Anthony J. Koleske Department of Molecular Biophysics and Biochemistry Yale University Biography Publications Institution JoVE Articles Anthony J. Koleske has not added a biography. If you are Anthony J. Koleske and would like to personalize this page please email our Author Liaison for assistance. Publications Platelet-derived Growth Factor Receptor Beta Activates Abl2 Via Direct Binding and Phosphorylation The Journal of Biological Chemistry. 07, 2021 | Pubmed ID: 34144039 Regulation of the NMDA Receptor by Its Cytoplasmic Domains: (How) is the Tail Wagging the Dog? Neuropharmacology. 09, 2021 | Pubmed ID: 34097949 Abl2:Cortactin Interactions Regulate Dendritic Spine Stability Via Control of a Stable Filamentous Actin Pool The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 04, 2021 | Pubmed ID: 33622779 Trio Family Proteins As Regulators of Cell Migration and Morphogenesis in Development and Disease - Mechanisms and Cellular Contexts Journal of Cell Science. 02, 2021 | Pubmed ID: 33568469 Functional Interactions of Ion Channels with the Actin Cytoskeleton: Does Coupling to Dynamic Actin Regulate NMDA Receptors? The Journal of Physiology. 01, 2021 | Pubmed ID: 32034761 Crystal Structure of a Guanine Nucleotide Exchange Factor Encoded by the Scrub Typhus Pathogen Proceedings of the National Academy of Sciences of the United States of America. 12, 2020 | Pubmed ID: 33184172 Two-color Nanoscopy of Organelles for Extended Times with HIDE Probes Nature Communications. 08, 2020 | Pubmed ID: 32848153 Neural Stem Cells Direct Axon Guidance Via Their Radial Fiber Scaffold Neuron. 09, 2020 | Pubmed ID: 32707082 ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice Gastroenterology. 07, 2020 | Pubmed ID: 32171747 Regulation of MT Dynamics Via Direct Binding of an Abl Family Kinase The Journal of Cell Biology. 12, 2019 | Pubmed ID: 31699690 Integrin α5β1 Regulates PP2A Complex Assembly Through PDE4D in Atherosclerosis The Journal of Clinical Investigation. 08, 2019 | Pubmed ID: 31408443 Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits Cell Reports. 03, 2019 | Pubmed ID: 30840899 Transient Inhibition of P53 Homologs Protects Ovarian Function from Two Distinct Apoptotic Pathways Triggered by Anticancer Therapies Cell Death and Differentiation. 03, 2019 | Pubmed ID: 29988075 Abl2 is Recruited to Ventral Actin Waves Through Cytoskeletal Interactions to Promote Lamellipodium Extension Molecular Biology of the Cell. 11, 2018 | Pubmed ID: 30256707 Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function Cell Reports. 08, 2018 | Pubmed ID: 30089263 Cortactin Stabilization of Actin Requires Actin-binding Repeats and Linker, is Disrupted by Specific Substitutions, and is Independent of Nucleotide State The Journal of Biological Chemistry. 08, 2018 | Pubmed ID: 29929984 A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. 06, 2018 | Pubmed ID: 29550892 Analysis of Cellular Tyrosine Phosphorylation Via Chemical Rescue of Conditionally Active Abl Kinase Biochemistry. 02, 2018 | Pubmed ID: 29341593 The Vascular Endothelial Specific IL-4 Receptor Alpha-ABL1 Kinase Signaling Axis Regulates the Severity of IgE-mediated Anaphylactic Reactions The Journal of Allergy and Clinical Immunology. 10, 2018 | Pubmed ID: 29157947 The Repeat Region of Cortactin is Intrinsically Disordered in Solution Scientific Reports. 