Asrar B. Malik Department of Pharmacology, University of Illinois College of Medicine University of Illinois at Chicago Biography Publications Institution JoVE Articles Asrar B. Malik has not added a biography. If you are Asrar B. Malik and would like to personalize this page please email our Author Liaison for assistance. Publications Microfluidic Platform Generates Oxygen Landscapes for Localized Hypoxic Activation Lab on a Chip. Oct, 2014 | Pubmed ID: 25315003 Reprogramming Fibroblasts to Endothelial Cells: Converted or Born Again? Circulation. Sep, 2014 | Pubmed ID: 25186942 KIF13B Regulates Angiogenesis Through Golgi to Plasma Membrane Trafficking of VEGFR2 Journal of Cell Science. Oct, 2014 | Pubmed ID: 25128562 Cooperative Signaling Via Transcription Factors NF-κB and AP1/c-Fos Mediates Endothelial Cell STIM1 Expression and Hyperpermeability in Response to Endotoxin The Journal of Biological Chemistry. Aug, 2014 | Pubmed ID: 25016017 Differential Role for P120-catenin in Regulation of TLR4 Signaling in Macrophages Journal of Immunology (Baltimore, Md. : 1950). Aug, 2014 | Pubmed ID: 25015829 Combinatorial Therapy with Acetylation and Methylation Modifiers Attenuates Lung Vascular Hyperpermeability in Endotoxemia-induced Mouse Inflammatory Lung Injury The American Journal of Pathology. Aug, 2014 | Pubmed ID: 24929240 Regulating the Regulator of ROS Production Cell Research. Aug, 2014 | Pubmed ID: 24839902 Endothelial Progenitor Cells and Vascular Repair Current Opinion in Hematology. May, 2014 | Pubmed ID: 24637956 Evidence of a Common Mechanism of Disassembly of Adherens Junctions Through Gα13 Targeting of VE-cadherin The Journal of Experimental Medicine. Mar, 2014 | Pubmed ID: 24590762 Therapeutic Administration of the Chemokine CXCL1/KC Abrogates Autoimmune Inflammatory Heart Disease PloS One. 2014 | Pubmed ID: 24586934 Prevention of Vascular Inflammation by Nanoparticle Targeting of Adherent Neutrophils Nature Nanotechnology. Mar, 2014 | Pubmed ID: 24561355 Genetic Variation is the Major Determinant of Individual Differences in Leukocyte Endothelial Adhesion PloS One. 2014 | Pubmed ID: 24520339 The Transcription Factor DREAM Represses the Deubiquitinase A20 and Mediates Inflammation Nature Immunology. Mar, 2014 | Pubmed ID: 24487321 Cooperative Interaction of Trp Melastatin Channel Transient Receptor Potential (TRPM2) with Its Splice Variant TRPM2 Short Variant is Essential for Endothelial Cell Apoptosis Circulation Research. Jan, 2014 | Pubmed ID: 24337049 Reactive Oxygen Species in Inflammation and Tissue Injury Antioxidants & Redox Signaling. Mar, 2014 | Pubmed ID: 23991888 Flk1+ and VE-cadherin+ Endothelial Cells Derived from IPSCs Recapitulates Vascular Development During Differentiation and Display Similar Angiogenic Potential As ESC-derived Cells PloS One. 2013 | Pubmed ID: 24386480 Caveolin-1 Tyr14 Phosphorylation Induces Interaction with TLR4 in Endothelial Cells and Mediates MyD88-dependent Signaling and Sepsis-induced Lung Inflammation Journal of Immunology (Baltimore, Md. : 1950). Dec, 2013 | Pubmed ID: 24244013 A Critical Role for Lyn Kinase in Strengthening Endothelial Integrity and Barrier Function Blood. Dec, 2013 | Pubmed ID: 24108461 Transcriptional Regulation of Endothelial Cell and Vascular Development Circulation Research. May, 2013 | Pubmed ID: 23661712 Store-operated Ca2+ Entry (SOCE) Induced by Protease-activated Receptor-1 Mediates STIM1 Protein Phosphorylation to Inhibit SOCE in Endothelial Cells Through AMP-activated Protein Kinase and P38β Mitogen-activated Protein Kinase The Journal of Biological Chemistry. Jun, 2013 | Pubmed ID: 23625915 Bioluminescent Detection of Peroxynitrite with a Boronic Acid-caged Luciferin Free Radical Biology & Medicine. Aug, 2013 | Pubmed ID: 23474271 Activation of NLRP3 Inflammasome in Alveolar Macrophages