Anthony Kossiakoff The Recombinant Antibody Network Biography Publications Institution JoVE Articles Anthony Kossiakoff has not added a biography. If you are Anthony Kossiakoff and would like to personalize this page please email our Author Liaison for assistance. Publications Engineering Synthetic Antibody Binders for Allosteric Inhibition of Prolactin Receptor Signaling Cell Communication and Signaling : CCS. Jan, 2015 | Pubmed ID: 25589173 Applications for an Engineered Protein-G Variant with a PH Controllable Affinity to Antibody Fragments Journal of Immunological Methods. Dec, 2014 | Pubmed ID: 25450256 Probing the Functions of the Paramyxovirus Glycoproteins F and HN with a Panel of Synthetic Antibodies Journal of Virology. Oct, 2014 | Pubmed ID: 25122782 Visualization of Arrestin Recruitment by a G-protein-coupled Receptor Nature. Aug, 2014 | Pubmed ID: 25043026 Human-chromatin-related Protein Interactions Identify a Demethylase Complex Required for Chromosome Segregation Cell Reports. Jul, 2014 | Pubmed ID: 24981860 Cell Biology. New Tricks for an Old Dimer Science (New York, N.Y.). May, 2014 | Pubmed ID: 24833381 Structural Mechanism of Voltage-dependent Gating in an Isolated Voltage-sensing Domain Nature Structural & Molecular Biology. Mar, 2014 | Pubmed ID: 24487958 Structure of Active β-arrestin-1 Bound to a G-protein-coupled Receptor Phosphopeptide Nature. May, 2013 | Pubmed ID: 23604254 Generating Conformation-specific Synthetic Antibodies to Trap Proteins in Selected Functional States Methods (San Diego, Calif.). Mar, 2013 | Pubmed ID: 23280336 Substance P Derivatives As Versatile Tools for Specific Delivery of Various Types of Biomolecular Cargo Bioconjugate Chemistry. Jan, 2012 | Pubmed ID: 22175275 Mechanism of Activation Gating in the Full-length KcsA K+ Channel Proceedings of the National Academy of Sciences of the United States of America. Jul, 2011 | Pubmed ID: 21730186 Allosteric Control of Ligand-binding Affinity Using Engineered Conformation-specific Effector Proteins Nature Structural & Molecular Biology. Apr, 2011 | Pubmed ID: 21378967 A Portable RNA Sequence Whose Recognition by a Synthetic Antibody Facilitates Structural Determination Nature Structural & Molecular Biology. Jan, 2011 | Pubmed ID: 21151117 Characterization of Engineered Actin Binding Proteins That Control Filament Assembly and Structure PloS One. 2010 | Pubmed ID: 21103060 Keeping Signaling in Check Structure (London, England : 1993). Mar, 2010 | Pubmed ID: 20223207 Role of a Salt Bridge in the Model Protein Crambin Explored by Chemical Protein Synthesis: X-ray Structure of a Unique Protein Analogue, [V15A]crambin-alpha-carboxamide Molecular BioSystems. Jul, 2009 | Pubmed ID: 19562114 An Engineered Substance P Variant for Receptor-mediated Delivery of Synthetic Antibodies into Tumor Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2009 | Pubmed ID: 19549879 Racemic Crystallography of Synthetic Protein Enantiomers Used to Determine the X-ray Structure of Plectasin by Direct Methods Protein Science : a Publication of the Protein Society. Jun, 2009 | Pubmed ID: 19472324 Crystal Structure of Full-length KcsA in Its Closed Conformation Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009 | Pubmed ID: 19346472 Principal Determinants Leading to Transition State Formation of a Protein-protein Complex, Orientation Trumps Side-chain Interactions Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009 | Pubmed ID: 19196954 X-ray Structure of Native Scorpion Toxin BmBKTx1 by Racemic Protein Crystallography Using Direct Methods Journal of the American Chemical Society. Feb, 2009 | Pubmed ID: 19133782 Understanding Mechanisms Governing Protein-protein Interactions from Synthetic Binding Interfaces Current Opinion in Structural Biology. Aug, 2008 | Pubmed ID: 18638552 X-ray Structure of Snow Flea Antifreeze Protein Determined by Racemic Crystallization of Synthetic Protein Enantiomers Journal of the American Chemical Society. Jul, 2008 | Pubmed ID: 18598029 Toward Chaperone-assisted Crystallography: Protein Engineering Enhancement of Crystal Packing and X-ray Phasing Capabilities of a Camelid Single-domain Antibody (VHH) Scaffold Protein Science : a Publication of the Protein Society. Jul, 2008 | Pubmed ID: 18445622 The 1.38 A Crystal Structure of DmsD Protein from Salmonella Typhimurium, a Proofreading Chaperone on the Tat Pathway Proteins. May, 2008 | Pubmed ID: 18175314 Synthetic Antibodies for Specific Recognition and Crystallization of Structured RNA Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008 | Pubmed ID: 18162543 Exploring the Capacity of Minimalist Protein Interfaces: Interface Energetics and Affinity Maturation to Picomolar KD of a Single-domain Antibody with a Flat Paratope Journal of Molecular Biology. Nov, 2007 | Pubmed ID: 17888451 High-throughput Generation of Synthetic Antibodies from Highly Functional Minimalist Phage-displayed Libraries Journal of Molecular Biology. Nov, 2007 | Pubmed ID: 17825836 Exploring and Designing Protein Function with Restricted Diversity Current Opinion in Chemical Biology. Jun, 2007 | Pubmed ID: 17500026 Time-controlled Microfluidic Seeding in NL-volume Droplets