12, 2017 | Pubmed ID: 29196701 Corticosteroid-induced Dendrite Loss and Behavioral Deficiencies Can Be Blocked by Activation of Abl2/Arg Kinase Molecular and Cellular Neurosciences. 12, 2017 | Pubmed ID: 29107098 CNS Neurons Deposit Laminin α5 to Stabilize Synapses Cell Reports. Oct, 2017 | Pubmed ID: 29091766 Neurodevelopmental Disease-associated De Novo Mutations and Rare Sequence Variants Affect TRIO GDP/GTP Exchange Factor Activity Human Molecular Genetics. 12, 2017 | Pubmed ID: 28973398 Long-Term Live-Cell STED Nanoscopy of Primary and Cultured Cells with the Plasma Membrane HIDE Probe DiI-SiR Angewandte Chemie (International Ed. in English). 08, 2017 | Pubmed ID: 28679029 Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity ACS Chemical Neuroscience. 07, 2017 | Pubmed ID: 28418645 Phosphorylated Cortactin Recruits Vav2 Guanine Nucleotide Exchange Factor to Activate Rac3 and Promote Invadopodial Function in Invasive Breast Cancer Cells Molecular Biology of the Cell. May, 2017 | Pubmed ID: 28356423 Differential Expression of Cytoskeletal Regulatory Factors in the Adolescent Prefrontal Cortex: Implications for Cortical Development Journal of Neuroscience Research. 05, 2017 | Pubmed ID: 27735056 Arg Deficiency Does Not Influence the Course of Myelin Oligodendrocyte Glycoprotein (MOG35-55)-induced Experimental Autoimmune Encephalomyelitis Journal of Clinical & Cellular Immunology. 2016 | Pubmed ID: 34527426 Reciprocal Stabilization of ABL and TAZ Regulates Osteoblastogenesis Through Transcription Factor RUNX2 The Journal of Clinical Investigation. Dec, 2016 | Pubmed ID: 27797343 The Src Kinases Hck, Fgr and Lyn Activate Arg to Facilitate IgG-mediated Phagocytosis and Leishmania Infection Journal of Cell Science. 08, 2016 | Pubmed ID: 27358479 Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 06, 2016 | Pubmed ID: 27335408 SNARE Complex Dysfunction: A Unifying Hypothesis for Schizophrenia Biological Psychiatry. Sep, 2015 | Pubmed ID: 26296424 A Phase Ib Multiple Ascending Dose Study of the Safety, Tolerability, and Central Nervous System Availability of AZD0530 (saracatinib) in Alzheimer's Disease Alzheimer's Research & Therapy. 2015 | Pubmed ID: 25874001 Structure of the ABL2/ARG Kinase in Complex with Dasatinib Acta Crystallographica. Section F, Structural Biology Communications. Apr, 2015 | Pubmed ID: 25849507 Direct Interactions with the Integrin β1 Cytoplasmic Tail Activate the Abl2/Arg Kinase The Journal of Biological Chemistry. Mar, 2015 | Pubmed ID: 25694433 Abl2/Abl-related Gene Stabilizes Actin Filaments, Stimulates Actin Branching by Actin-related Protein 2/3 Complex, and Promotes Actin Filament Severing by Cofilin The Journal of Biological Chemistry. Feb, 2015 | Pubmed ID: 25540195 Adolescent Cocaine Exposure Simplifies Orbitofrontal Cortical Dendritic Arbors Frontiers in Pharmacology. 2014 | Pubmed ID: 25452728 ECM Receptors in Neuronal Structure, Synaptic Plasticity, and Behavior Progress in Brain Research. 2014 | Pubmed ID: 25410355 Extracellular Matrix Control of Dendritic Spine and Synapse Structure and Plasticity in Adulthood Frontiers in Neuroanatomy. 