Contributes to Mechanical Stretch-induced Lung Inflammation and Injury Journal of Immunology (Baltimore, Md. : 1950). Apr, 2013 | Pubmed ID: 23436933 Nanoparticles Squeezing Across the Blood-endothelial Barrier Via Caveolae Therapeutic Delivery. Feb, 2013 | Pubmed ID: 23343150 Cytoskeletal Dynamics and Lung Fluid Balance Comprehensive Physiology. Jan, 2012 | Pubmed ID: 23728978 VE-Cadherin Signaling Induces EB3 Phosphorylation to Suppress Microtubule Growth and Assemble Adherens Junctions Molecular Cell. Nov, 2012 | Pubmed ID: 23159740 TLR4 Activation of TRPC6-dependent Calcium Signaling Mediates Endotoxin-induced Lung Vascular Permeability and Inflammation The Journal of Experimental Medicine. Oct, 2012 | Pubmed ID: 23045603 A Critical Role for P-Rex1 in Endothelial Junction Disruption and Vascular Hyper-Permeability Circulation Research. Sep, 2012 | Pubmed ID: 22965143 ICAM-1-activated Src and ENOS Signaling Increase Endothelial Cell Surface PECAM-1 Adhesivity and Neutrophil Transmigration Blood. Aug, 2012 | Pubmed ID: 22806890 PKCα Activation of P120-catenin Serine 879 Phospho-switch Disassembles VE-cadherin Junctions and Disrupts Vascular Integrity Circulation Research. Aug, 2012 | Pubmed ID: 22798526 Bidirectional Regulation of Neutrophil Migration by Mitogen-activated Protein Kinases Nature Immunology. May, 2012 | Pubmed ID: 22447027 Sphingosine Kinase 1 Mediation of Expression of the Anaphylatoxin Receptor C5L2 Dampens the Inflammatory Response to Endotoxin PloS One. 2012 | Pubmed ID: 22355325 Nitric Oxide-dependent Src Activation and Resultant Caveolin-1 Phosphorylation Promote ENOS/caveolin-1 Binding and ENOS Inhibition Molecular Biology of the Cell. Apr, 2012 | Pubmed ID: 22323292 The Ca(2+) Sensor Stromal Interaction Molecule 1 (STIM1) is Necessary and Sufficient for the Store-operated Ca(2+) Entry Function of Transient Receptor Potential Canonical (TRPC) 1 and 4 Channels in Endothelial Cells Molecular Pharmacology. Apr, 2012 | Pubmed ID: 22210847 The Redox-sensitive Cation Channel TRPM2 Modulates Phagocyte ROS Production and Inflammation Nature Immunology. Jan, 2012 | Pubmed ID: 22101731 Role of Endothelial Injury in Disease Mechanisms and Contribution of Progenitor Cells in Mediating Endothelial Repair Immunobiology. May, 2012 | Pubmed ID: 21513999 Permeability of Endothelial Barrier: Cell Culture and in Vivo Models Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21874463 Improvement of Cardiac Function in Mouse Myocardial Infarction After Transplantation of Epigenetically-modified Bone Marrow Progenitor Cells PloS One. 2011 | Pubmed ID: 21799893 Delivery of Nanoparticle: Complexed Drugs Across the Vascular Endothelial Barrier Via Caveolae IUBMB Life. Aug, 2011 | Pubmed ID: 21766412 FoxM1 Mediates the Progenitor Function of Type II Epithelial Cells in Repairing Alveolar Injury Induced by Pseudomonas Aeruginosa The Journal of Experimental Medicine. Jul, 2011 | Pubmed ID: 21708928 Caveolin-1-eNOS Signaling Promotes P190RhoGAP-A Nitration and Endothelial Permeability The Journal of Cell Biology. May, 2011 | Pubmed ID: 21624953 Src Phosphorylation of Endothelial Cell Surface Intercellular Adhesion Molecule-1 Mediates Neutrophil Adhesion and Contributes to the Mechanism of Lung Inflammation Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2011 | Pubmed ID: 21474822 Innate Immune Function of the Adherens Junction Protein P120-catenin in Endothelial Response to Endotoxin Journal of Immunology (Baltimore, Md. : 1950). Mar, 2011 | Pubmed ID: 21278343 Interaction of a Specific Population of Human Embryonic Stem Cell-derived Progenitor Cells with CD11b+ Cells Ameliorates Sepsis-induced Lung Inflammatory Injury The American Journal of Pathology. Jan, 2011 | Pubmed ID: 21224068 Regulation of Dynamin-2 Assembly-disassembly and Function Through the SH3A Domain of Intersectin-1s