to Separate Nucleation and Growth Stages of Protein Crystallization Angewandte Chemie (International Ed. in English). Dec, 2006 | Pubmed ID: 17099920 The Role of Protein Dynamics in Increasing Binding Affinity for an Engineered Protein-protein Interaction Established by H/D Exchange Mass Spectrometry Biochemistry. Jul, 2006 | Pubmed ID: 16834322 Comprehensive and Quantitative Mapping of Energy Landscapes for Protein-protein Interactions by Rapid Combinatorial Scanning The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16762925 Structure of Bistramide A-actin Complex at a 1.35 Angstroms Resolution Journal of the American Chemical Society. Mar, 2006 | Pubmed ID: 16551075 Crystal Structure and Site 1 Binding Energetics of Human Placental Lactogen Journal of Molecular Biology. May, 2006 | Pubmed ID: 16546209 Dissecting the Energetics of Protein Alpha-helix C-cap Termination Through Chemical Protein Synthesis Nature Chemical Biology. Mar, 2006 | Pubmed ID: 16446709 The Crystal Structure of Aq_328 from the Hyperthermophilic Bacteria Aquifex Aeolicus Shows an Ancestral Histone Fold Proteins. Jan, 2006 | Pubmed ID: 16287087 Alternative Views of Functional Protein Binding Epitopes Obtained by Combinatorial Shotgun Scanning Mutagenesis Protein Science : a Publication of the Protein Society. Sep, 2005 | Pubmed ID: 16131663 Shotgun Alanine Scanning Shows That Growth Hormone Can Bind Productively to Its Receptor Through a Drastically Minimized Interface The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15857837 Total Chemical Synthesis and X-ray Crystal Structure of a Protein Diastereomer: [D-Gln 35]ubiquitin Angewandte Chemie (International Ed. in English). Jun, 2005 | Pubmed ID: 15834850 Intramolecular Cooperativity in a Protein Binding Site Assessed by Combinatorial Shotgun Scanning Mutagenesis Journal of Molecular Biology. Apr, 2005 | Pubmed ID: 15755445 The Crystal Structure of a Quercetin 2,3-dioxygenase from Bacillus Subtilis Suggests Modulation of Enzyme Activity by a Change in the Metal Ion at the Active Site(s) Biochemistry. Jan, 2005 | Pubmed ID: 15628860 The High- and Low-affinity Receptor Binding Sites of Growth Hormone Are Allosterically Coupled Proceedings of the National Academy of Sciences of the United States of America. Dec, 2004 | Pubmed ID: 15563602 The Structural Basis for Biological Signaling, Regulation, and Specificity in the Growth Hormone-prolactin System of Hormones and Receptors Advances in Protein Chemistry. 2004 | Pubmed ID: 15500861 Dissecting the Binding Energy Epitope of a High-affinity Variant of Human Growth Hormone: Cooperative and Additive Effects from Combining Mutations from Independently Selected Phage Display Mutagenesis Libraries Biochemistry. May, 2004 | Pubmed ID: 15147191 The Functional Binding Epitope of a High Affinity Variant of Human Growth Hormone Mapped by Shotgun Alanine-scanning Mutagenesis: Insights into the Mechanisms Responsible for Improved Affinity Journal of Molecular Biology. Sep, 2003 | Pubmed ID: 12946357 Site2 Binding Energetics of the Regulatory Step of Growth Hormone-induced Receptor Homodimerization Protein Science : a Publication of the Protein Society. Sep, 2003 | Pubmed ID: 12930995 The First Semi-synthetic Serine Protease Made by Native Chemical Ligation Protein Expression and Purification. Jun, 2003 | Pubmed ID: 12767808 Determination of the Energetics Governing the Regulatory Step in Growth Hormone-induced Receptor Homodimerization Proceedings of the National Academy of Sciences of the United States of America. Feb, 2003 | Pubmed ID: 12552121 Functional Promiscuity of Squirrel Monkey Growth Hormone Receptor Toward Both Primate and Nonprimate Growth Hormones Molecular Biology and Evolution. Jul, 2002 | Pubmed ID: 12082127 Structure of a Phage Display-derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of Its Receptor: Evidence for Strong Structural Coupling Between Receptor Binding Sites Journal of Molecular Biology. Feb, 2002 | Pubmed ID: 11851338 Skalbar hög genomströmning Urval Från faguppvisade Syntetiska Antibody bibliotek Shane Miersch1,2, Zhijian Li1,2, Rachel Hanna1,2, Megan E. McLaughlin1,2, Michael Hornsby1,3, Tet Matsuguchi1,3, Marcin Paduch1,4, Annika Sääf1,4, Jim Wells1,3, Shohei Koide1,4, Anthony Kossiakoff1,4, Sachdev S. Sidhu1,2 1The Recombinant Antibody Network, 2The Banting and Best Department of Medical Research, University of Toronto, 3Antibiome Center, University of California, San Francisco at Mission Bay, 4Department of Biochemistry and Molecular Biology, The University of Chicago JoVE 51492 Immunology and Infection
Skalbar hög genomströmning Urval Från faguppvisade Syntetiska Antibody bibliotek Shane Miersch1,2, Zhijian Li1,2, Rachel Hanna1,2, Megan E. McLaughlin1,2, Michael Hornsby1,3, Tet Matsuguchi1,3, Marcin Paduch1,4, Annika Sääf1,4, Jim Wells1,3, Shohei Koide1,4, Anthony Kossiakoff1,4, Sachdev S. Sidhu1,2 1The Recombinant Antibody Network, 2The Banting and Best Department of Medical Research, University of Toronto, 3Antibiome Center, University of California, San Francisco at Mission Bay, 4Department of Biochemistry and Molecular Biology, The University of Chicago JoVE 51492 Immunology and Infection