2014 | Pubmed ID: 25368556 Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase SRC Homology 2 Domains for Phosphorylated Cortactin The Journal of Biological Chemistry. Jul, 2014 | Pubmed ID: 24891505 Ablation of ErbB4 from Excitatory Neurons Leads to Reduced Dendritic Spine Density in Mouse Prefrontal Cortex The Journal of Comparative Neurology. Oct, 2014 | Pubmed ID: 24752666 Metabotropic Glutamate Receptor 5 is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein Neuron. Sep, 2013 | Pubmed ID: 24012003 Arg Kinase Signaling in Dendrite and Synapse Stabilization Pathways: Memory, Cocaine Sensitivity, and Stress The International Journal of Biochemistry & Cell Biology. Nov, 2013 | Pubmed ID: 23916785 Molecular Mechanisms of Dendrite Stability Nature Reviews. Neuroscience. Aug, 2013 | Pubmed ID: 23839597 WAVE2 Regulates Epithelial Morphology and Cadherin Isoform Switching Through Regulation of Twist and Abl PloS One. 2013 | Pubmed ID: 23691243 Integrin α3 is Required for Late Postnatal Stability of Dendrite Arbors, Dendritic Spines and Synapses, and Mouse Behavior The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2013 | Pubmed ID: 23595732 β1 Integrin Regulates Arg to Promote Invadopodial Maturation and Matrix Degradation Molecular Biology of the Cell. Jun, 2013 | Pubmed ID: 23552693 Corticosteroid-induced Neural Remodeling Predicts Behavioral Vulnerability and Resilience The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2013 | Pubmed ID: 23407965 Abl2/Arg Controls Dendritic Spine and Dendrite Arbor Stability Via Distinct Cytoskeletal Control Pathways The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2013 | Pubmed ID: 23365224 Delayed Amyloid Plaque Deposition and Behavioral Deficits in Outcrossed AβPP/PS1 Mice The Journal of Comparative Neurology. Apr, 2013 | Pubmed ID: 23047754 Arg/Abl2 Promotes Invasion and Attenuates Proliferation of Breast Cancer in Vivo Oncogene. May, 2013 | Pubmed ID: 22777352 Action Control is Mediated by Prefrontal BDNF and Glucocorticoid Receptor Binding Proceedings of the National Academy of Sciences of the United States of America. Dec, 2012 | Pubmed ID: 23185000 A Peptide Photoaffinity Probe Specific for the Active Conformation of the Abl Tyrosine Kinase Chembiochem : a European Journal of Chemical Biology. Nov, 2012 | Pubmed ID: 23081945 Met Acts Through Abl to Regulate P53 Transcriptional Outcomes and Cell Survival in the Developing Liver Journal of Hepatology. Dec, 2012 | Pubmed ID: 22889954 Arg/Abl2 Modulates the Affinity and Stoichiometry of Binding of Cortactin to F-actin Biochemistry. Aug, 2012 | Pubmed ID: 22849492 The Abl and Arg Kinases Mediate Distinct Modes of Phagocytosis and Are Required for Maximal Leishmania Infection Molecular and Cellular Biology. Aug, 2012 | Pubmed ID: 22665498 Cortactin in Cell Migration and Cancer at a Glance Journal of Cell Science. Apr, 2012 | Pubmed ID: 22566665 Arg Kinase Regulates Prefrontal Dendritic Spine Refinement and Cocaine-induced Plasticity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2012 | Pubmed ID: 22396406 Integrin β1 Signals Through Arg to Regulate Postnatal Dendritic Arborization, Synapse Density, and Behavior The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2012 | Pubmed ID: 22357865 Lysozyme Contamination Facilitates Crystallization of a Heterotrimeric Cortactin-Arg-lysozyme Complex Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Feb, 2012 | Pubmed ID: 22297987 Cortactin Phosphorylation Regulates Cell Invasion Through a PH-dependent Pathway The Journal of Cell Biology. Nov, 2011 | Pubmed ID: 