Journal of Cellular and Molecular Medicine. Nov, 2011 | Pubmed ID: 21129155 NANOG Induction of Fetal Liver Kinase-1 (FLK1) Transcription Regulates Endothelial Cell Proliferation and Angiogenesis Blood. Feb, 2011 | Pubmed ID: 21119109 Kruppel-like Factor-4 Transcriptionally Regulates VE-cadherin Expression and Endothelial Barrier Function Circulation Research. Oct, 2010 | Pubmed ID: 20724706 FoxM1 Regulates Re-annealing of Endothelial Adherens Junctions Through Transcriptional Control of Beta-catenin Expression The Journal of Experimental Medicine. Aug, 2010 | Pubmed ID: 20660612 Role of Protein Kinase Czeta in Thrombin-induced RhoA Activation and Inter-endothelial Gap Formation of Human Dermal Microvessel Endothelial Cell Monolayers Microvascular Research. Sep, 2010 | Pubmed ID: 20417648 Caveolin-1 Deficiency Dampens Toll-like Receptor 4 Signaling Through ENOS Activation The American Journal of Pathology. May, 2010 | Pubmed ID: 20304961 A Novel Function of Sphingosine Kinase 1 Suppression of JNK Activity in Preventing Inflammation and Injury The Journal of Biological Chemistry. May, 2010 | Pubmed ID: 20299461 TRPM2 Channel Regulates Endothelial Barrier Function Advances in Experimental Medicine and Biology. 2010 | Pubmed ID: 20204729 Regulation of Endothelial Permeability Via Paracellular and Transcellular Transport Pathways Annual Review of Physiology. 2010 | Pubmed ID: 20148685 Lipid Phosphate Phosphatase 3 Stabilization of Beta-catenin Induces Endothelial Cell Migration and Formation of Branching Point Structures Molecular and Cellular Biology. Apr, 2010 | Pubmed ID: 20123964 TRP Channels and the Control of Vascular Function Current Opinion in Pharmacology. Apr, 2010 | Pubmed ID: 20060363 Ca2+ Influx Via TRPC Channels Induces NF-kappaB-dependent A20 Expression to Prevent Thrombin-induced Apoptosis in Endothelial Cells American Journal of Physiology. Cell Physiology. Mar, 2010 | Pubmed ID: 20032510 Requisite Role of the Cholinergic Alpha7 Nicotinic Acetylcholine Receptor Pathway in Suppressing Gram-negative Sepsis-induced Acute Lung Inflammatory Injury Journal of Immunology (Baltimore, Md. : 1950). Jan, 2010 | Pubmed ID: 19949071 Bone Marrow-derived Progenitor Cells Prevent Thrombin-induced Increase in Lung Vascular Permeability American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2010 | Pubmed ID: 19880506 Toll-like Receptor 4 Mediates Neutrophil Sequestration and Lung Injury Induced by Endotoxin and Hyperinflation Critical Care Medicine. Jan, 2010 | Pubmed ID: 19789446 A Novel Insight into the Mechanism of Pulmonary Hypertension Involving Caveolin-1 Deficiency and Endothelial Nitric Oxide Synthase Activation Trends in Cardiovascular Medicine. Oct, 2009 | Pubmed ID: 20382348 Size and Dynamics of Caveolae Studied Using Nanoparticles in Living Endothelial Cells ACS Nano. Dec, 2009 | Pubmed ID: 19919048 Requirement of Alpha(4)beta(1) and Alpha(5)beta(1) Integrin Expression in Bone-marrow-derived Progenitor Cells in Preventing Endotoxin-induced Lung Vascular Injury and Edema in Mice Stem Cells (Dayton, Ohio). Dec, 2009 | Pubmed ID: 19839056 A Non-redundant Role for MKP5 in Limiting ROS Production and Preventing LPS-induced Vascular Injury The EMBO Journal. Oct, 2009 | Pubmed ID: 19696743 Bone Marrow Progenitor Cells Induce Endothelial Adherens Junction Integrity by Sphingosine-1-phosphate-mediated Rac1 and Cdc42 Signaling Circulation Research. Sep, 2009 | Pubmed ID: 19696411 LIM Kinase 1 Promotes Endothelial Barrier Disruption and Neutrophil Infiltration in Mouse Lungs Circulation Research. Sep, 2009 | Pubmed ID: 19679840 Intersectin-2L Regulates Caveola Endocytosis Secondary to Cdc42-mediated Actin Polymerization The Journal of Biological Chemistry. Sep, 2009 | Pubmed ID: 19622753 Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation Via TLR4/MyD88 and the CGMP-dependent