography. If you are Andrew Tsourkas and would like to personalize this page please email our Author Liaison for assistance. Publications Quantitative Comparison of Tumor Delivery for Multiple Targeted Nanoparticles Simultaneously by Multiplex ICP-MS Scientific Reports. 2014 | Pubmed ID: 25068300 Exploring Silver As a Contrast Agent for Contrast-enhanced Dual-energy X-ray Breast Imaging The British Journal of Radiology. Jul, 2014 | Pubmed ID: 24998157 A Novel Chitosan-Hydrogel-Based Nanoparticle Delivery System for Local Inner Ear Application Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. May, 2014 | Pubmed ID: 24836592 Facile Method for the Site-Specific, Covalent Attachment of Full-Length IgG Onto Nanoparticles Small (Weinheim an Der Bergstrasse, Germany). Apr, 2014 | Pubmed ID: 24729432 Stabilized Porous Liposomes with Encapsulated Gd-labeled Dextran As a Highly Efficient MRI Contrast Agent Chemical Communications (Cambridge, England). Mar, 2014 | Pubmed ID: 24457826 Imaging the Directed Transport of Single Engineered RNA Transcripts in Real-time Using Ratiometric Bimolecular Beacons PloS One. 2014 | Pubmed ID: 24454933 Gold-loaded Polymeric Micelles for Computed Tomography-guided Radiation Therapy Treatment and Radiosensitization ACS Nano. Jan, 2014 | Pubmed ID: 24377302 Assessment of Global Cardiac Uptake of Radiolabeled Iron Oxide Nanoparticles in Apolipoprotein-E-deficient Mice: Implications for Imaging Cardiovascular Inflammation Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Jun, 2014 | Pubmed ID: 24297372 Theranostic Gold Nanoparticles Modified for Durable Systemic Circulation Effectively and Safely Enhance the Radiation Therapy of Human Sarcoma Cells and Tumors Translational Oncology. Dec, 2013 | Pubmed ID: 24466375 Sortase-tag Expressed Protein Ligation: Combining Protein Purification and Site-specific Bioconjugation into a Single Step Analytical Chemistry. Nov, 2013 | Pubmed ID: 24111659 Gd-labeled Glycol Chitosan As a PH-responsive Magnetic Resonance Imaging Agent for Detecting Acidic Tumor Microenvironments Journal of Medicinal Chemistry. Oct, 2013 | Pubmed ID: 24044414 Quantitative Assessment of Ratiometric Bimolecular Beacons As a Tool for Imaging Single Engineered RNA Transcripts and Measuring Gene Expression in Living Cells Nucleic Acids Research. Aug, 2013 | Pubmed ID: 23814183 Selective Targeting of Brain Tumors with Gold Nanoparticle-induced Radiosensitization PloS One. 2013 | Pubmed ID: 23638079 Gd-based Macromolecules and Nanoparticles As Magnetic Resonance Contrast Agents for Molecular Imaging Current Topics in Medicinal Chemistry. 2013 | Pubmed ID: 23432004 Effect of Ligand Density, Receptor Density, and Nanoparticle Size on Cell Targeting Nanomedicine : Nanotechnology, Biology, and Medicine. Feb, 2013 | Pubmed ID: 22687896 Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities Science (New York, N.Y.). Nov, 2012 | Pubmed ID: 23161990 Biodegradable Polydisulfide Dendrimer Nanoclusters As MRI Contrast Agents ACS Nano. Nov, 2012 | Pubmed ID: 23098069 Targeted and Drug-loaded Micelles Nanomedicine (London, England). Jul, 2012 | Pubmed ID: 23019673 Enhancing the Cell Uptake of Nanoparticles Within Tumors Nanomedicine (London, England). Jul, 2012 | Pubmed ID: 23019672 Synergizing Radiation Therapy with Drug-loaded Nanovectors Nanomedicine (London, England). Jul, 2012 | Pubmed ID: 23019671 Simultaneous Quantification of Tumor Uptake for Targeted and Nontargeted Liposomes and Their Encapsulated Contents by ICPMS Analytical Chemistry. Sep, 2012 | Pubmed ID: 22882145 Improving Nanoparticle Delivery with Anti-angiogenesis Therapy Nanomedicine (London, England). Jul, 2012 | Pubmed ID: 22846089 Emerging Role of Radiolabeled Nanoparticles As an Effective Diagnostic Technique EJNMMI Research. 