Ashley M. Buckle Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute Monash University Biography Publications Institution JoVE Articles Ashley M. Buckle has not added a biography. If you are Ashley M. Buckle and would like to personalize this page please email our Author Liaison for assistance. Publications High Avidity Drives the Interaction Between the Streptococcal C1 Phage Endolysin, PlyC, with the Cell Surface Carbohydrates of Group A Streptococcus Molecular Microbiology. Mar, 2021 | Pubmed ID: 33756056 A Comprehensive Phylogenetic Analysis of the Serpin Superfamily Molecular Biology and Evolution. Jun, 2021 | Pubmed ID: 33744972 Mutational and Biophysical Robustness in a Pre-stabilized Monobody The Journal of Biological Chemistry. Feb, 2021 | Pubmed ID: 33617878 Impact of HLA-DR Antigen Binding Cleft Rigidity on T Cell Recognition International Journal of Molecular Sciences. Sep, 2020 | Pubmed ID: 32992915 Conformational Diversity Facilitates Antibody Mutation Trajectories and Discrimination Between Foreign and Self-antigens Proceedings of the National Academy of Sciences of the United States of America. 09, 2020 | Pubmed ID: 32855302 Intrinsic Limitations in Mainstream Methods of Identifying Network Motifs in Biology BMC Bioinformatics. Apr, 2020 | Pubmed ID: 32349657 Development and Differentiation in Monobodies Based on the Fibronectin Type 3 Domain Cells. 03, 2020 | Pubmed ID: 32143310 Structural Studies of Thyroid Peroxidase Show the Monomer Interacting With Autoantibodies in Thyroid Autoimmune Disease Endocrinology. 02, 2020 | Pubmed ID: 32022847 Strategies for Increasing Protein Stability Methods in Molecular Biology (Clifton, N.J.). 2020 | Pubmed ID: 31612442 Ribosome Evolution and Structural Capacitance Frontiers in Molecular Biosciences. 2019 | Pubmed ID: 31803754 Denisovan, Modern Human and Mouse TNFAIP3 Alleles Tune A20 Phosphorylation and Immunity Nature Immunology. 10, 2019 | Pubmed ID: 31534238 Crystal Structure of the Inhibitor-free Form of the Serine Protease Kallikrein-4 Acta Crystallographica. Section F, Structural Biology Communications. Aug, 2019 | Pubmed ID: 31397325 The Role of Conformational Dynamics in Abacavir-Induced Hypersensitivity Syndrome Scientific Reports. 07, 2019 | Pubmed ID: 31324847 Wavelength-Dependent Fluorescent Immunosensors Via Incorporation of Polarity Indicators Near the Binding Interface of Antibody Fragments Analytical Chemistry. 06, 2019 | Pubmed ID: 31117403 KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors Biochemistry. 05, 2019 | Pubmed ID: 31058493 Protein Engineering: the Potential of Remote Mutations Biochemical Society Transactions. 04, 2019 | Pubmed ID: 30902926 Reactive Centre Loop Dynamics and Serpin Specificity Scientific Reports. 03, 2019 | Pubmed ID: 30846766 Potent, Multi-target Serine Protease Inhibition Achieved by a Simplified β-sheet Motif PloS One. 2019 | Pubmed ID: 30668585 Prostate Cancer Risk-Associated Single-Nucleotide Polymorphism Affects Prostate-Specific Antigen Glycosylation and Its Function Clinical Chemistry. 01, 2019 | Pubmed ID: 30538125 Integrating Experiment and Theory to Understand TCR-pMHC Dynamics Frontiers in Immunology. 2018 | Pubmed ID: 30581442 Thyroid Peroxidase As an Autoantigen in Hashimoto's Disease: Structure, Function, and Antigenicity Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. Dec, 2018 | Pubmed ID: 30360003 Mapping the Pathway and Dynamics of Bestatin Inhibition of the Plasmodium Falciparum M1 Aminopeptidase PfA-M1 ChemMedChem. 12, 2018 | Pubmed ID: 30318749 Catalytic Diversity and Cell Wall Binding Repeats in the Phage-encoded Endolysins Molecular Microbiology. 12, 2018 | Pubmed ID: 30230642 Structural Capacitance in Protein Evolution and Human Diseases Journal of Molecular Biology. 09, 2018 | Pubmed ID: 30111491 Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target Structure (London, England : 1993). 07, 2018 | Pubmed ID: 29804823 Previously Hidden Dynamics at the TCR-Peptide-MHC Interface Revealed Journal of Immunology (Baltimore, Md. : 1950). 