Protein Kinase Pathway Journal of Immunology (Baltimore, Md. : 1950). Jun, 2009 | Pubmed ID: 19494325 Persistent ENOS Activation Secondary to Caveolin-1 Deficiency Induces Pulmonary Hypertension in Mice and Humans Through PKG Nitration The Journal of Clinical Investigation. Jul, 2009 | Pubmed ID: 19487814 NF-kappaB Regulates Thrombin-induced ICAM-1 Gene Expression in Cooperation with NFAT by Binding to the Intronic NF-kappaB Site in the ICAM-1 Gene Physiological Genomics. Jun, 2009 | Pubmed ID: 19351910 Role of H(2)O(2)-activated TRPM2 Calcium Channel in Oxidant-induced Endothelial Injury Thrombosis and Haemostasis. Apr, 2009 | Pubmed ID: 19350103 Tiam1 and Rac1 Are Required for Platelet-activating Factor-induced Endothelial Junctional Disassembly and Increase in Vascular Permeability The Journal of Biological Chemistry. Feb, 2009 | Pubmed ID: 19095647 Caveolin-1 Scaffold Domain Interacts with TRPC1 and IP3R3 to Regulate Ca2+ Store Release-induced Ca2+ Entry in Endothelial Cells American Journal of Physiology. Cell Physiology. Mar, 2009 | Pubmed ID: 19052258 Ca2+ Entry Via TRPC Channels is Necessary for Thrombin-induced NF-kappaB Activation in Endothelial Cells Through AMP-activated Protein Kinase and Protein Kinase Cdelta The Journal of Biological Chemistry. Jan, 2009 | Pubmed ID: 18990707 NADPH Oxidase-dependent Signaling in Endothelial Cells: Role in Physiology and Pathophysiology Antioxidants & Redox Signaling. Apr, 2009 | Pubmed ID: 18783313 Activation of Sphingosine Kinase-1 Reverses the Increase in Lung Vascular Permeability Through Sphingosine-1-phosphate Receptor Signaling in Endothelial Cells Circulation Research. Nov, 2008 | Pubmed ID: 18849324 FGF Signaling Preserves the Integrity of Endothelial Adherens Junctions Developmental Cell. Sep, 2008 | Pubmed ID: 18804429 Nonmuscle Myosin Light-chain Kinase Mediates Neutrophil Transmigration in Sepsis-induced Lung Inflammation by Activating Beta2 Integrins Nature Immunology. Aug, 2008 | Pubmed ID: 18587400 Critical Role of Cdc42 in Mediating Endothelial Barrier Protection in Vivo American Journal of Physiology. Lung Cellular and Molecular Physiology. Aug, 2008 | Pubmed ID: 18515405 Intercellular Adhesion Molecule-1-dependent Neutrophil Adhesion to Endothelial Cells Induces Caveolae-mediated Pulmonary Vascular Hyperpermeability Circulation Research. Jun, 2008 | Pubmed ID: 18511851 Augmented Inducible Nitric Oxide Synthase Expression and Increased NO Production Reduce Sepsis-induced Lung Injury and Mortality in Myeloperoxidase-null Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2008 | Pubmed ID: 18424617 Regulation of Endothelial Junctional Permeability Annals of the New York Academy of Sciences. Mar, 2008 | Pubmed ID: 18375586 Increased Pulmonary Vascular Resistance and Defective Pulmonary Artery Filling in Caveolin-1-/- Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2008 | Pubmed ID: 18192592 Role of NF-kappaB-dependent Caveolin-1 Expression in the Mechanism of Increased Endothelial Permeability Induced by Lipopolysaccharide The Journal of Biological Chemistry. Feb, 2008 | Pubmed ID: 18077459 Role of TRPM2 Channel in Mediating H2O2-induced Ca2+ Entry and Endothelial Hyperpermeability Circulation Research. Feb, 2008 | Pubmed ID: 18048770 Neutrophil Caveolin-1 Expression Contributes to Mechanism of Lung Inflammation and Injury American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2008 | Pubmed ID: 17993589 Dual Regulation of Endothelial Junctional Permeability Science's STKE : Signal Transduction Knowledge Environment. Nov, 2007 | Pubmed ID: 18000237 Molecular Determinants of Endothelial Transcytosis and Their Role in Endothelial Permeability American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2007 | Pubmed ID: 17644753 GDI-1 Phosphorylation Switch at Serine 96 Induces RhoA Activation and Increased