2012 | Pubmed ID: 22809406 Xanthine Oxidase-generated Hydrogen Peroxide is a Consequence, Not a Mediator of Cell Death The FEBS Journal. Mar, 2012 | Pubmed ID: 22230240 ICP-MS Analysis of Lanthanide-doped Nanoparticles As a Non-radiative, Multiplex Approach to Quantify Biodistribution and Blood Clearance Biomaterials. Feb, 2012 | Pubmed ID: 22100983 PH-titratable Superparamagnetic Iron Oxide for Improved Nanoparticle Accumulation in Acidic Tumor Microenvironments ACS Nano. Dec, 2011 | Pubmed ID: 22035454 Improved Tumor Targeting of Polymer-based Nanovesicles Using Polymer-lipid Blends Bioconjugate Chemistry. Oct, 2011 | Pubmed ID: 21899335 Firefly Luciferase and RLuc8 Exhibit Differential Sensitivity to Oxidative Stress in Apoptotic Cells PloS One. 2011 | Pubmed ID: 21603648 Superparamagnetic Iron Oxide-enhanced Magnetic Resonance Imaging of Neuroinflammation in a Rat Model of Radicular Pain Molecular Imaging. Jun, 2011 | Pubmed ID: 21496449 Delivery of Molecular Beacons for Live-cell Imaging and Analysis of RNA Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21431740 Quantification of MiRNA Abundance in Single Cells Using Locked Nucleic Acid-FISH and Enzyme-labeled Fluorescence Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21153374 An Intein-mediated Site-specific Click Conjugation Strategy for Improved Tumor Targeting of Nanoparticle Systems Small (Weinheim an Der Bergstrasse, Germany). Nov, 2010 | Pubmed ID: 20925038 Examination of Folate-targeted Liposomes with Encapsulated Poly(2-propylacrylic Acid) As a PH-responsive Nanoplatform for Cytosolic Drug Delivery Small (Weinheim an Der Bergstrasse, Germany). Jul, 2010 | Pubmed ID: 20564486 Ratiometric Bimolecular Beacons for the Sensitive Detection of RNA in Single Living Cells Nucleic Acids Research. Aug, 2010 | Pubmed ID: 20507905 In Vivo, Multimodal Imaging of B Cell Distribution and Response to Antibody Immunotherapy in Mice PloS One. 2010 | Pubmed ID: 20498725 Gadolinium-conjugated Dendrimer Nanoclusters As a Tumor-targeted T1 Magnetic Resonance Imaging Contrast Agent Angewandte Chemie (International Ed. in English). 2010 | Pubmed ID: 19967688 Porous Polymersomes with Encapsulated Gd-labeled Dendrimers As Highly Efficient MRI Contrast Agents Advanced Functional Materials. Dec, 2009 | Pubmed ID: 23293575 Imaging Circulating Cells and Lymphoid Tissues with Iron Oxide Nanoparticles Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2009 | Pubmed ID: 20008258 Two-photon Imaging of Multicellular Tumor Spheroids: a Novel Method for Evaluating the Efficacy of CDC25 Phosphatase Inhibitors Cancer Biology & Therapy. Dec, 2009 | Pubmed ID: 19855193 Sub-cellular Trafficking and Functionality of 2'-O-methyl and 2'-O-methyl-phosphorothioate Molecular Beacons Nucleic Acids Research. Dec, 2009 | Pubmed ID: 19820111 Comparative Analysis of Nanoparticle-antibody Conjugations: Carbodiimide Versus Click Chemistry Molecular Imaging. Jul-Aug, 2009 | Pubmed ID: 19728976 Imaging Individual MicroRNAs in Single Mammalian Cells in Situ Nucleic Acids Research. Aug, 2009 | Pubmed ID: 19515934 Fluorescent Probes for Live-cell RNA Detection Annual Review of Biomedical Engineering. 2009 | Pubmed ID: 19400712 In Vivo Imaging of Cancer Biomarkers Using Activatable Molecular Probes Cancer Biomarkers : Section A of Disease Markers. 