22105349 ErbB4 Localization to Interneurons: Clearer Insights into Schizophrenia Pathology Biological Psychiatry. Oct, 2011 | Pubmed ID: 21924131 Invadopodia: RhoC Runs Rings Around Cofilin Current Biology : CB. Apr, 2011 | Pubmed ID: 21514509 Cell Adhesion Signaling Pathways: First Responders to Cocaine Exposure? Communicative & Integrative Biology. Jan, 2011 | Pubmed ID: 21509173 The Vacuolar-ATPase Modulates Matrix Metalloproteinase Isoforms in Human Pancreatic Cancer Laboratory Investigation; a Journal of Technical Methods and Pathology. May, 2011 | Pubmed ID: 21339745 An EGFR-Src-Arg-cortactin Pathway Mediates Functional Maturation of Invadopodia and Breast Cancer Cell Invasion Cancer Research. Mar, 2011 | Pubmed ID: 21257711 Specific Tyrosine Phosphorylation Sites on Cortactin Regulate Nck1-dependent Actin Polymerization in Invadopodia Journal of Cell Science. Nov, 2010 | Pubmed ID: 20971703 Phosphorylation by the C-Abl Protein Tyrosine Kinase Inhibits Parkin's Ubiquitination and Protective Function Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20823226 The Abl and Arg Non-receptor Tyrosine Kinases Regulate Different Zones of Stress Fiber, Focal Adhesion, and Contractile Network Localization in Spreading Fibroblasts Cytoskeleton (Hoboken, N.J.). Oct, 2010 | Pubmed ID: 20737438 Increased Dendrite Branching in AbetaPP/PS1 Mice and Elongation of Dendrite Arbors by Fasudil Administration Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20413901 Mechanisms of Synapse and Dendrite Maintenance and Their Disruption in Psychiatric and Neurodegenerative Disorders Annual Review of Neuroscience. 2010 | Pubmed ID: 20367247 Synaptic Clustering of PSD-95 is Regulated by C-Abl Through Tyrosine Phosphorylation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2010 | Pubmed ID: 20220006 Regulation of Actin Polymerization and Adhesion-dependent Cell Edge Protrusion by the Abl-related Gene (Arg) Tyrosine Kinase and N-WASp Biochemistry. Mar, 2010 | Pubmed ID: 20146487 Loss of Dendrite Stabilization by the Abl-related Gene (Arg) Kinase Regulates Behavioral Flexibility and Sensitivity to Cocaine Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009 | Pubmed ID: 19805386 Regulation of Cell Migration and Morphogenesis by Abl-family Kinases: Emerging Mechanisms and Physiological Contexts Journal of Cell Science. Oct, 2009 | Pubmed ID: 19759284 Cortactin Regulates Cofilin and N-WASp Activities to Control the Stages of Invadopodium Assembly and Maturation The Journal of Cell Biology. Aug, 2009 | Pubmed ID: 19704022 N-myristoylated C-Abl Tyrosine Kinase Localizes to the Endoplasmic Reticulum Upon Binding to an Allosteric Inhibitor The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19679652 Arg Interacts with Cortactin to Promote Adhesion-dependent Cell Edge Protrusion The Journal of Cell Biology. May, 2009 | Pubmed ID: 19414610 T Cell Survival and Function Requires the C-Abl Tyrosine Kinase Cell Cycle (Georgetown, Tex.). Dec, 2008 | Pubmed ID: 19098427 Enhancement of ABL Kinase Catalytic Efficiency by a Direct Binding Regulator is Independent of Other Regulatory Mechanisms The Journal of Biological Chemistry. Nov, 2008 | Pubmed ID: 18796434 The C-Abl Tyrosine Kinase Regulates Actin Remodeling at the Immune Synapse Blood. Jul, 2008 | Pubmed ID: 18305217 Inhibition of Rho Via Arg and P190RhoGAP in the Postnatal