Endothelial Permeability Molecular and Cellular Biology. Sep, 2007 | Pubmed ID: 17636025 E3 Ubiquitin Ligase Cblb Regulates the Acute Inflammatory Response Underlying Lung Injury Nature Medicine. Aug, 2007 | Pubmed ID: 17618294 Interrelations/cross Talk Between Transcellular Transport Function and Paracellular Tight Junctional Properties in Lung Epithelial and Endothelial Barriers American Journal of Physiology. Lung Cellular and Molecular Physiology. Sep, 2007 | Pubmed ID: 17601795 Regulation of Cyclooxygenase-2 Expression by Small GTPase Rac2 in Bone Marrow Macrophages American Journal of Physiology. Lung Cellular and Molecular Physiology. Sep, 2007 | Pubmed ID: 17575012 Cdc42 Regulates the Restoration of Endothelial Adherens Junctions and Permeability Trends in Cardiovascular Medicine. Jul, 2007 | Pubmed ID: 17574122 RhoGDI-1 Modulation of the Activity of Monomeric RhoGTPase RhoA Regulates Endothelial Barrier Function in Mouse Lungs Circulation Research. Jul, 2007 | Pubmed ID: 17525371 Intersectin-1s Regulates the Mitochondrial Apoptotic Pathway in Endothelial Cells The Journal of Biological Chemistry. Jun, 2007 | Pubmed ID: 17405881 Protease-activated Receptor-3 (PAR3) Regulates PAR1 Signaling by Receptor Dimerization Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007 | Pubmed ID: 17376866 Myocardium Defects and Ventricular Hypoplasia in Mice Homozygous Null for the Forkhead Box M1 Transcription Factor Developmental Dynamics : an Official Publication of the American Association of Anatomists. Apr, 2007 | Pubmed ID: 17366632 Galphaq-TRPC6-mediated Ca2+ Entry Induces RhoA Activation and Resultant Endothelial Cell Shape Change in Response to Thrombin The Journal of Biological Chemistry. Mar, 2007 | Pubmed ID: 17197445 Blockade of Class IA Phosphoinositide 3-kinase in Neutrophils Prevents NADPH Oxidase Activation- and Adhesion-dependent Inflammation The Journal of Biological Chemistry. Mar, 2007 | Pubmed ID: 17197441 P38 MAPK Activation Coupled to Endocytosis is a Determinant of Endothelial Monolayer Integrity American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2007 | Pubmed ID: 16891390 Ca2+ Signaling, TRP Channels, and Endothelial Permeability Microcirculation (New York, N.Y. : 1994). Dec, 2006 | Pubmed ID: 17085428 Caveolin-1 Regulates NF-kappaB Activation and Lung Inflammatory Response to Sepsis Induced by Lipopolysaccharide Journal of Immunology (Baltimore, Md. : 1950). Oct, 2006 | Pubmed ID: 16982927 Novel Mechanism of Endothelial Nitric Oxide Synthase Activation Mediated by Caveolae Internalization in Endothelial Cells Circulation Research. Oct, 2006 | Pubmed ID: 16973909 Endothelial Cell-restricted Disruption of FoxM1 Impairs Endothelial Repair Following LPS-induced Vascular Injury The Journal of Clinical Investigation. Sep, 2006 | Pubmed ID: 16955137 Caveolin-1 Regulates Store-operated Ca2+ Influx by Binding of Its Scaffolding Domain to Transient Receptor Potential Channel-1 in Endothelial Cells Molecular Pharmacology. Oct, 2006 | Pubmed ID: 16822931 Regulation of Lung Neutrophil Recruitment by VE-cadherin American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2006 | Pubmed ID: 16782751 De Novo ICAM-1 Synthesis in the Mouse Lung: Model of Assessment of Protein Expression in Lungs American Journal of Physiology. Lung Cellular and Molecular Physiology. Sep, 2006 | Pubmed ID: 16714332 Ca2+ Influx Induced by Protease-activated Receptor-1 Activates a Feed-forward Mechanism of TRPC1 Expression Via Nuclear Factor-kappaB Activation in Endothelial Cells The Journal of Biological Chemistry. Jul, 2006 | Pubmed ID: 16709572 NF-kappa B Activation As a Pathological Mechanism of Septic Shock and Inflammation American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2006 | Pubmed ID: 16531564 Phosphatidylinositol 3-kinase Gamma Signaling Through Protein Kinase