2008 | Pubmed ID: 19126958 Assessing the Sensitivity of Commercially Available Fluorophores to the Intracellular Environment Analytical Chemistry. Oct, 2008 | Pubmed ID: 18700780 Paramagnetic Porous Polymersomes Langmuir : the ACS Journal of Surfaces and Colloids. Aug, 2008 | Pubmed ID: 18570445 Size, Charge and Concentration Dependent Uptake of Iron Oxide Particles by Non-phagocytic Cells Biomaterials. Sep, 2008 | Pubmed ID: 18533252 Efficient Cytosolic Delivery of Molecular Beacon Conjugates and Flow Cytometric Analysis of Target RNA Nucleic Acids Research. Jul, 2008 | Pubmed ID: 18503086 Iron Chelator-based Amplification Strategy for Improved Targeting of Transferrin Receptor with SPIO Cancer Biology & Therapy. Jun, 2008 | Pubmed ID: 18367876 Avoiding False-positive Signals with Nuclease-vulnerable Molecular Beacons in Single Living Cells Nucleic Acids Research. 2007 | Pubmed ID: 17702767 Suicide Gene Delivery by Calcium Phosphate Nanoparticles: a Novel Method of Targeted Therapy for Gastric Cancer Cancer Biology & Therapy. Dec, 2006 | Pubmed ID: 17224632 Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging Annals of Biomedical Engineering. Jan, 2006 | Pubmed ID: 16496086 In Vivo Imaging of Activated Endothelium Using an Anti-VCAM-1 Magnetooptical Probe Bioconjugate Chemistry. May-Jun, 2005 | Pubmed ID: 15898724 Detection of Peroxidase/H2O2-mediated Oxidation with Enhanced Yellow Fluorescent Protein Analytical Chemistry. May, 2005 | Pubmed ID: 15859603 Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle Circulation Research. Feb, 2005 | Pubmed ID: 15653572 Engineering Nanostructured Probes for Sensitive Intracellular Gene Detection Mechanics & Chemistry of Biosystems : MCB. Mar, 2004 | Pubmed ID: 16783944 Magnetic Relaxation Switch Immunosensors Detect Enantiomeric Impurities Angewandte Chemie (International Ed. in English). Apr, 2004 | Pubmed ID: 15114571 Dual FRET Molecular Beacons for MRNA Detection in Living Cells Nucleic Acids Research. 2004 | Pubmed ID: 15084672 Shedding Light on Health and Disease Using Molecular Beacons Briefings in Functional Genomics & Proteomics. Jan, 2003 | Pubmed ID: 15239884 Spectroscopic Features of Dual Fluorescence/luminescence Resonance Energy-transfer Molecular Beacons Analytical Chemistry. Aug, 2003 | Pubmed ID: 14572032 Hybridization of 2'-O-methyl and 2'-deoxy Molecular Beacons to RNA and DNA Targets Nucleic Acids Research. Mar, 2003 | Pubmed ID: 12669716 Hybridization Kinetics and Thermodynamics of Molecular Beacons Nucleic Acids Research. Feb, 2003 | Pubmed ID: 12582252 Hybridization of 2'-O-methyl and 2'-deoxy Molecular Beacons to RNA and DNA Targets Nucleic Acids Research. Dec, 2002 | Pubmed ID: 12466541 Structure-function Relationships of Shared-stem and Conventional Molecular Beacons Nucleic Acids Research. Oct, 2002 | Pubmed ID: 12364599 Echtzeit-Bildgebung von Einzel Engineered RNA-Transkripte in lebenden Zellen Mit Ratiometrische Bimolekulare Beacons Yang Song*1, Xuemei Zhang*1, Lingyan Huang2, Mark A. Behlke2, Andrew Tsourkas1 1Department of Bioengineering, University of Pennsylvania, 2Integrated DNA Technologies, Inc. JoVE 51544 Biology
Echtzeit-Bildgebung von Einzel Engineered RNA-Transkripte in lebenden Zellen Mit Ratiometrische Bimolekulare Beacons Yang Song*1, Xuemei Zhang*1, Lingyan Huang2, Mark A. Behlke2, Andrew Tsourkas1 1Department of Bioengineering, University of Pennsylvania, 2Integrated DNA Technologies, Inc. JoVE 51544 Biology