06, 2018 | Pubmed ID: 29728507 Recognition by Host Nuclear Transport Proteins Drives Disorder-to-order Transition in Hendra Virus V Scientific Reports. 01, 2018 | Pubmed ID: 29321677 Laboratory Evolution of Protein Conformational Dynamics Current Opinion in Structural Biology. 06, 2018 | Pubmed ID: 29120734 Generation of AMBER Force Field Parameters for Zinc Centres of M1 and M17 Family Aminopeptidases Journal of Biomolecular Structure & Dynamics. Aug, 2018 | Pubmed ID: 28782419 REFOLDdb: a New and Sustainable Gateway to Experimental Protocols for Protein Refolding BMC Structural Biology. 04, 2017 | Pubmed ID: 28438161 The Pu.1 Target Gene Zbtb11 Regulates Neutrophil Development Through Its Integrase-like HHCC Zinc Finger Nature Communications. 04, 2017 | Pubmed ID: 28382966 Structural Reconstruction of Protein Ancestry Proceedings of the National Academy of Sciences of the United States of America. 04, 2017 | Pubmed ID: 28356519 Direct and Indirect Mechanisms of KLK4 Inhibition Revealed by Structure and Dynamics Scientific Reports. 10, 2016 | Pubmed ID: 27767076 Smoothing a Rugged Protein Folding Landscape by Sequence-based Redesign Scientific Reports. Sep, 2016 | Pubmed ID: 27667094 The Role of Protein Dynamics in the Evolution of New Enzyme Function Nature Chemical Biology. Nov, 2016 | Pubmed ID: 27618189 Circumventing the Stability-function Trade-off in an Engineered FN3 Domain Protein Engineering, Design & Selection : PEDS. Nov, 2016 | Pubmed ID: 27578887 Consensus Protein Design Protein Engineering, Design & Selection : PEDS. 07, 2016 | Pubmed ID: 27274091 KinetochoreDB: a Comprehensive Online Resource for the Kinetochore and Its Related Proteins Database : the Journal of Biological Databases and Curation. 2016 | Pubmed ID: 26989151 PolyQ 2.0: an Improved Version of PolyQ, a Database of Human Polyglutamine Proteins Database : the Journal of Biological Databases and Curation. 2016 | Pubmed ID: 26980520 A Colostrum Trypsin Inhibitor Gene Expressed in the Cape Fur Seal Mammary Gland During Lactation Gene. Mar, 2016 | Pubmed ID: 26639991 Critical Evaluation of in Silico Methods for Prediction of Coiled-coil Domains in Proteins Briefings in Bioinformatics. Mar, 2016 | Pubmed ID: 26177815 Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity PloS One. 2015 | Pubmed ID: 26623656 Dynamic Motion and Communication in the Streptococcal C1 Phage Lysin, PlyC PloS One. 2015 | Pubmed ID: 26470022 Solution Structure of a Soluble Fragment Derived from a Membrane Protein by Shotgun Proteolysis Protein Engineering, Design & Selection : PEDS. Oct, 2015 | Pubmed ID: 25877662 Structural and Dynamic Properties That Govern the Stability of an Engineered Fibronectin Type III Domain Protein Engineering, Design & Selection : PEDS. Mar, 2015 | Pubmed ID: 25691761 Understanding the Structural Dynamics of TCR-pMHC Complex Interactions Trends in Immunology. 12, 2014 | Pubmed ID: 25466310 Operation of the Australian Store.Synchrotron for Macromolecular Crystallography Acta Crystallographica. Section D, Biological Crystallography. Oct, 2014 | Pubmed ID: 25286837 Oxidation of an Exposed Methionine Instigates the Aggregation of Glyceraldehyde-3-Phosphate Dehydrogenase The Journal of Biological Chemistry. Aug, 2014 | Pubmed ID: 25086035 Cofactor-dependent Conformational Heterogeneity of GAD65 and Its Role in Autoimmunity and Neurotransmitter Homeostasis Proceedings of the National Academy of Sciences of the United States of America. Jun, 2014 | Pubmed ID: 24927554 The α-importome of Mammalian Germ Cell Maturation Provides Novel Insights for Importin Biology FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2014 | Pubmed ID: 24790034 PLP-dependent Enzymes BioMed Research International. 