Czeta Induces NADPH Oxidase-mediated Oxidant Generation and NF-kappaB Activation in Endothelial Cells The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16527821 Signaling Mechanisms Regulating Endothelial Permeability Physiological Reviews. Jan, 2006 | Pubmed ID: 16371600 Cdc42 Regulates Adherens Junction Stability and Endothelial Permeability by Inducing Alpha-catenin Interaction with the Vascular Endothelial Cadherin Complex Circulation Research. Jan, 2006 | Pubmed ID: 16322481 Suppression of RhoA Activity by Focal Adhesion Kinase-induced Activation of P190RhoGAP: Role in Regulation of Endothelial Permeability The Journal of Biological Chemistry. Jan, 2006 | Pubmed ID: 16308318 SiRNA-induced Caveolin-1 Knockdown in Mice Increases Lung Vascular Permeability Via the Junctional Pathway American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2006 | Pubmed ID: 16183667 Cellular and Molecular Biology for Intensivists: a Primer--endothelial Cells Critical Care Medicine. Dec, 2005 | Pubmed ID: 16340438 Role of Phosphatidylinositol 3-kinase-gamma in Mediating Lung Neutrophil Sequestration and Vascular Injury Induced by E. Coli Sepsis American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2005 | Pubmed ID: 16183669 Cholesterol-dependent Syntaxin-4 and SNAP-23 Clustering Regulates Caveolar Fusion with the Endothelial Plasma Membrane The Journal of Biological Chemistry. Nov, 2005 | Pubmed ID: 16118213 Constitutive ENOS-derived Nitric Oxide is a Determinant of Endothelial Junctional Integrity American Journal of Physiology. Lung Cellular and Molecular Physiology. Sep, 2005 | Pubmed ID: 16093363 Functional Role of TRPC Channels in the Regulation of Endothelial Permeability Pflügers Archiv : European Journal of Physiology. Oct, 2005 | Pubmed ID: 15988589 G Alpha12 Interaction with AlphaSNAP Induces VE-cadherin Localization at Endothelial Junctions and Regulates Barrier Function The Journal of Biological Chemistry. Aug, 2005 | Pubmed ID: 15980433 Angiopoietin-1 Opposes VEGF-induced Increase in Endothelial Permeability by Inhibiting TRPC1-dependent Ca2 Influx Circulation Research. Jun, 2005 | Pubmed ID: 15920022 Inactivation of CD11b in a Mouse Transgenic Model Protects Against Sepsis-induced Lung PMN Infiltration and Vascular Injury Physiological Genomics. Apr, 2005 | Pubmed ID: 15831844 Lysophosphatidylcholine Modulates Neutrophil Oxidant Production Through Elevation of Cyclic AMP Journal of Immunology (Baltimore, Md. : 1950). Mar, 2005 | Pubmed ID: 15728511 Sphingosine 1-phosphate-induced Mobilization of Intracellular Ca2+ Mediates Rac Activation and Adherens Junction Assembly in Endothelial Cells The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15728185 Protease-activated Receptor-1 Activation of Endothelial Cells Induces Protein Kinase Calpha-dependent Phosphorylation of Syntaxin 4 and Munc18c: Role in Signaling P-selectin Expression The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15576373 LPS Activation of Toll-like Receptor 4 Signals CD11b/CD18 Expression in Neutrophils American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2005 | Pubmed ID: 15563689 RhoA/Rho-associated Kinase Pathway Selectively Regulates Thrombin-induced Intercellular Adhesion Molecule-1 Expression in Endothelial Cells Via Activation of I Kappa B Kinase Beta and Phosphorylation of RelA/p65 Journal of Immunology (Baltimore, Md. : 1950). Dec, 2004 | Pubmed ID: 15557193 SHIP2 is Recruited to the Cell Membrane Upon Macrophage Colony-stimulating Factor (M-CSF) Stimulation and Regulates M-CSF-induced Signaling Journal of Immunology (Baltimore, Md. : 1950). Dec, 2004 | Pubmed ID: 15557176 Integrated Control of Lung Fluid Balance American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2004 | Pubmed ID: 15531757 RNA Interference Targeting Transforming Growth Factor-beta Type II Receptor