Mouse Hippocampus Regulates Dendritic Spine Maturation, Synapse and Dendrite Stability, and Behavior The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2007 | Pubmed ID: 17928439 Use of a Chemical Genetic Technique to Identify Myosin IIb As a Substrate of the Abl-related Gene (Arg) Tyrosine Kinase Biochemistry. Oct, 2007 | Pubmed ID: 17892306 Dissecting Kinase Signaling Pathways Drug Discovery Today. Sep, 2007 | Pubmed ID: 17826684 The Abl-related Gene Tyrosine Kinase Acts Through P190RhoGAP to Inhibit Actomyosin Contractility and Regulate Focal Adhesion Dynamics Upon Adhesion to Fibronectin Molecular Biology of the Cell. Oct, 2007 | Pubmed ID: 17652459 A Critical Role for Cortactin Phosphorylation by Abl-family Kinases in PDGF-induced Dorsal-wave Formation Current Biology : CB. Mar, 2007 | Pubmed ID: 17306540 Integrin Signaling Through Arg Activates P190RhoGAP by Promoting Its Binding to P120RasGAP and Recruitment to the Membrane Molecular Biology of the Cell. Nov, 2006 | Pubmed ID: 16971514 Integrin-mediated Dendrite Branch Maintenance Requires Abelson (Abl) Family Kinases The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2005 | Pubmed ID: 15987940 The Abl-related Gene (Arg) Requires Its F-actin-microtubule Cross-linking Activity to Regulate Lamellipodial Dynamics During Fibroblast Adhesion The Journal of Cell Biology. May, 2004 | Pubmed ID: 15138293 Adhesion-dependent Regulation of P190RhoGAP in the Developing Brain by the Abl-related Gene Tyrosine Kinase Current Biology : CB. Apr, 2004 | Pubmed ID: 15084284 Bidirectional Signaling Links the Abelson Kinases to the Platelet-derived Growth Factor Receptor Molecular and Cellular Biology. Mar, 2004 | Pubmed ID: 14993293 How Do Abl Family Kinases Regulate Cell Shape and Movement? Trends in Cell Biology. Jan, 2004 | Pubmed ID: 14729179 Do Filopodia Enable the Growth Cone to Find Its Way? Science's STKE : Signal Transduction Knowledge Environment. May, 2003 | Pubmed ID: 12759482 Two Distinct Phosphorylation Pathways Have Additive Effects on Abl Family Kinase Activation Molecular and Cellular Biology. Jun, 2003 | Pubmed ID: 12748290 Abl Family Nonreceptor Tyrosine Kinases Modulate Short-term Synaptic Plasticity Journal of Neurophysiology. Mar, 2003 | Pubmed ID: 12626632 The Abl-related Gene (Arg) Nonreceptor Tyrosine Kinase Uses Two F-actin-binding Domains to Bundle F-actin Proceedings of the National Academy of Sciences of the United States of America. Dec, 2001 | Pubmed ID: 11752434 Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation Neuron. Dec, 1998 | Pubmed ID: 9883720 מדידת דינמיקת בליטה בקצה התא במהלך ההתפשטות באמצעות מיקרוסקופיה של תאים חיים Nikola Lukic*1, Trishna Saha*1, Stefanie Lapetina1, Michal Gendler1, Gilad Lehmann1, Anthony J. Koleske2,3, Hava Gil-Henn1 1The Azrieli Faculty of Medicine, Bar-Ilan University, 2Department of Molecular Biophysics and Biochemistry, Yale University, 3Department of Neuroscience, Yale University JoVE 63157 Biology
מדידת דינמיקת בליטה בקצה התא במהלך ההתפשטות באמצעות מיקרוסקופיה של תאים חיים Nikola Lukic*1, Trishna Saha*1, Stefanie Lapetina1, Michal Gendler1, Gilad Lehmann1, Anthony J. Koleske2,3, Hava Gil-Henn1 1The Azrieli Faculty of Medicine, Bar-Ilan University, 2Department of Molecular Biophysics and Biochemistry, Yale University, 3Department of Neuroscience, Yale University JoVE 63157 Biology