2014 | Pubmed ID: 24527459 A Redundant Role of Human Thyroid Peroxidase Propeptide for Cellular, Enzymatic, and Immunological Activity Thyroid : Official Journal of the American Thyroid Association. Feb, 2014 | Pubmed ID: 23668778 Interactive Visualization Tools for the Structural Biologist Journal of Applied Crystallography. Oct, 2013 | Pubmed ID: 24068844 Molecular Determinants of the Substrate Specificity of the Complement-initiating Protease, C1r The Journal of Biological Chemistry. May, 2013 | Pubmed ID: 23589288 Structural Characterization of the Mechanism Through Which Human Glutamic Acid Decarboxylase Auto-activates Bioscience Reports. Jan, 2013 | Pubmed ID: 23126365 X-ray Crystal Structure of the Streptococcal Specific Phage Lysin PlyC Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22807482 Crystal, Solution and in Silico Structural Studies of Dihydrodipicolinate Synthase from the Common Grapevine PloS One. 2012 | Pubmed ID: 22761676 Conformational Properties of the Disease-causing Z Variant of α1-antitrypsin Revealed by Theory and Experiment Biophysical Journal. Jun, 2012 | Pubmed ID: 22735536 Hybrid Approaches to Molecular Simulation Current Opinion in Structural Biology. Jun, 2012 | Pubmed ID: 22633678 Epitope Flexibility and Dynamic Footprint Revealed by Molecular Dynamics of a PMHC-TCR Complex PLoS Computational Biology. 2012 | Pubmed ID: 22412359 Membrane Proteins of Pseudoalteromonas Tunicata During the Transition from Planktonic to Extracellular Matrix-adherent State Environmental Microbiology Reports. Jun, 2011 | Pubmed ID: 23761287 Recombinant Protein Quality Evaluation: Proposal for a Minimal Information Standard Standards in Genomic Sciences. Nov, 2011 | Pubmed ID: 22180821 Computational Methods for Studying Serpin Conformational Change and Structural Plasticity Methods in Enzymology. 2011 | Pubmed ID: 22078540 The Rate of PolyQ-mediated Aggregation is Dramatically Affected by the Number and Location of Surrounding Domains Journal of Molecular Biology. Nov, 2011 | Pubmed ID: 21945530 Refolding Your Protein with a Little Help from REFOLD Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21713630 Mastering the Canonical Loop of Serine Protease Inhibitors: Enhancing Potency by Optimising the Internal Hydrogen Bond Network PloS One. Apr, 2011 | Pubmed ID: 21556330 Crystallographic and Molecular Dynamics Analysis of Loop Motions Unmasking the Peptidoglycan-binding Site in Stator Protein MotB of Flagellar Motor PloS One. Apr, 2011 | Pubmed ID: 21533052 An Analysis of the Cross-reactivity of Autoantibodies to GAD65 and GAD67 in Diabetes PloS One. Apr, 2011 | Pubmed ID: 21494613 PolyQ: a Database Describing the Sequence and Domain Context of Polyglutamine Repeats in Proteins Nucleic Acids Research. Jan, 2011 | Pubmed ID: 21059684 Characterisation of Peptide Microarrays for Studying Antibody-antigen Binding Using Surface Plasmon Resonance Imagery PloS One. Aug, 2010 | Pubmed ID: 20730101 EGM: Encapsulated Gene-by-gene Matching to Identify Gene Orthologs and Homologous Segments in Genomes Bioinformatics (Oxford, England). Sep, 2010 | Pubmed ID: 20581400 MrGrid: a Portable Grid Based Molecular Replacement Pipeline PloS One. Apr, 2010 | Pubmed ID: 20386612 MUSTANG-MR Structural Sieving Server: Applications in Protein Structural Analysis and Crystallography PloS One. Apr, 2010 | Pubmed ID: 20386610 The X-ray Crystal Structure of Escherichia Coli Succinic Semialdehyde Dehydrogenase; Structural Insights into NADP+/enzyme Interactions PloS One. Feb, 2010 | Pubmed ID: 20174634 Structure of the Plasmodium Falciparum M17 Aminopeptidase and Significance for the Design of Drugs Targeting the Neutral Exopeptidases Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20133789 Structural Biology of the GAD Autoantigen Autoimmunity Reviews. Jan, 2010 | Pubmed ID: 19465164 Structural Determinants of GAD Antigenicity Molecular Immunology. Dec, 2009 | Pubmed ID: 19783309 Prodepth: Predict Residue Depth by Support Vector Regression Approach from Protein Sequences Only PloS One. Sep, 2009 | Pubmed ID: 19759917 Structure of Granzyme C Reveals an Unusual Mechanism of Protease Autoinhibition Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009 | Pubmed ID: 19299505 Structural Basis for the Inhibition of the Essential Plasmodium Falciparum M1 Neutral Aminopeptidase Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009 | Pubmed ID: 19196988 Federated Repositories of X-ray Diffraction Images Acta Crystallographica. Section D, Biological Crystallography. Jul, 2008 | Pubmed ID: 18566516 The MACPF/CDC Family of Pore-forming Toxins Cellular Microbiology. Sep, 2008 | Pubmed ID: 18564372 A Structural Basis for Loop C-sheet Polymerization in Serpins Journal of Molecular Biology. Mar, 2008 | Pubmed ID: 18234218 COOH-terminal Clustering of Autoantibody and T-cell Determinants on the Structure of GAD65 Provide Insights into the Molecular Basis of Autoreactivity Diabetes. May, 2008 | Pubmed ID: 18184926 X-ray Crystal Structure of the Fibrinolysis Inhibitor Alpha2-antiplasmin Blood. Feb, 2008 | Pubmed ID: 18063751 A Common Fold Mediates Vertebrate Defense and Bacterial Attack Science (New York, N.Y.). Sep, 2007 | Pubmed ID: 17717151 The N Terminus of the Serpin, Tengpin, Functions to Trap the Metastable Native State EMBO Reports. Jul, 2007 | Pubmed ID: 17557112 GABA Production by Glutamic Acid Decarboxylase is Regulated by a Dynamic Catalytic Loop Nature Structural & Molecular Biology. Apr, 2007 | Pubmed ID: 17384644 The 1.6 A Crystal Structure of the Catalytic Domain of PlyB, a Bacteriophage Lysin Active Against Bacillus Anthracis Journal of Molecular Biology. Feb, 2007 | Pubmed ID: 17182056 Protein Folding Database (PFD 2.0): an Online Environment for the International Foldeomics Consortium Nucleic Acids Research. Jan, 2007 | Pubmed ID: 17170010 X-ray Crystal Structure of MENT: Evidence for Functional Loop-sheet Polymers in Chromatin Condensation The EMBO Journal. Jul, 2006 | Pubmed ID: 16810322 An Overview of the Serpin Superfamily Genome Biology. 2006 | Pubmed ID: 16737556 The REFOLD Database: a Tool for the Optimization of Protein Expression and Refolding Nucleic Acids Research. Jan, 2006 | Pubmed ID: 16381847 Managing and Mining Protein Crystallization Data Proteins. Jan, 2006 | Pubmed ID: 16287081 REFOLD: an Analytical Database of Protein Refolding Methods Protein Expression and Purification. Mar, 2006 | Pubmed ID: 16150607 T Cell Receptor Recognition of a 'super-bulged' Major Histocompatibility Complex Class I-bound Peptide Nature Immunology. Nov, 2005 | Pubmed ID: 16186824 Control of the Coagulation System by Serpins. Getting by with a Little Help from Glycosaminoglycans The FEBS Journal. Oct, 2005 | Pubmed ID: 16176258 The 2.1A Crystal Structure of the Far-red Fluorescent Protein HcRed: Inherent Conformational Flexibility of the Chromophore Journal of Molecular Biology. May, 2005 | Pubmed ID: 15876379 The High Resolution Crystal Structure of the Human Tumor Suppressor Maspin Reveals a Novel Conformational Switch in the G-helix The Journal of Biological Chemistry. Jun, 2005 | Pubmed ID: 15760906 PFD: a Database for the Investigation of Protein Folding Kinetics and Stability Nucleic Acids Research. Jan, 2005 | Pubmed ID: 15608196 CLIMS: Crystallography Laboratory Information Management System Acta Crystallographica. Section D, Biological Crystallography. Sep, 2004 | Pubmed ID: 15333956 Haemophilus Influenzae'ye Solunum İmmün Yanıtlarının Değerlendirilmesi Lovisa Dousha1,2, Roleen Sharma1,2, Steven Lim2,3, James Ngui2,4, Ashley M. Buckle5, Paul T. King1,2 1Monash Lung and Sleep, Monash Medical Centre, 2Monash University Department of Medicine, Monash Medical Centre, 3Flow Cytometry Science Technology Platform, Francis Crick Institute, 4Clinical Immunology, Monash Medical Centre, 5Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University JoVE 62572 Immunology and Infection
Haemophilus Influenzae'ye Solunum İmmün Yanıtlarının Değerlendirilmesi Lovisa Dousha1,2, Roleen Sharma1,2, Steven Lim2,3, James Ngui2,4, Ashley M. Buckle5, Paul T. King1,2 1Monash Lung and Sleep, Monash Medical Centre, 2Monash University Department of Medicine, Monash Medical Centre, 3Flow Cytometry Science Technology Platform, Francis Crick Institute, 4Clinical Immunology, Monash Medical Centre, 5Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University JoVE 62572 Immunology and Infection