Suppresses Ocular Inflammation and Fibrosis Molecular Vision. Oct, 2004 | Pubmed ID: 15475878 Functional and Morphological Studies of Protein Transcytosis in Continuous Endothelia American Journal of Physiology. Lung Cellular and Molecular Physiology. Nov, 2004 | Pubmed ID: 15475492 Tumor Necrosis Factor-alpha-induced TRPC1 Expression Amplifies Store-operated Ca2+ Influx and Endothelial Permeability American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2004 | Pubmed ID: 15347566 Gbetagamma Activation of Src Induces Caveolae-mediated Endocytosis in Endothelial Cells The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15345719 CAMP Targeting of P38 MAP Kinase Inhibits Thrombin-induced NF-kappaB Activation and ICAM-1 Expression in Endothelial Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Nov, 2004 | Pubmed ID: 15246972 Albumin Mediates the Transcytosis of Myeloperoxidase by Means of Caveolae in Endothelial Cells Proceedings of the National Academy of Sciences of the United States of America. May, 2004 | Pubmed ID: 15136724 Protein Kinase Calpha Phosphorylates the TRPC1 Channel and Regulates Store-operated Ca2+ Entry in Endothelial Cells The Journal of Biological Chemistry. May, 2004 | Pubmed ID: 15016832 Role of Src-induced Dynamin-2 Phosphorylation in Caveolae-mediated Endocytosis in Endothelial Cells The Journal of Biological Chemistry. May, 2004 | Pubmed ID: 15007081 Albumin Endocytosis in Endothelial Cells Induces TGF-beta Receptor II Signaling American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2004 | Pubmed ID: 14729511 Cdc42 Regulates the Restoration of Endothelial Barrier Function Circulation Research. Feb, 2004 | Pubmed ID: 14656933 Oxidant Signaling in Lung Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2004 | Pubmed ID: 14656698 Caveolin Regulation of Endothelial Function American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2003 | Pubmed ID: 14604847 TLR4 Signaling Induces TLR2 Expression in Endothelial Cells Via Neutrophil NADPH Oxidase The Journal of Clinical Investigation. Oct, 2003 | Pubmed ID: 14561708 Intersectin Regulates Fission and Internalization of Caveolae in Endothelial Cells Molecular Biology of the Cell. Dec, 2003 | Pubmed ID: 12960435 Tumor Necrosis Factor-alpha Induces Nuclear Factor-kappaB-dependent TRPC1 Expression in Endothelial Cells The Journal of Biological Chemistry. Sep, 2003 | Pubmed ID: 12855710 E. Coli Pneumonia Induces CD18-independent Airway Neutrophil Migration in the Absence of Increased Lung Vascular Permeability American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2003 | Pubmed ID: 12818890 Two Waves of Platelet Secretion Induced by Thromboxane A2 Receptor and a Critical Role for Phosphoinositide 3-kinases The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12796499 RhoA Interaction with Inositol 1,4,5-trisphosphate Receptor and Transient Receptor Potential Channel-1 Regulates Ca2+ Entry. Role in Signaling Increased Endothelial Permeability The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12766172 Protein Kinase Calpha-induced P115RhoGEF Phosphorylation Signals Endothelial Cytoskeletal Rearrangement The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12754211 Protein Kinase C Modifications of VE-cadherin, P120, and Beta-catenin Contribute to Endothelial Barrier Dysregulation Induced by Thrombin American Journal of Physiology. Lung Cellular and Molecular Physiology. Aug, 2003 | Pubmed ID: 12740216 Tumor Necrosis Factor-alpha Induces Early-onset Endothelial Adhesivity by Protein Kinase Czeta-dependent Activation of Intercellular Adhesion Molecule-1 Circulation Research. May, 2003 | Pubmed ID: 12714560 VE-cadherin-induced Cdc42 Signaling Regulates Formation of Membrane Protrusions in Endothelial Cells The Journal of Biological Chemistry. May, 2003 | Pubmed ID: 12595527 Toll-like Receptor-4 (TLR4) Signaling Augments Chemokine-induced Neutrophil Migration by Modulating Cell Surface Expression of Chemokine Receptors Nature Medicine. Mar, 2003 | Pubmed ID: 12592402 Protein Transport Across the Lung Epithelial Barrier American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2003 | Pubmed ID: 12533309 Quantitative Analysis of Albumin Uptake and Transport in the Rat Microvessel Endothelial Monolayer American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2003 | Pubmed ID: 12471015 Role of Ca2+ Signaling in the Regulation of Endothelial Permeability Vascular Pharmacology. Nov, 2002 | Pubmed ID: 12747958 Transport of Nitrated Albumin Across Continuous Vascular Endothelium Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12370442 Galpha(q) and Gbetagamma Regulate PAR-1 Signaling of Thrombin-induced NF-kappaB Activation and ICAM-1 Transcription in Endothelial Cells Circulation Research. Sep, 2002 | Pubmed ID: 12215488 Nitric Oxide Stimulates Macrophage Inflammatory Protein-2 Expression in Sepsis Journal of Immunology (Baltimore, Md. : 1950). Aug, 2002 | Pubmed ID: 12165537 Impairment of Store-operated Ca2+ Entry in TRPC4(-/-) Mice Interferes with Increase in Lung Microvascular Permeability Circulation Research. Jul, 2002 | Pubmed ID: 12114324 Thrombin Receptors Activate G(o) Proteins in Endothelial Cells to Regulate Intracellular Calcium and Cell Shape Changes The Journal of Biological Chemistry. Sep, 2002 | Pubmed ID: 12039967 PKCzeta Regulates TNF-alpha-induced Activation of NADPH Oxidase in Endothelial Cells Circulation Research. May, 2002 | Pubmed ID: 12016268 Role of NADPH Oxidase in the Mechanism of Lung Neutrophil Sequestration and Microvessel Injury Induced by Gram-negative Sepsis: Studies in P47phox-/- and Gp91phox-/- Mice Journal of Immunology (Baltimore, Md. : 1950). Apr, 2002 | Pubmed ID: 11937554 Vesicle Formation and Trafficking in Endothelial Cells and Regulation of Endothelial Barrier Function Histochemistry and Cell Biology. Feb, 2002 | Pubmed ID: 11935286 Modulatory Role of Focal Adhesion Kinase in Regulating Human Pulmonary Arterial Endothelial Barrier Function The Journal of Physiology. Mar, 2002 | Pubmed ID: 11897849 Time-dependent Reversal of Sepsis-induced PMN Uptake and Lung Vascular Injury by Expression of CD18 Antagonist American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2002 | Pubmed ID: 11880306 Protein Kinase C-delta (PKC-delta ) is Activated by Type I Interferons and Mediates Phosphorylation of Stat1 on Serine 727 The Journal of Biological Chemistry. Apr, 2002 | Pubmed ID: 11839738 Albumin Transcytosis in Mesothelium: Further Evidence of a Transcellular Pathway in Polarized Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2002 | Pubmed ID: 11741809 Role of Neutrophil NADPH Oxidase in the Mechanism of Tumor Necrosis Factor-alpha -induced NF-kappa B Activation and Intercellular Adhesion Molecule-1 Expression in Endothelial Cells The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11729200 Pseudomonas aeruginosa Kaynaklı Akciğer Hasarı Modeli Varsha Suresh Kumar1, Ruxana T. Sadikot2, Jeanette E. Purcell3, Asrar B. Malik1, Yuru Liu1 1Department of Pharmacology, University of Illinois College of Medicine, University of Illinois at Chicago, 2Section of Pulmonary and Critical Care Medicine, Atlanta VAMC, Emory University, 3Biologic Resources Lab, University of Illinois at Chicago Immunology and Infection
Pseudomonas aeruginosa Kaynaklı Akciğer Hasarı Modeli Varsha Suresh Kumar1, Ruxana T. Sadikot2, Jeanette E. Purcell3, Asrar B. Malik1, Yuru Liu1 1Department of Pharmacology, University of Illinois College of Medicine, University of Illinois at Chicago, 2Section of Pulmonary and Critical Care Medicine, Atlanta VAMC, Emory University, 3Biologic Resources Lab, University of Illinois at Chicago Immunology and Infection